Usage of new bacterial adjuvants for vaccination by anti-influenza and anti-poliomyelitis vaccines

Рыбалко, С. Л.; Khristova, Marina L.; Shapiro, A. V.; Varbanets, L.D.; Zubkova, N. L.; Задорожна, В. І.; Ivans'ka, N. V.; Sorokulova, Iryna; Grytsak, T. F.; Furzikova, T. M.; Pinchuk, Ilya; Patskovski, Yu. V.; Diadiun, S. T.; Смирнов, В. В.; Urdaci, María C.

doi:10.7124/bc.00065a

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Studies indicate Bacillus subtilis 3 is not only effective for the prevention and treatment of influenza but also helpful in the prevention and treatment of bacterial infections in both animal models [77,78] and humans [78,79]. The antibacterial property of this strain is due to its ability to produce an antibiotic named aminocoumarin which can suppress a wide range of pathogens and also strengthen host resistance [80]. Furthermore, a double-blinded, placebo-controlled trial of the combination of different probiotic strains containing Lacticaseibacillus paracasei subsp.…”

Section: Influenzamentioning

confidence: 99%

Probiotic Effects on Disease Prevention and Treatment

Farahmandi¹,

Sulaimany²

2024

Advances in Probiotics for Health and Nutrition

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Research on the probiotic effect in preventing or treating diseases has attracted scientists’ attention for many decades. Findings of probiotics effects on human health indicate that they are not only no detrimental but also may have a beneficial effect on the host. Indeed, the effectiveness of probiotics depends on the type of utilized strain, duration, dose administration, and single or combined strains used that can be different in a specific disease. Therefore, probiotics can play a significant role in the treatment and prevention of different diseases through several mechanisms; for instance, stimulating respiratory immunity in the airway and enhancing resistance to respiratory tract infections, can prevent or reduce the duration of respiratory system diseases. By ameliorating glucose metabolism, reducing inflammation and oxidative stress in pancreatic cells, and preventing the destruction of β-pancreatic cells, may prevent the onset of diabetes and the pathogenesis of diabetic retinopathy as well. Moreover, using their metabolites, especially short-chain fatty acids production, probiotics may have an important effect on weight modifications. Finally, from the regulation of important neurotransmitters and regulation of inflammatory markers, it may be effective in mental disorders improvement.

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Section: Influenzamentioning

confidence: 99%

Probiotic Effects on Disease Prevention and Treatment

Farahmandi¹,

Sulaimany²

2024

Advances in Probiotics for Health and Nutrition

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“…the production of antibiotic aminocoumacin with a broad spectrum of pathogen suppression (18) and with the stimulation of immune resistance of the host (19). Previously, we found that some bacteria can produce peptides mimicking hemagglutinin of the influenza virus (20).…”

mentioning

confidence: 99%

Anti-influenza Activity of a Bacillus subtilis Probiotic Strain

Starosila

Рыбалко

Varbanetz

et al. 2017

Antimicrob Agents Chemother

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Among Bacillus bacteria, B. subtilis is the species that produces the most antimicrobial compounds. In this study, we analyzed the activity of probiotic strain B. subtilis 3 against the influenza virus. The antiviral effect of this strain has been demonstrated in vitro and in vivo. A new peptide, P18, produced by the probiotic strain was isolated, purified, chemically synthesized, and characterized. Cytotoxicity studies demonstrated no toxic effect of P18 on Madin-Darby canine kidney (MDCK) cells, even at the highest concentration tested (100 g/ml). Complete inhibition of the influenza virus in vitro was observed at concentrations of 12.5 to 100 g/ ml. The protective effect of P18 in mice was comparable to that of oseltamivir phosphate (Tamiflu). Further study will assess the potential of peptide P18 as an antiviral compound and as a promising candidate for the development of new antiviral vaccines.

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Usage of new bacterial adjuvants for vaccination by anti-influenza and anti-poliomyelitis vaccines

Cited by 2 publications

References 12 publications

Probiotic Effects on Disease Prevention and Treatment

Probiotic Effects on Disease Prevention and Treatment

Anti-influenza Activity of a Bacillus subtilis Probiotic Strain

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