Use and Results of Antidepressant Treatment: Patients' Perception

Martín-Vázquez, María-José; Garcı́a-Toro, Mauro; Campoamor, Francisco; Pareja, Antonio; Aguirre, Iratxe; Salvà, Joan; Roca, Miquel

doi:10.2174/157488511798109619

Cited by 5 publications

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“…In the current study the frequency of treatment non adherence among patients with depressive disorder was 26% (95% CI; 21.9%-30.6%). This finding is consistent with previous studies done in Spain (30.1% [ 22 ]), in United Kingdom (30% [ 16 ]) and in USA (28% [ 34 ]).…”

Section: Discussionsupporting

confidence: 94%

“…Patients who had medication side effects were 2.46 times more likely to be non-adherent than those who don’t have medication side effects. This association is supported by a study done in Malaysia [ 18 ] and other systematic reviews in Spanish and English languages [ 22 ]. The association might be related to intolerance of the medication adverse effects, thinking that the side effects of the medications are harmful; in addition a prescriber’s inadequate knowledge and skill in managing the illness and related adverse effect can have an impact and cause patients to prematurely stop medications [ 38 ].…”

Section: Discussionsupporting

confidence: 54%

“…Different studies show factors like duration of illness, severity of illness, previous history of admission, comorbid physical illness, lack of social support, presence of self-stigma, and substance use are correlates of treatment non-adherence among patients with depressive disorders [ 18 – 22 ]. In addition, those patients who have poor quality of life tend to be less adherent to their treatments [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Magnitude and factors associated with treatment non-adherence among patients with depressive disorders at St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019: A cross sectional study

2022

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Background Inadequate adherence to treatment is among the main underlying causes of depression becoming a chronic problem. In developing countries due to limited access to health care, inaccurate diagnoses, and scarcity of medications, poor adherence may become an even larger obstacle in the treatment of depression. The current study aims to assess the magnitude and factors related to treatment non-adherence among patients with depressive disorders. Objective To assess the magnitude and factors associated with treatment non adherence among patients with depressive disorders at St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019. Methods A hospital-based cross-sectional study was conducted among 415 respondents using systematic random sampling technique. Medication adherence was assessed by using Medication Adherence Rating Scale. Data was entered to Epi-data version 3.1 and analyzed using SPSS version 20. Binary logistic analysis was done and P-values less than 0.05 were considered statistically significant. Results The prevalence of treatment non-adherence among patients with depressive disorders was 26% (95%CI; 21.2, 32.5). Previous suicide attempt (AOR = 3.05, 95%CI; 1.82, 5.12), medication side effects (AOR = 2.46, 95%CI; 1.47, 4.11), moderate to high self-stigma (AOR = 2.60, 95%CI; 1.45, 4.66), and poor quality of life (AOR = 2.47, 95%CI; 1.42, 4.28) were significantly associated with treatment non-adherence among patients with depressive disorders. Conclusion and recommendation Treatment non-adherence is a common problem among patients being treated for depressive disorders. Previous suicide attempts, medication side effects, moderate to high self-stigma, and poor quality of life were significantly associated with treatment non-adherence. Appropriate interventions should be developed to promote measures to facilitate adherence in this group of patients, and address the associated factors when applicable.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Magnitude and factors associated with treatment non-adherence among patients with depressive disorders at St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019: A cross sectional study

2022

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“…This might be due to illiterate patients being afraid of the drug side effects owing to their limited knowledge about diseases and drugs, in addition to their unwillingness to discuss the same with medical professionals. Similar findings regarding poor compliance among less-educated patients were reported in a study from Spain [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Self-Reported Antidepressant Drug Side Effects, Medication Adherence, and Its Associated Factors among Patients Diagnosed with Depression at the Psychiatric Hospital of Nepal

Marasine

Sankhi

Lamichhane

et al. 2020

Depression Research and Treatment

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Objective. The present study is aimed at evaluating the side effects of antidepressant drugs, medication adherence (MA), and associated factors among patients diagnosed with depression at a psychiatric hospital in western Nepal. Methods. A prospective cross-sectional study was conducted among 174 patients visiting the outpatient clinic of a psychiatric hospital. The antidepressant side effect checklist (ASEC) was used to classify the reported antidepressant drug side effects into mild, moderate, and severe types. The Naranjo adverse drug reaction (ADR) probability scale was employed to assess the ADRs, and the Morisky Green Levine Adherence (MGLA) score was employed to determine the rate of medication adherence. Descriptive statistics and bivariate analysis were used, and a P value < 0.05 was taken as statistically significant in the multivariate analysis. Results. The patients were mostly female (55.74%), with a median (IQR) age of 32 (20) years. Approximately 74.13% of the patients experienced antidepressant side effects, where insomnia (17.05%) and anxiety (17.05%) were the most common. More than half of the patients (52.29%) had a low level of adherence. Females were 1.01 times more likely to be nonadherent to their antidepressant medications compared to males, adjusted odds ratio (AOR): 1.001 (0.31-1.63). Similarly, illiterate patients tended to be more nonadherent compared to literates, AOR: 1.342 (0. 93-2.82), and unemployed individuals were 1.5 times more likely to be nonadherent to their medications compared to employed individuals, AOR: 1.46 (1.16-4.13). Likewise, patients with severe side effects were more prone to develop nonadherence than those with moderate side effects, AOR: 1.173 (0.42-3.25). A significant association was found between the Naranjo score and medication adherence. Conclusions. This study suggests that antidepressant drug side effects were more prevalent and medication adherence was extremely poor among depressive patients in psychiatric hospitals. Factors such as gender, occupation, education, side effects, and ADRs attributed to poor medication adherence in patients.

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“…9 Several predictors of non-adherence have been reported including patient concerns about treatment-related side effects, medication dependence, and patients' beliefs, clinical factors (lack of patients education and follow-up), and social factors (isolation, poverty, lack of social support, low income, and educational level). [10][11][12][13][14] In addition to these, Pompili et al have reported younger age (<40 years), comorbidity with substance use and personality disorders, severity of illness, and poor therapeutic alliance between the patient and physician as indicators of non-adherence. 15 Given the high social, clinical, and economic impact of non-adherence among patients who are affected by mood disorders it is imperative to identify key predictors in order to recognize patients at risk for non-adherence.…”

Section: Introductionmentioning

confidence: 99%

<p>Assessment of current clinical practices for major depression in Japan using a web-based questionnaire</p>

Hori¹,

Yamato²

2019

NDT

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PurposeTo investigate the current clinical practice of Japanese physicians in the diagnosis and management of major depression (major depressive disorder [MDD]).Patients and methodsJapanese physicians specializing in psychiatry or psychosomatic medicine in the medical database of Nihon Ultmarc Inc. (Chuo-Ku, Tokyo, Japan), who had treated ≥30 patients with MDD in the past month were invited to complete a web-based questionnaire from January 15 to 29, 2018. The questionnaire was comprised of 28 questions pertaining to the physician’s background, the criteria and tools used to diagnose MDD during physician–patient consultation, and actual and preferred duration of physician–patient consultation. Responses were given as single answer numerical values or as multiple-choice answers.ResultsFrom the 518 physicians invited to participate, 340 completed questionnaires were analyzed. Respondents were predominantly male (90%), hospital based (73%), affiliated with the Department of Psychiatry (95%), and members of the Japanese Society of Psychiatry and Neurology (87%). The majority of physicians (84%) agreed that “improvement of cognitive dysfunction caused by major depression is an important factor for patients to return to work” was the most challenging aspect of MDD diagnosis and management. Moreover, 83% of physicians conducted psychological assessments using a cognition evaluation test with most of their patients at the time of MDD diagnosis; the most commonly used tool was the Hasegawa Dementia Scale-Revised. Both hospital-based physicians and general practitioners would prefer to have longer consultations with their patients.ConclusionPhysicians acknowledge the importance of the assessment and management of cognitive dysfunction in patients with MDD. However, most physicians would prefer to have longer consultation times with their patients for the diagnosis of MDD. In the future, it may be useful to introduce digital tools (eg, THINC-it®) for the initial screening of cognitive dysfunction.

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Use and Results of Antidepressant Treatment: Patients' Perception

Cited by 5 publications

References 0 publications

Magnitude and factors associated with treatment non-adherence among patients with depressive disorders at St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019: A cross sectional study

Magnitude and factors associated with treatment non-adherence among patients with depressive disorders at St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019: A cross sectional study

Self-Reported Antidepressant Drug Side Effects, Medication Adherence, and Its Associated Factors among Patients Diagnosed with Depression at the Psychiatric Hospital of Nepal

<p>Assessment of current clinical practices for major depression in Japan using a web-based questionnaire</p>

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