Use and characteristics of a novel lipid particle-forming matrix as a drug-carrier system

Bohlinder, Karin; Olsson, B-M; Ragnarsson, Gert; Singh, Satish K.; Öhman, G. Stjernström; Wadsten, T.; Carlsson, Anders; Herslöf, Bengt G.

doi:10.1016/0928-0987(94)90010-8

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…The major types of lipids that are present in the human body which plays major roles in metabolic processes are: triacylglycerols, free fatty acids, phospholipids, sphingolipids, bile salts, steroids and sterols, cholesterol, eicosanoids, and fat-soluble vitamins. Lipid modification strategies for the production of functional fats and oils include chemically or lipase-catalyzed interesterification or acidolysis reactions and genetic engineering of oilseed crops [16][17][18][19].…”

Section: Lipidsmentioning

confidence: 99%

Some Multifunctional Lipid Excipients and Their Pharmaceutical Applications

Devi¹,

Agarwal²

2019

Int J Pharm Pharm Sci

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This review is generally focussed on lipid-based excipients in solid oral formulations which increase its bioavailability. Several approaches have been used to deliver the drug efficiently in the body, and lipid excipients are one of the promising drug delivery systems which address challenges like solubility and bioavailability of water-soluble drugs. Lipids excipients can be tailored to meet a wide range of product requirements like disease indication, route of administration, stability, toxicity, and efficacy. This review discusses novel lipids like Compritol 888 ATO, Dynasan 114, and Precirol ATO 5 and how these can be employed for devicing efficient drug delivery models and thereby have used in cosmetic and pharmaceutical industries.Lipids can be classified in many ways, due to their different composition, nature and origin. According to with Bloor's classification, lipids can be divided into simple lipids, compound lipids, and derived lipids. Individual characteristics are not discussed in this section because they are well known. Simple LipidsThese are those compounds which belong to heterogeneous class of predominantly nonpolar compounds such as Lecithin and Cephalins. Compound LipidsThese are esters of fatty acids with alcohols. Compounds molecules also contain additional functional groups such as a phosphate ion, simple sugar, amino acid, sulphate ion and oligopeptides. Examples are fatty acids, alcohols, monoglycerides and diglycerides, steroids, terpenes, carotenoids. Derived LipidsThese are those substances which are derived from simple and compound lipids by hydrolysis. Derived lipids include fatty acids, alcohols, monoglycerides and diglycerides, steroids, terpenes, carotenoids. Steroids, terpenes and carotenoids are the most common derived lipids. Some of the most important lipids are shown in table 1, [20][21][22][23][24][25].

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Section: Lipidsmentioning

confidence: 99%

Some Multifunctional Lipid Excipients and Their Pharmaceutical Applications

Devi¹,

Agarwal²

2019

Int J Pharm Pharm Sci

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“…1 New drug delivery systems based upon lipids have been reported. [2][3][4] All lipid based systems containing unsaturated lipids are susceptible to degradation by oxidation. Lipid oxidation is the primary route of degradation for these systems and is a major factor in the deterioration of foods and fats, with pathological effects and a suspected contribution to atherosclerosis, cancer and ageing.…”

Section: Introductionmentioning

confidence: 99%

The spectrophotometric determination of hydroperoxide and peroxide in a lipid pharmaceutical product by flow injection analysis

Bloomfield¹

1999

Analyst

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A sensitive, rapid and automatable flow injection analysis procedure is described for the determination of total hydroperoxides and peroxides in lipid products. All unsaturated lipids are susceptible to degradation by oxidation, and the quantification of these major oxidation products is an essential measure of lipid product stability. In this methodology a lipid emulsion is dispersed and injected into an acidic solution of propan-2-ol, which is then merged with iodide ion in situ in a two-stream manifold. The lipid hydroperoxide oxidises acidified iodide to iodine, which is detected spectrophotometrically at 350 nm. The closed conditions prevent interference from atmospheric oxygen and the short reaction time minimises interference from side reactions. Conditions were optimised, using experimental design, for a lipid product under development at GlaxoWellcome. A two-level half-fractional factorial design was applied to screen for the critical factors, followed by a multi-level central composite design to optimise these variables. The resulting method was fully validated and is linear down to 0.1 nmol ml-1. This approach should be applicable to other lipid formulations and offers significant advantages in terms of speed, automation and precision compared with existing manual procedures.

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Lipids, Pharmaceutical and Cosmetic Use

Hernández¹

2012

Kirk-Othmer Encyclopedia of Chemical Technology

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Lipid nutritional supplements have been in use before the term nutraceutical was coined. Products such as fish oils, shark cartilege, shark liver oil, and vitamins have been in the market since the beginning of the twentieth century. Some of the health claims of these products lacked strict scientific documentation in the past, and their curative properties were mostly anecdotal. However there is a better understanding of the biological properties of lipids and their application has extended to pharmaceuticals and cosmetics fields, such as disease prevention and treatment, excipients and coadjuvants, trans‐dermal carriers and skin emolliency agents. This has led to the development of bioactive cosmetic and pharmaceutical products whose name is coined as cosmeceutical.

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Use and characteristics of a novel lipid particle-forming matrix as a drug-carrier system

Cited by 10 publications

References 14 publications

Some Multifunctional Lipid Excipients and Their Pharmaceutical Applications

Some Multifunctional Lipid Excipients and Their Pharmaceutical Applications

The spectrophotometric determination of hydroperoxide and peroxide in a lipid pharmaceutical product by flow injection analysis

Lipids, Pharmaceutical and Cosmetic Use

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