US Renal Data System 2021 Annual Data Report: Epidemiology of Kidney Disease in the United States

Johansen, Kirsten L.; Chertow, Glenn M.; Gilbertson, David T.; Herzog, Charles A.; Ishani, Areef; Israni, Ajay K.; Ku, Elaine; Li, Shuling; Li, Suying; Liu, Jiannong; Obrador, Gregorio T.; O’Hare, Ann M.; Peng, Yi; Powe, Neil R.; Roetker, Nicholas S.; Peter, Wendy L. St.; Saeed, Fahad; Snyder, Jon J.; Solid, Craig A.; Weinhandl, Eric D.; Winkelmayer, Wolfgang C.; Wetmore, James B.

doi:10.1053/j.ajkd.2022.02.001

Cited by 167 publications

(132 citation statements)

References 7 publications

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“…Patients with ESRD have an elevated risk of site-specific cancer incidence and cancer death compared with people without ESRD, but over half of the known deaths were related to cardiovascular diseases [ 32 ]. In patients with ESRD receiving hemodialysis, the percentage of deaths attributable to cancer appears to be relatively low, accounting for 2.9% of deaths among patients with a known cause from the United States Renal Data System 2021 Annual Data Report [ 2 ]. Similarly, in this study, only 7 (5.0%) patients died of bladder cancer-associated causes compared with 24 (17.0%) patients who died of all other causes.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic kidney disease (CKD) is a substantial public health concern worldwide, with CKD stage 3–5 estimated to affect 11–13% of the general population [ 1 ]. Taiwan has the highest prevalence (3679 per million population in 2019) and the second-highest incidence (529 new cases per million population in 2019) of treated end-stage renal disease (ESRD) in the world [ 2 ]. ESRD patients on dialysis have an elevated incidence of certain cancers and death compared with the general population [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Perioperative Complications and Oncologic Outcomes after Radical Cystectomy in End-Stage Renal Disease Patients with Bladder Cancer Obtained Using a Standardized Reporting System

Liu

Hsu

et al. 2022

Cancers

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Background: We investigated the use of a standardized reporting system to study perioperative complications and oncologic outcomes after radical cystectomy in end-stage renal disease (ESRD) patients with bladder cancer. Methods: We reviewed retrospective outcomes in 141 ESRD patients with bladder cancer who underwent radical cystectomy between 2004 and 2015. Complications were graded using the Clavien–Dindo classification system with 0–2 classified as “No Major Complications” and Clavien 3–5 as “Major Complications”. Low-volume surgeons were classified as those performing fewer than nine cases during the study. Fisher’s exact test along with the chi-squared test, two-tailed t tests, logistic regression, and the Cox proportional hazard model were used to evaluate all clinically meaningful covariates. Results: Ninety-nine (99, 70.2%) patients had no major complications, and forty-two (29.8%) patients had major complications. Patients in the major complications group were older, had a higher Charlson comorbidity index (CCI), and had a longer hospitalization duration than those in the no major complications group (all, p < 0.05). Major complications were also more common when the procedure was performed by low-volume surgeons (p = 0.003). In multivariate logistic regression models, CCI ≥ 5 (p = 0.006) and low-volume surgeon (p = 0.004) were independent predictors of major complications. According to multivariate analysis with the Cox hazards regression, male sex, age > 70 years, CCI ≥ 5, bladder cancer stage ≥ 3, lymphovascular invasion, and experiencing major complications were significant poor prognostic factors for overall survival (all, p < 0.05). Conclusions: Accurate reporting of complications is necessary for preoperative counseling, identifying modifiable risk factors, and planning risk mitigation strategies. High comorbidity and low-volume surgeons were interrelated as notable risk factors for major complications. In addition to tumor-related factors, male sex, older age, and major complications significantly influence overall survival.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perioperative Complications and Oncologic Outcomes after Radical Cystectomy in End-Stage Renal Disease Patients with Bladder Cancer Obtained Using a Standardized Reporting System

Liu

Hsu

et al. 2022

Cancers

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“…The incidence of ESRD has been steadily increasing since 1980, 7 with 809 000 prevalent cases in the United States as of December 2019, of which 62.5% were treated with hemodialysis. 8 Although autologous AVF is the preferred option in most cases, 9 as of 2019, only 15.2% of patients initiate hemodialysis with an AVF, leaving the vast majority to rely on central venous catheters or synthetic grafts, which puts them at high risk for infection and thrombosis and highlights the need for new materials. 9 …”

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confidence: 99%

Bioengineering Human Tissues and the Future of Vascular Replacement

Naegeli

Kural

et al. 2022

Circulation Research

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Cardiovascular defects, injuries, and degenerative diseases often require surgical intervention and the use of implantable replacement material and conduits. Traditional vascular grafts made of synthetic polymers, animal and cadaveric tissues, or autologous vasculature have been utilized for almost a century with well-characterized outcomes, leaving areas of unmet need for the patients in terms of durability and long-term patency, susceptibility to infection, immunogenicity associated with the risk of rejection, and inflammation and mechanical failure. Research to address these limitations is exploring avenues as diverse as gene therapy, cell therapy, cell reprogramming, and bioengineering of human tissue and replacement organs. Tissue-engineered vascular conduits, either with viable autologous cells or decellularized, are the forefront of technology in cardiovascular reconstruction and offer many benefits over traditional graft materials, particularly in the potential for the implanted material to be adopted and remodeled into host tissue and thus offer safer, more durable performance. This review discusses the key advances and future directions in the field of surgical vascular repair, replacement, and reconstruction, with a focus on the challenges and expected benefits of bioengineering human tissues and blood vessels.

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“…In the United States, individuals with kidney failure treated by maintenance in-center hemodialysis (HD) treatment are a large and growing, potentially susceptible population among whom the association of long-term PM 2.5 on cardiovascular (CV) outcomes is unknown. 7 Patients receiving maintenance HD are medically fragile and have high burdens of CVD. The relative risk of death due to CV events in HD patients is 20 times higher than that of the general population.…”

mentioning

confidence: 99%

Association Between Long-term Ambient PM2.5 Exposure and Cardiovascular Outcomes Among US Hemodialysis Patients

Richardson

Kshirsagar

et al. 2022

American Journal of Kidney Diseases

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US Renal Data System 2021 Annual Data Report: Epidemiology of Kidney Disease in the United States

Cited by 167 publications

References 7 publications

Perioperative Complications and Oncologic Outcomes after Radical Cystectomy in End-Stage Renal Disease Patients with Bladder Cancer Obtained Using a Standardized Reporting System

Perioperative Complications and Oncologic Outcomes after Radical Cystectomy in End-Stage Renal Disease Patients with Bladder Cancer Obtained Using a Standardized Reporting System

Bioengineering Human Tissues and the Future of Vascular Replacement

Association Between Long-term Ambient PM2.5 Exposure and Cardiovascular Outcomes Among US Hemodialysis Patients

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