Use of 3D bioprinting in biomedical engineering for clinical application

Karzyński, Kamil; Kosowska, Katarzyna; Ambrożkiewicz, Filip; Berman, Andrzej; Cichoń, Justyna; Klak, Marta; Serwańska-Świętek, Marta; Wszoła, Michał

doi:10.5114/ms.2018.74827

Cited by 24 publications

(11 citation statements)

References 14 publications

(16 reference statements)

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“…The earliest form of bioprinting originated as a modification of commercially available inkjet printers, by Charles Hull in 1984. 63 This was done by the addition of a movable vertical axis platform and using bioinks in the ink cartridges. Bioink droplets were deposited onto the print platform through the ink cartridges, actuated by either piezoelectric or thermal forces.…”

Section: Inkjet Bioprintingmentioning

confidence: 99%

Silk Fibroin as a Bioink – A Thematic Review of Functionalization Strategies for Bioprinting Applications

Tan

Liu

Mitryashkin

et al. 2022

ACS Biomater. Sci. Eng.

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Bioprinting is an emerging tissue engineering technique that has attracted the attention of researchers around the world, for its ability to create tissue constructs that recapitulate physiological function. While the technique has been receiving hype, there are still limitations to the use of bioprinting in practical applications, much of which is due to inappropriate bioink design that is unable to recapitulate complex tissue architecture. Silk fibroin (SF) is an exciting and promising bioink candidate that has been increasingly popular in bioprinting applications because of its processability, biodegradability, and biocompatibility properties. However, due to its lack of optimum gelation properties, functionalization strategies need to be employed so that SF can be effectively used in bioprinting applications. These functionalization strategies are processing methods which allow SF to be compatible with specific bioprinting techniques. Previous literature reviews of SF as a bioink mainly focus on discussing different methods to functionalize SF as a bioink, while a comprehensive review on categorizing SF functional methods according to their potential applications is missing. This paper seeks to discuss and compartmentalize the different strategies used to functionalize SF for bioprinting and categorize the strategies for each bioprinting method (namely, inkjet, extrusion, and light-based bioprinting). By compartmentalizing the various strategies for each printing method, the paper illustrates how each strategy is better suited for a target tissue application. The paper will also discuss applications of SF bioinks in regenerating various tissue types and the challenges and future trends that SF can take in its role as a bioink material.

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Section: Inkjet Bioprintingmentioning

confidence: 99%

Silk Fibroin as a Bioink – A Thematic Review of Functionalization Strategies for Bioprinting Applications

Tan

Liu

Mitryashkin

et al. 2022

ACS Biomater. Sci. Eng.

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“…However, the transplantations are plagued with problems. Diabetic patients have to undergo surgery, which is only possible if organs are readily available, and thereafter, the individual will be on chronic immunosuppression, which is not ideal as T1D often manifests in children [77]. Thus, the introduction of 3D printing in the biological field opened the doors to the regeneration and replacement of biological tissue and organs (bioimplants) for the development of the artificial pancreas [78].…”

Section: The Use Of 3d Bio-printing To Engineer An Artificial Pancreas and Other 21st Century Techniquesmentioning

confidence: 99%

“…Three-dimensional (3D) printing may take place via inkjet, laser printing, stereolithography, or via extrusion [77]. The extrusion method of 3D printing was carried out by Duin et al to formulate a methylcellulose/alginate hydrogel loaded with pancreatic islets.…”

Section: The Use Of 3d Bio-printing To Engineer An Artificial Pancreas and Other 21st Century Techniquesmentioning

confidence: 99%

Advanced Hydrogels for the Controlled Delivery of Insulin

2021

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Insulin is a peptide hormone that is key to regulating physiological glucose levels. Its molecular size and susceptibility to conformational change under physiological pH make it challenging to orally administer insulin in diabetes. The most effective route for insulin delivery remains daily injection. Unfortunately, this results in poor patient compliance and increasing the risk of micro- and macro-vascular complications and thus rising morbidity and mortality rates in diabetics. The use of 3D hydrogels has been used with much interest for various biomedical applications. Hydrogels can mimic the extracellular matrix (ECM) and retain large quantities of water with tunable properties, which renders them suitable for administering a wide range of sensitive therapeutics. Several studies have demonstrated the fixation of insulin within the structural mesh of hydrogels as a bio-scaffold for the controlled delivery of insulin. This review provides a concise incursion into recent developments for the safe and effective controlled delivery of insulin using advanced hydrogel platforms with a special focus on sustained release injectable formulations. Various hydrogel platforms in terms of their methods of synthesis, properties, and unique features such as stimuli responsiveness for the treatment of Type 1 diabetes mellitus are critically appraised. Key criteria for classifying hydrogels are also outlined together with future trends in the field.

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“…Later, during the first decade of the 21st century, the first 3D printed human organ was transplanted [13]; novel inkjet modified printers for proteins and living cells were introduced [14] and first patented; cell spherical aggregates were developed as an alternative for bioink [15]; and the first commercial bioprinter was invented. These are some of the milestones [16], [17] leading to the field of bioprinting to hold onto its promise to revolutionize health care. While there are excellent reviews of the different bioprinting techniques available, we summarize below the most relevant technologies to create structures of interest for safety analysis of therapeutic products and disease progression.…”

Section: Introductionmentioning

confidence: 99%

Bioprinting: A Strategy to Build Informative Models of Exposure and Disease

Caceres-Alban

Sanchez

Casado

2023

IEEE Rev. Biomed. Eng.

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Novel additive manufacturing techniques are revolutionizing fields of industry providing more dimensions to control and the versatility of fabricating multi-material products. Medical applications hold great promise to manufacture constructs of mixed biologically compatible materials together with functional cells and tissues. We reviewed technologies and promising developments nurturing innovation of physiologically relevant models to study safety of chemicals that are hard to reproduce in current models, or diseases for which there are no models available. Extrusion-, inkjet-and laser-assisted bioprinting are the most used techniques. Hydrogels as constituents of bioinks and biomaterial inks are the most versatile materials to recreate physiological and pathophysiological microenvironments. The highlighted bioprinted models were chosen because they guarantee post-printing cellular viability while maintaining desirable mechanical properties of their constitutive bioinks or biomaterial inks to ensure their printability. Bioprinting is being readily adopted to overcome ethical concerns of in vivo models and improve the automation, reproducibility, geometry stability of traditional in vitro models. The challenges for advancing the technological level readiness of bioprinting require overcoming heterogeneity, microstructural complexity, dynamism and integration with other models, to generate multi-organ platforms that can inform about biological responses to chemical exposure, disease development and efficacy of novel therapies.

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Use of 3D bioprinting in biomedical engineering for clinical application

Cited by 24 publications

References 14 publications

Silk Fibroin as a Bioink – A Thematic Review of Functionalization Strategies for Bioprinting Applications

Silk Fibroin as a Bioink – A Thematic Review of Functionalization Strategies for Bioprinting Applications

Advanced Hydrogels for the Controlled Delivery of Insulin

Bioprinting: A Strategy to Build Informative Models of Exposure and Disease

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