Eye gaze interfaces are an emerging technology that allows users to control graphical user interfaces (GUIs) simply by looking at them. However, using gaze-controlled GUIs can be a demanding task, resulting in high cognitive and physical load and fatigue. To address these challenges, we propose the concept and model of an adaptive human-assistive human–computer interface (HA-HCI) based on biofeedback. This model enables effective and sustainable use of computer GUIs controlled by physiological signals such as gaze data. The proposed model allows for analytical human performance monitoring and evaluation during human–computer interaction processes based on the damped harmonic oscillator (DHO) model. To test the validity of this model, the authors acquired gaze-tracking data from 12 healthy volunteers playing a gaze-controlled computer game and analyzed it using odd–even statistical analysis. The experimental findings show that the proposed model effectively describes and explains gaze-tracking performance dynamics, including subject variability in performance of GUI control tasks, long-term fatigue, and training effects, as well as short-term recovery of user performance during gaze-tracking-based control tasks. We also analyze the existing HCI and human performance models and develop an extension to the existing physiological models that allows for the development of adaptive user-performance-aware interfaces. The proposed HA-HCI model describes the interaction between a human and a physiological computing system (PCS) from the user performance perspective, incorporating a performance evaluation procedure that interacts with the standard UI components of the PCS and describes how the system should react to loss of productivity (performance). We further demonstrate the applicability of the HA-HCI model by designing an eye-controlled game. We also develop an analytical user performance model based on damped harmonic oscillation that is suitable for describing variability in performance of a PC game based on gaze tracking. The model’s validity is tested using odd–even analysis, which demonstrates strong positive correlation. Individual characteristics of users established by the damped oscillation model can be used for categorization of players under their playing skills and abilities. The experimental findings suggest that players can be categorized as learners, whose damping factor is negative, and fatiguers, whose damping factor is positive. We find a strong positive correlation between amplitude and damping factor, indicating that good starters usually have higher fatigue rates, but slow starters have less fatigue and may even improve their performance during play. The proposed HA-HCI model and analytical user performance models provide a framework for developing an adaptive human-oriented HCI that enables monitoring, analysis, and increased performance of users working with physiological-computing-based user interfaces. The proposed models have potential applications in improving the usability of future human-assistive gaze-controlled interface systems.