Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes

Fontanay, Stéphane; Grare, Marion; Mayer, Joséphine; Finance, C.; Duval, Raphaël E.

doi:10.1016/j.jep.2008.09.001

Cited by 227 publications

(158 citation statements)

References 17 publications

(33 reference statements)

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“…From the clinical perspective, very important results were obtained by Horiuchi and coworkers who reported the strong activity of OA and UA isolated from Salvia officinalis (Lamiaceae) extract against VRE (vancomycin-resistant enterococci) with MIC value of 8 mg mL -1 [28]. This result was confirmed for the reference strain, Enterococcus faecalis ATCC 28212 [21] (Table 1). Olean-27-carboxylic acid-type triterpenes extracted from the root portion of Aceriphyllum rossi (Saxifragaceae) which is a staple food in Korea, exhibited potent antibacterial activity against several strains of MRSA (methicillin-resistant S. aureus) and quinolone-resistant Staphylococcus aureus [29].…”

Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 70%

“…It should be mentioned that so far there are no rules recommended for the validation of OA and UA antibacterial activity. According to Fontanay and coworkers [21] MICs values below 10 mg mL -1 define "good" and those around 50 mg mL -1 "moderate" antibacterial activity. MICs values that equal hundreds of mg mL -1 indicate that the compound is devoid of activity.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used antibiotics are no longer effective.Thus, there is considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic acid (UA) and their derivatives. These compounds can be isolated from many medicinal and crop plants and their antibacterial, antiviral, antiulcer and anti-inflammatory effects are well documented. OA and UA are active against many bacterial species, particularly Gram-positive species, including mycobacteria. They inhibit bacterial growth and survival, and the spectrum of minimal inhibitory concentration (MIC) values is very broad. In addition, OA, UA and their derivatives display potent antimutagenic activity. Studies to identify the cellular targets and molecular mechanisms of OA and UA action were initiated a few years ago and it has already been demonstrated that both acids influence bacterial gene expression, the formation and maintenance of biofilms, cell autolysis and peptidoglycan turnover. Before these compounds can be used clinically as antimicrobial agents, further extensive studies are required to determine their cytotoxicity and the optimum mode of their application.

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Section: Antibacterial Activity Of Oa and Its Derivativesmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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“…31,67 Known as 3β-hydroxy-urs-12-en-28-oic-acid, this metabolite has protective properties against fatty liver induced by high-lipid diet and liver injury as well as anti-bacterial, anti-inflammatory and antioxidative properties. [67][68][69][70][71] Oleanolic acid, an ursolic acid isomer, is found in over 1620 plant species. 72 This compound, predominant in the Oleaceae family, exhibits several biological activities, such as hepatoprotective, anti-inflammatory, antioxidant and anti-tumor.…”

Section: Pentacyclic Triterpenesmentioning

confidence: 99%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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Senna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigations have shown that S. spectabilis produces over 40 constituents from different biosynthetic pathways, including piperidine alkaloids, pentacyclic terpenoids and anthraquinones, displaying antiproliferative, antitumoral and antifungal activities. Moreover, studies have also been conducted to identify endophytic and rizhospheric microorganisms associated to S. spectabilis and their chemical composition, enabling further elucidation of cadinane sesquiterpenoids, cytochalasins, depsipeptides and dibenzopirones. This review aims to provide an updated summary of the main features of S. spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and its associated microorganisms.

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“…H. albida has ursolic, betulinic, and oleanolic acids (Pereda-Miranda et al, 1990b), which inhibit S. aureus (ursolic acid, MIC = 8g/ml; betulinic acid, MIC = 64 g/ml; oleanolic acid, MIC = 32g/ml) and E. faecalis (ursolic and oleanolic acids, MIC = 4 and 8 g/ml, respectively) (Fontanay et al, 2008;Chung et al, 2014). Despite these reports, our current research is focused on the isolation of different molecules responsible for the inhibitory properties of H. albida against sensitive and methicillinresistant S. aureus and E. faecalis.…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Screening for antibacterial and antiprotozoal activities of crude extracts derived from Mexican medicinal plants

Garcia¹,

Mata-Cardenas²,

Garza-Gonzalez³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Crataegus mexicana, Hyptis albida, Larrea tridentata, Ocimum baislicum, Prunus serotina, and Smilax spp. are used in Mexican traditional medicine to treat respiratory and gastrointestinal diseases such as flu, cough, diarrhea, dysentery, and other parasitic or microbial infections. Therefore this study was aimed at the pharmacological prospection of these plants against eleven bacterial species and three amitochondrial protist pathogens. Material and methods:The fruits or aerial parts of C. mexicana, H. albida, L. tridentata, O. baislicum, P. serotina, and Smilax spp. were extracted with different solvents. The antibacterial properties of organic and aqueous extracts of these plants were determined by the microdilution method and the microplate alamar blue assay against Stenotrophomonas maltophilia, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae, Staphylococcus aureus, methicillin-resistant S. aureus, Listeria monocytogenes, Enterococcus faecalis, and Mycobacterium tuberculosis, whereas anti-protozoal activities of extracts were evaluated by a vial micro-assay against strains of Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia. Results: H. albida, Smilax spp, and C. mexicana showed good activity against the Gram-positive strains, S. aureus, methicillin-resistant S. aureus, and E. faecalis. Four extracts (C. mexicana, H. albida, O. basilicum, and L. tridentata) showed good activity against E. histolytica, T. vaginalis, and G. lamblia. Conclusion:The extracts of these six medicinal plants could be a source for new antibacterial and antiprotozoal drugs. For this reason they are currently under investigation to isolate and characterize their active compounds.

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Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes

Cited by 227 publications

References 17 publications

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Update: Biological and Chemical Aspects of Senna spectabilis

Screening for antibacterial and antiprotozoal activities of crude extracts derived from Mexican medicinal plants

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