“…16 Moreover, they are objective measurements less prone to errors than the subjective and difficult assessment of the morphology of the aortic arch, either in 2D or with 3D-4D, the evaluation of the isthmus-ductal angle, or the Doppler analysis of flow disturbances, which have been also proposed as predictive parameters. 1,16,17,24,25 The cardiac parameters selected after multivariate adjustment differed between both diagnosis groups: in the early group, cardiac parameters directly related to aortic dimensions were the best predictors; whereas in the late group, the most predictive markers were indirect signs. In this sense, it is noteworthy that although true CoAo displayed similar echocardiographic features throughout pregnancy and it was not different regarding the GA at diagnosis (≤28 and >28 weeks), normal fetuses with late onset cardiac asymmetry had significantly smaller z-scores of the aortic isthmus than false positive cases of the early group.…”