Use fresh‐frozen plasma in newborns, older infants and adolescents on the outcome of bleeding

Veljković, Dobrila

doi:10.1111/j.1751-2824.2011.01482.x

Cited by 4 publications

(3 citation statements)

References 69 publications

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“…Infusions of FFP in neonates is effective in reducing blood loss associated with extracorporeal membrane oxygenation (ECMO) or cardio-pulmonary bypass and to treat active bleeding due to DIC, liver failure or Vitamin K deficiency [6]. However, routine use of FFP in sick preterm neonates for volume expansion, to treat coagulopathy in the absence of bleeding, or for partial exchange transfusion does not decrease morbidity or mortality [7].…”

Section: Introductionmentioning

confidence: 99%

Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

Dogra

Kaur

Basu

et al. 2019

Indian J Hematol Blood Transfus

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Blood transfusion is an indispensable part of modern medical and surgical practices. More than 35% of critically ill patients receive transfusion of blood components during their intensive care unit stay. The aim of study is to obtain an information regarding the relationship of platelet concentrate (PC) and fresh frozen plasma (FFP) transfusion on clinical outcome of neonates admitted in neonatal ICU (NICU). This prospective cohort study was conducted from 1st November 2011 to 30th April 2013. The clinical history, blood component details and laboratory parameters were evaluated with clinical outcome. The neonates requiring PC and FFP transfusion were followed up in blood bank for laboratory parameters. Clinical parameters were noted from case file. During the study period, 291 neonates were admitted in NICU. 2 neonates had congenital malformations and thus, were excluded from the study. Of the remaining 289 neonates, 49 neonates received transfusion of platelets and/or FFP. The combined mean donor exposure for all components was found to be 1.48. The mean volume of PC and FFP transfused was 20 ml and 30 ml respectively. The mean pre-and posttransfusion platelet count was 34,000 ll and 42,000 ll respectively. The mean pre-and post-transfusion INR was 2.37 and 1.53 respectively. There was a significant increase in platelet count and decrease in INR in transfused neonates. However, no clinical benefit of PC and FFP transfusion seen on bleeding. Transfusion of PC and FFP has significant effect on laboratory parameters as compared to clinical parameter.

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Section: Introductionmentioning

confidence: 99%

Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

Dogra

Kaur

Basu

et al. 2019

Indian J Hematol Blood Transfus

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show abstract

“…As opposed to erythrocyte and platelet transfusions, current recommendations for FFP transfusions are based on limited data [4]. Despite the paucity of evidence for efficacy, FFP transfusions remain popular among clinicians; Veljkovic et al [13] reported that 60% recipients of FFP at the Institute for Mother and Child Health Care of Serbia were <1 year old. The GSH neonatal unit did not have a written standardized protocol to inform FFP transfusion decisions during the 5 year study period.…”

Section: Discussionmentioning

confidence: 99%

Fresh Frozen Plasma Use in a Neonatal Unit in South Africa

Raban

Harrison

2015

J Trop Pediatr

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“…It contains adequate levels of all soluble coagulation factors like >70% fibrinogen, albumin, natural anticoagulants (protein C, protein S, antithrombin, tissue factor pathway inhibitor) and added anticoagulants. 9 It is more available than individual clotting factor. FFP is used in neonates with abnormal clotting studies, with the assumption that correcting the clotting studies into the normal range will reduce the risk of, or stop ongoing bleeding.…”

Section: Introductionmentioning

confidence: 99%

Role of prophylactic fresh frozen plasma in critically ill neonate to prevent bleeding in disseminated intravascular coagulation: a randomized controlled trial

Kamal

Mamun

Hossain

2023

Bangladesh Med Res Counc Bull

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Background: Disseminated intravascular coagulation (DIC) has a high prevalence in critically ill neonates. In suspicion of DIC based on abnormal coagulation parameter is a common trigger to transfuse fresh frozen plasma (FFP), even in absence of bleeding. In past years, use of FFP has increased and has expanded to include prophylactic use in neonates especially in neonatal intensive care units (NICUs) as it contains several coagulation factors. Several studies suggest that, prophylactic use of FFP has no role to prevent bleeding in disseminated intravascular coagulation (DIC), but carries increase risk of transfusion related mortality and morbidity. Objective: To assess the effectiveness of prophylactic use of FFP in critically ill neonate to prevent bleeding in DIC. Methods: This randomized, open-label, blinded end-point study was conducted in Bangladesh Institute of Child Health and Dhaka Shishu (Children) Hospital from July, 2019 to June, 2021. Term, critically ill neonates who had underlying disease, suspected to develop DIC were conveniently selected. Later, they were randomly allocated using software in intervention group, who received 10 ml/kg of FFP along with standard management and control group, who received only standard management. Coagulation parameters were checked before and 24 hour after intervention in both groups. Outcome was occurrence of bleeding as a indicator of DIC. Results: The mean age was 8.55 ± 3.5 days in intervention and 8.92 ± 6.1 days in control group. Male patients were predominant. There was no significant difference in baseline characteristics between two groups. The difference of mean ± SD of coagulation parameters between two groups were nonsignificant before intervention. Even after FFP transfusion, DIC developed among 40.1% neonates in intervention and without FFP transfusion among 48.9% neonates in control group without any significant difference (P-value >0.05). Conclusion: Study result found no role of prophylactic use of FFP in critically ill neonate to prevent bleeding in DIC. Bangladesh Medical Res Counc Bull 2022; 48: 146-153

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Use fresh‐frozen plasma in newborns, older infants and adolescents on the outcome of bleeding

Cited by 4 publications

References 69 publications

Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

Fresh Frozen Plasma Use in a Neonatal Unit in South Africa

Role of prophylactic fresh frozen plasma in critically ill neonate to prevent bleeding in disseminated intravascular coagulation: a randomized controlled trial

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