Urtica dioica Induces Cytotoxicity in Human Prostate Carcinoma LNCaP Cells: Involvement of Oxidative Stress, Mitochondrial Depolarization and Apoptosis

Levy, Arkene; Sivanesan, D.; Ramalingam, Murugan; Jornadal, J; Quinonez, Y; Jaffe, Mark; Rathinavelu, Appu

doi:10.4314/tjpr.v13i5.9

Cited by 15 publications

(20 citation statements)

References 22 publications

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“…Nettle is known to boost the immune system and to prevent anaemia [5]. It is suggested to treat hypertension and heart diseases [6], to inhibit the growth of breast [7], prostate [8], and lung [9] tumor cells. It may reduce the symptoms of Alzheimer's disease [10] and respiratory allergies [11].…”

Section: Introductionmentioning

confidence: 99%

Changes in Total Polyphenol Content and Antioxidant Capacity of Stinging Nettle (Urtica dioica L.) from Spring to Autumn

Kőszegi

Békássy-Molnár

Koczka

et al. 2019

Period. Polytech. Chem. Eng.

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Total polyphenol content and antioxidant/reducing capacity of stinging nettle (Urtica dioica L.) leaves and roots collected from wild-grown plants were investigated during the vegetation period. From both fresh and dried samples of leaves and roots, water extracts were prepared by brewing at 60, 80 and 100 °C for 3 hours, and ethanolic extracts of 20 % (v/v) and 70 % (v/v) by extracting at room temperature for 72 hours. The total polyphenol content was determined spectrophotometrically with Folin-Cioceltau reagent and the antioxidant capacity was measured by ferric reducing ability of plasma (FRAP) assay. Our results showed that the optimal harvest time is in the spring (April). Water extracts had the highest total polyphenol content and antioxidant capacity in this period. The amount of valuable compounds released increased by higher extraction temperature in both plant parts. In water extracts of nettle leaves, two times higher polyphenol content was obtained than in that of roots. Both kind of ethanolic extractions resulted in a higher polyphenol content in the leaves harvested in the spring period. For the roots, it was higher for samples collected in the autumn, which is also reflected in the values of antioxidant capacity. Water extracts of fresh leaves harvested in April had more than twice higher total polyphenol content than in October. For dried samples, raising the temperature did not cause a significant change in the total polyphenol content, however, it has resulted in increased antioxidant capacity both for the dried leaf and root samples.

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Section: Introductionmentioning

confidence: 99%

Changes in Total Polyphenol Content and Antioxidant Capacity of Stinging Nettle (Urtica dioica L.) from Spring to Autumn

Kőszegi

Békássy-Molnár

Koczka

et al. 2019

Period. Polytech. Chem. Eng.

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“…The extract of Urtica dioica have been screened to have anti-inflammatory activity due to inhibition of pro-inflammatory transcription factor NF-κB due to presence of high phenolic contents and this activity is found in ethanolic extract of U. urens due to presence of Chlorigenic acid 57 .…”

Section: Folk Language: Shisuunmentioning

confidence: 99%

“…The extract shows significant reduction in LNCaP cell viability in a dose dependent manner, thus shows cytotoxic effect using MTT Assay 57 . The extract has been used as complementary and alternative therapies during and after the chemotherapic treatment of cancer patients 59 .…”

Section: Folk Language: Shisuunmentioning

confidence: 99%

“…Aerial part Amino acid-Aspartic acid, Threonine, Serine and Alanine 19 Chlorigenic acid 57 Anti-inflammatory 57 Hepato-protective, Antioxidant 63 Antirheumatoid arthritis 65 Root lignans -(+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3, 4-divanillyl-tetrahydro-furan 22 Antiprostatic hyperplasic 54 …”

Section: Urtica Urensmentioning

confidence: 99%

“…carotenoid such as β-carotene, hydroxyl-β-carotene, lucoxanthin, lutein-epoxide and violaxanthin 30 Anti-diabetic, Anti-inflammatory, Antiapoptotic, Cytotoxic, Anticancerous 57 Seed Fatty acid-Palmitic, stearic, Oleic, Linoleic and Eicosenoic acid, Amino acid Aspartic acid, threonine, serine Essential oils-Carvacrol, carvone, napthelene, Phytol 19 Anti-diabetic, Antiinflammatory 47 Stinging hairs formic acid, histamine,serotonin 93 …”

Section: Leafmentioning

confidence: 99%

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