Urticaria after topical immunotherapy with diphenylcyclopropenone

Francomano, Mariangela; Seidenari, Stefania

doi:10.1034/j.1600-0536.2002.4705102.x

Cited by 15 publications

(8 citation statements)

References 18 publications

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“…A literature search regarding adverse effects of diphenylcyclopropenone highlights known adverse effects of the medication, such as urticaria. 7,8 This specific patient case offers insight into another adverse event not previously seen with high-dose diphenylcyclopropenone. Because the patient had no significant past medical history and did not take any other home medications, there were no confounding variables for his scalp angioedema.…”

Section: Discussionmentioning

confidence: 99%

Extensive Scalp Angioedema following High-Dose Diphenylcyclopropenone for Alopecia Areata

2014

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Objective: To describe a case of an unusual adverse drug reaction to diphenylcyclopropenone for the treatment of alopecia areata. Case summary: A 31-year-old Caucasian male presented with extensive angioedema to the head with neck involvement 10 days following treatment with diphenylcyclopropenone 2% solution in acetone topically on his scalp to treat alopecia areata. Findings on patient presentation included edema of the soft tissues (deeper dermis and subcutaneous tissue) of the head and face with mild neck involvement, acute inflammatory changes from chemical-induced irritation, scalp erythema, and serous fluid drainage from inflamed and fissured edematous scalp. Acute treatments used for control of the reaction included intravenous steroids and antihistamines during hospitalization followed by oral steroids and antihistamines for maintenance during outpatient treatment of the resolving condition. Discussion: The role of topical diphenylcyclopropenone in this case of alopecia areata is probable according to the Naranjo criteria, with a score of 8. Diphenylcyclopropenone is not approved by the US Food and Drug Administration, but it has been used by many clinicians for the treatment of alopecia areata. Diphenylcyclopropenone causes an allergic contact dermatitis in the area of hair loss. In general, diphenylcyclopropenone is applied at a high concentration of 2% once and then at lower concentrations once weekly after the sensitization dose. This patient applied the 2% concentration on multiple consecutive days. Conclusion: Frequent use of topical diphenylcyclopropenone 2% applied to the scalp may cause scalp angioedema.

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Section: Discussionmentioning

confidence: 99%

Extensive Scalp Angioedema following High-Dose Diphenylcyclopropenone for Alopecia Areata

2014

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“…SADBE is applied once or twice per week 16,17. The adverse effects to topical sensitizers include cervical lymphadenopathy, a severe eczematous reaction, urticaria, and postinflammatory pigment changes 18,19…”

Section: First-line Therapiesmentioning

confidence: 99%

Alopecia areata: a new treatment plan

Alsantali

2011

CCID

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Many therapeutic modalities have been used to treat alopecia areata, with variable efficacy and safety profiles. Unfortunately, none of these agents is curative or preventive. Also, many of these therapeutic agents have not been subjected to randomized, controlled trials, and, except for topical immunotherapy, there are few published studies on long-term outcomes. The treatment plan is designed according to the patient’s age and extent of disease. In this paper, the therapeutic agents are organized according to their efficacy and safety profiles into first-line, second-line, and third-line options.

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“…To our knowledge, only five papers have been reported in the English literature on urticaria as a side‐effect of topical DCP therapy for alopecia and viral warts 1–4 . Although most papers have suggested that urticaria is a rare side‐effect of topical DCP therapy, the data from our patients suggest that urticaria may be a long‐lasting side‐effect and not rare.…”

Section: Demographics and Clinical Features Of The Patients Who Showementioning

confidence: 65%

Prospective study of urticaria after diphencyprone therapy in patients with viral warts

Choi¹,

Seo²,

Kim³

et al. 2007

Int J Dermatology

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Urticaria after topical immunotherapy with diphenylcyclopropenone

Cited by 15 publications

References 18 publications

Extensive Scalp Angioedema following High-Dose Diphenylcyclopropenone for Alopecia Areata

Extensive Scalp Angioedema following High-Dose Diphenylcyclopropenone for Alopecia Areata

Alopecia areata: a new treatment plan

Prospective study of urticaria after diphencyprone therapy in patients with viral warts

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