US-guided application of Nd:YAG laser in porcine pancreatic tissue: an ex vivo study and numerical simulation

Matteo, Francesco Di; Martino, Margareth; Rea, R. Lindsay; Pandolfi, M.; Panzera, Francesco; Stigliano, Egidio; Schena, Emiliano; Saccomandi, Paola; Silvestri, Sergio; Pacella, Claudio Maurizio; Breschi, L.; Perrone, Giuseppe; Coppola, Roberto; Costamagna, Guido

doi:10.1016/j.gie.2013.04.178

Cited by 46 publications

(32 citation statements)

References 16 publications

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“…Our data confirm the few ones already available in the international literature 12,13 as we agree that the best power setting is between 4 W and 6 W. Moreover, we were able to find out why in the previous studies, 12 the authors found no hemorrhage: the laser waves, in fact, allow a complete coagulation of the vessels in the area of application. The main limitations of the present study are that this is an ex vivo study and not on human tissue.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Dioscoridi¹,

Sordi²,

Breschi³

et al. 2016

Pancreas Open J

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Research ABSTRACTBackground: Pancreatic surgery is one of the most difficult and life-threatening surgical therapy especially during necrotizing pancreatitis and advanced solid neoplasms. Aim of the study: To evaluate the possibility to use ECHO Neodymium-Doped Yttrium Aluminium Garnet (ND-YAG) laser in pancreatic surgery and to establish the best power setting for the application on pancreatic tissue. Methods: An ECHO Laser ND-YAG 1064 nm, at the constant fluence of 1800 J/cm 2 was used. The laser waves were inserted inside of the samples with optical fibers of 500 micron diameter for a pre-established timing (11 min, 6 min, 4 min) in order to reach the constant fluence. Samples were, then, prepared for hystological examination. Results: At 3W power setting, the pancreatic tissue was not macroscopically modified except for an increased cutting consistency. Histological examination showed no substantial microscopical differences in pancreatic cells that appeared only partially burnt (in fact, nuclei and membranes are still recognizable). The vessels in the surrounding area have the normal morphological aspects. At 5W, macroscopically the presence of a completely burnt area, corresponding to the site of direct interaction of laser and tissue, was found and the surrounding tissue did not appear substantially modified. Histological examination showed the complete absence of cells in the burnt area and an important heat damage of the surrounding cells till the 2 th centimeter from the site of laser application. The vessels in the heat damage area appeared completely coagulated. At the power of 7 W, the burnt area was about twice than in the previous setting and histological examination showed the complete absence of cells in the burnt area and a larger heat damage of the nearest cells (till the 4 th centimeter from the application site). The vessels in heat damage area were found completely coagulated. Conclusions: A power setting between 4 and 6 W have been found as the best one for laser application on pancreatic tissue because a complete destruction of the cells in the site of application but a limited heat damage in the surrounding healthy cells have been obtained.

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Section: Discussionsupporting

confidence: 90%

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Dioscoridi¹,

Sordi²,

Breschi³

et al. 2016

Pancreas Open J

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“…Regarding the use of LA in preclinical and ex vivo settings, 12 articles have been included according to the selection criteria [18][19][20][21][22][23][24][25][26][27][28][29]. They present the use of laser light for therapy purpose, also in combination with nanotechnology ( Table 1).…”

Section: Preclinical and Ex Vivo Studiesmentioning

confidence: 99%

“…FBGs have been used also to validate the predictions of the numerical model on the thermal response of ex vivo pancreas undergoing LA [25]. Histology has been useful to estimate the damaged volumes induced in 60 ex vivo pancreases at different laser settings, and these values have been compared with the simulated results [20,26].…”

Section: Preclinical and Ex Vivo Studiesmentioning

confidence: 99%

Thermal ablation of pancreatic cancer: A systematic literature review of clinical practice and pre-clinical studies

Saccomandi

Lapergola

Longo

et al. 2018

International Journal of Hyperthermia

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Purpose: Pancreatic cancer is a challenging malignancy with low treatment option and poor life expectancy. Thermal ablation techniques were proposed as alternative treatment options, especially in advanced stages and for unfit-for-surgery patients. This systematic review describes the thermal ablative techniques-i.e., Laser (LA), Radiofrequency (RFA), Microwave (MWA) Ablation, High-Intensity Focused Ultrasound (HIFU) and cryoablation-available for pancreatic cancer treatment. Additionally, an analysis of the efficacy, complication rate and overall survival for each technique is conducted. Material and methods: This review collects the ex vivo, preclinical and clinical studies presenting the use of thermal techniques in the pancreatic cancer treatment, searched up to March 2018 in PubMed and Medline. Abstracts, letters-to-the-editor, expert opinions, reviews and non-English language manuscripts were excluded. Results: Sixty-five papers were included. For the ex vivo and preclinical studies, there are: 12 records for LA, 8 for RFA, 0 for MWA, 6 for HIFU, 1 for cryoablation and 3 for hybrid techniques. For clinical studies, 1 paper for LA, 14 for RFA, 1 for MWA, 17 for HIFU, 1 for cryoablation and 1 for hybrid techniques. Conclusions: Important technological advances are presented in ex vivo and preclinical studies, as the real-time thermometry, nanotechnology and hybrid techniques to enhance the thermal outcome. Conversely, a lack of standardization in the clinical employment of the procedures emerged, leading to contrasting results on the safety and feasibility of some analyzed techniques. Uniform conclusions on the safety and feasibility of these techniques for pancreatic cancer will require further structured investigation.

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“…These sensors have been introduced in this field more recently than thermocouples and thermistor [63,92,93]. Their main advantages are related to due to their immunity from electromagnetic fields and their MR-compatibility, which allows for using this sensor during MR-guided procedures [94].…”

Section: New Solutions To Guide Laser Ablationmentioning

confidence: 99%

Laser Ablation for Cancer: Past, Present and Future

Schena

Saccomandi

Fong

2017

JFB

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127

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Laser ablation (LA) is gaining acceptance for the treatment of tumors as an alternative to surgical resection. This paper reviews the use of lasers for ablative and surgical applications. Also reviewed are solutions aimed at improving LA outcomes: hyperthermal treatment planning tools and thermometric techniques during LA, used to guide the surgeon in the choice and adjustment of the optimal laser settings, and the potential use of nanoparticles to allow biologic selectivity of ablative treatments. Promising technical solutions and a better knowledge of laser-tissue interaction should allow LA to be used in a safe and effective manner as a cancer treatment.

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US-guided application of Nd:YAG laser in porcine pancreatic tissue: an ex vivo study and numerical simulation

Cited by 46 publications

References 16 publications

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Thermal ablation of pancreatic cancer: A systematic literature review of clinical practice and pre-clinical studies

Laser Ablation for Cancer: Past, Present and Future

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