Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress

Li, Jian-Shuang; Wang, Wenjun; Sun, Yu; Zhang, Yuhao; Zheng, Ling

doi:10.1039/c5fo00083a

Cited by 60 publications

(42 citation statements)

References 48 publications

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“…But, nowadays many results showed UA may ameliorate disease progression in patients with NAFLD. Li et al (2015) suggested that UA treatment (10-30 lg/mL) inhibited the development of NAFLD via increasing lipid b oxidation and inhibiting the hepatic endoplasmic reticulum stress. Jia et al (2011) showed that UA was a PPAR-a agonist which regulated hepatic lipid metabolism and, therefore, significantly reduced intracellular triglyceride concentrations in hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

Huang

Chen

Ren

et al. 2016

Pharmaceutical Biology

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Context: Hepatocellular carcinoma (HCC) is a common cancer around the world, with high mortality rate. Currently, there is no effective drug for the therapy of HCC. Ursolic acid (UA) is a natural product which exists in various medicinal herbs and fruits, exhibiting multiple biological effects such as its outstanding anticancer and hepatoprotective activity, which has drawn many pharmacists' attention. Objective: This paper summarizes the current status of the hepatoprotective activity of UA analogues and explains the related mechanism, providing a clear direction for the development of novel anti-HCC drugs. Methods: All of the data resources were derived from PubMed. By comparing the IC 50 values and analyzing the structure-activity relationships, we listed compounds with good pharmacological activity from the relevant literature, and summarized their anti-HCC mechanism. Results: From the database, 58 new UA derivatives possessing wonderful anticancer and hepatoprotective effects were listed, and the relevant anti-HCC mechanism were discussed. Conclusion: UA's anti-HCC effect is the result of combined action of many mechanisms. These 58 new UA derivatives, particularly compounds 45 and 53, can be used as potential drugs for the treatment of liver cancer. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

Huang

Chen

Ren

et al. 2016

Pharmaceutical Biology

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“…RNA was extracted from cells using RNAiso Plus (Takara Biotechnology, 9109) as previously described37. cDNA synthesis was performed using the M-MLV First Strand Kit (Invitrogen, 28025-021).…”

Section: Methodsmentioning

confidence: 99%

Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment

Wang

Zhang

Wang

et al. 2017

Sci Rep

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In this study we quantified the alterations of retinal histone post-translational modifications (PTMs) in diabetic rats using a liquid chromatography - tandem mass spectrometry (LC-MS/MS) approach. Some diabetic rats were subsequently treated with minocycline, a tetracycline antibiotic, which has been shown to inhibit the diabetes-induced chronic inflammation in the retinas of rodents. We quantified 266 differentially modified histone peptides, including 48 out of 83 methylation marks with significantly different abundancein retinas of diabetic rats as compared to non-diabetic controls. About 67% of these marks had their relative abundance restored to non-diabetic levels after minocycline treatment. Mono- and di-methylation states of histone H4 lysine 20 (H4K20me1/me2), markers related to DNA damage response, were found to be up-regulated in the retinas of diabetic rats and restored to control levels upon minocycline treatment. DNA damage response biomarkers showed the same pattern once quantified by western blotting. Collectively, this study indicates that alteration of some histone methylation levels is associated with the development of diabetic retinopathy in rodents, and the beneficial effect of minocycline on the retinas of diabetic rodents is partially through its ability to normalize the altered histone methylation levels.

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“…UA inhibited the progression of non-alcoholic fatty liver disease, with a decrease in liver weight and hepatic steatosis, as well as accumulation of intracellular lipids, possibly due to an increase in lipid b-oxidation and inhibition of hepatic stress. [22] Cardioprotective effect…”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Characteristics, Biological Properties and Analytical Methods of Ursolic Acid: A Review

Pironi

Araújo

Fernandes

et al. 2017

Critical Reviews in Analytical Chemistry

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Ursolic acid (UA) is a naturally occurring triterpenoid which is a promising candidate for the development of new therapeutic approaches and for the prevention and treatment of several diseases owing to its pharmacological importance. However, its low solubility in aqueous medium affects its therapeutic application. Several strategies have been used to overcome this obstacle. In this study, the incorporation of UA in to different drug delivery systems was found to be highly efficient. In addition, important investigations were performed about methods for qualitative and quantitative analyses of UA in various raw materials, including plants, biological fluids, and drug delivery systems, were investigated. Most recently high performance liquid chromatography coupled with various detectors, gas chromatography-mass spectrometry and capillary electrophoresis were used for this purpose. Thus, this review was performed to evaluate the biological effects of UA demonstrated thus far as well as the currently used, delivery systems and analytical methods.

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Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress

Cited by 60 publications

References 48 publications

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment

Characteristics, Biological Properties and Analytical Methods of Ursolic Acid: A Review

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