US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention

Abstract

IMPORTANCE Asthma is the leading chronic illness in US children, but most descriptive epidemiological data are focused on prevalence. OBJECTIVE To evaluate childhood asthma incidence rates across the nation by core demographic strata and parental history of asthma. DESIGN, SETTING, AND PARTICIPANTS For this cohort study, a distributed meta-analysis was conducted within the Environmental Influences on Child Health Outcomes (ECHO) consortium for data collected from May 1, 1980, through March 31, 2018. Birth cohort data of children from 34 gestational weeks of age or older to 18 years of age from 31 cohorts in the ECHO consortium were included. Data were analyzed from June 14, 2018, to February 18, 2020. EXPOSURES Caregiver report of physician-diagnosed asthma with age of diagnosis. MAIN OUTCOME AND MEASURESAsthma incidence survival tables generated by each cohort were combined for each year of age using the Kaplan-Meier method. Age-specific incidence rates for each stratum and asthma incidence rate ratios by parental family history (FH), sex, and race/ethnicity were calculated. RESULTSOf the 11 404 children (mean [SD] age, 10.0 [0.7] years; 5836 boys [51%]; 5909 White children [53%]) included in the primary analysis, 7326 children (64%) had no FH of asthma, 4078 (36%) had an FH of asthma, and 2494 (23%) were non-Hispanic Black children. Children with an FH had a nearly 2-fold higher incidence rate through the fourth year of life (incidence rate ratio [IRR], 1.94; 95% CI, 1.76-2.16) after which the rates converged with the non-FH group. Regardless of FH, asthma incidence rates among non-Hispanic Black children were markedly higher than those of non-Hispanic White children during the preschool years (IRR, 1.58; 95% CI, 1.31-1.86) with no FH at age 4 years and became lower than that of White children after age 9 to 10 years (IRR, 0.67; 95% CI, 0.50-0.89) with no FH. The rates for boys declined with age, whereas rates among girls were relatively steady across all ages, particularly among those without an FH of asthma.CONCLUSIONS AND RELEVANCE Analysis of these diverse birth cohorts suggests that asthma FH, as well as race/ethnicity and sex, were all associated with childhood asthma incidence rates. Black children had much higher incidences rates but only during the preschool years, irrespective of FH. To prevent asthma among children with an FH of asthma or among Black infants, results suggest that interventions should be developed to target early life.

Early priming of asthma and respiratory allergies: Future aspects of prevention

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“…Some of them, sponsored by the American NHLBI, are still ongoing. 43 The remarkable success of an intervention was published last year. In a randomized placebo-controlled study in Spain, 120 preschool children with at least 3 wheezing attacks were treated for a period of 6 months with a compound of 6 different dead whole gram-positive and gram-negative bacteria.…”

Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review

“…Similar studies have been performed in the United States and the Caribbean. Following the end of the NCS, the Environmental Influences on Child Health Outcomes (ECHO) program, a collaborative consortium of 81 birth cohorts of over 90,000 participants in the United States, was established in 2016 to evaluate the rates of childhood asthma incidence due to environmental factors [ 112 ]. However, few studies on gene-environment association using the genetic analysis of the ECHO program have been reported thus far.…”

SPR Perspectives: scientific opportunities in the Environmental influences on Child Health Outcomes Program

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