Urticarial reaction to oral polyethylene glycol electrolyte lavage solution

Brullet, Enric; Morón, Alexis; Calvet, Xavier; Frías, Carmen; Sola, Joan

doi:10.1016/s0016-5107(92)70454-4

Cited by 28 publications

(15 citation statements)

References 8 publications

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“…The literature search identified 58 publications reporting adverse events in 131 patients following oral administration of either PEG (22 patients) 22–40 or NaP (109 patients) 4, 41–78 . There were an additional three reports of adverse events in five patients who had been given PEG via nasogastric tube 79–81 …”

Section: Resultsmentioning

confidence: 99%

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Systematic review: adverse event reports for oral sodium phosphate and polyethylene glycol

Belsey¹,

Epstein

Héresbach

2008

Aliment Pharmacol Ther

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Section: Resultsmentioning

confidence: 99%

“…All three patients recovered. There was one further report of a generalized urticarial rash occurring after ingestion of PEG 38 …”

mentioning

confidence: 99%

Systematic review: adverse event reports for oral sodium phosphate and polyethylene glycol

Belsey¹,

Epstein

Héresbach

2008

Aliment Pharmacol Ther

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“…AEs that have been reported include: Mallory-Weiss syndrome and esophageal perforation caused by vomiting 7 8 9 10 ; acute respiratory distress syndrome caused by aspiration pneumonia 11 ; allergy and anaphylactic shock 12 13 14 ; hyperphosphatemia 15 16 and ischemic colitis caused by peroral preparation drugs 17 18 19 . There have also been a few reports of LBO and perforation caused by bowel preparation.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of large bowel obstruction or perforation caused by oral preparation for colonoscopy

et al. 2017

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Background and study aims Patients undergoing bowel preparation for colonoscopy are at risk of potentially severe adverse events such as large-bowel obstruction (LBO) and perforation. These patients usually need emergency surgery and the consequences may be fatal. Little is known about the risk factors for LBO and perforation in these circumstances. We sought to establish the natural history of LBO and perforation caused by oral preparation for colonoscopy. Patients and methods We retrospectively analyzed data from 20 patients with LBO or perforation associated with oral preparation for colonoscopy. All patients were treated at the Showa University Northern Yokohama Hospital (SUNYH) between April 2001 and December 2015. Drugs used for bowel preparation, age, sex, indication for colonoscopy, pathogenesis and treatment were recorded. Results Eighteen of the patients had LBO and 2 had perforation. Fourteen events occurred at SUNYH, which accounted for 0.016 % of patients who underwent bowel preparation during this period. Seventeen patients were symptomatic when the decision to undertake colonoscopy was made (including 7 who complained of constipation and 4 who complained of abdominal pain; 3e were asymptomatic). Nineteen patients ultimately required surgery, 13 within 3 days of presentation. Eleven patients ultimately required colostomy. There was no perioperative mortality in our cases. Conclusion Large bowel obstruction and perforation are rare events associated with oral preparation for colonoscopy, but frequently require surgery. Exacerbation of constipation might be a risk factor for LBO or perforation. Potentially catastrophic situations can be avoided by early detection and treatment.

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“…[3] reported case presenting with hypotension and flushing. Brullet et al [4] and Haneda et al [5] reported a case presenting with urticaria. Julia et al had presented a case with biphasic presentation of allergic symptoms.…”

Section: Introductionmentioning

confidence: 99%

Rare Complication of a Commonly Performed Procedure : The Peg Allergy

Murugesan¹,

Pichaimuthu²,

Perumal³

et al. 2015

jemds

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CASE REPORT: Anaphylaxis to oral PEG. BACKGROUND: Mechanical Bowel preparation (MBP) is commonly practised for patients prepared for major abdominal surgeries and colonoscopies. Patients with periampullary tumour planned for pancreaticoduodenectomy had their bowel prepared the day before surgery. The importance of this case report is to highlight the rarest of complications of a seemingly innocuous and commonly performed procedure CASE REPORT: A 47 year old female, a case of periampullary carcinoma with no comorbid illness, was planned for pancreaticoduodenectomy. She had features of obstructive jaundice with cholangitis for which endoscpoc biliary stenting was done. Following consumption of oral PEG solution the day before surgery, patient developed rash, hypotension and breathing difficulty which necessitated ICU admission and postponement of proposed surgery. CONCLUSION: Our case highlights a rare but potentially life threatening adverse reaction to PEG solutions. A greater awareness of this rare complication is essential for the treating physicians to effectively manage this entity.

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Urticarial reaction to oral polyethylene glycol electrolyte lavage solution

Cited by 28 publications

References 8 publications

Systematic review: adverse event reports for oral sodium phosphate and polyethylene glycol

Systematic review: adverse event reports for oral sodium phosphate and polyethylene glycol

Retrospective analysis of large bowel obstruction or perforation caused by oral preparation for colonoscopy

Rare Complication of a Commonly Performed Procedure : The Peg Allergy

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