Ursachen der St�rungen im Kohlenhydratstoffwechsel unter dem Einflu� sulfonamidierter Diuretica

Senft, G.; Losert, Wolfgang; Schultz, Günter; Sitt, R.; Bartelheimer, H

doi:10.1007/bf00593171

Cited by 44 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the results it can be seen that frusemide treatment in the mouse was capable of producing an acute hyperglycaemic response as previously demonstrated in the rat (Foy, 1967;Wales et al, 1968 Senft et al (1966) and Guidox (1969) although, using the rat, other workers (Tabachnick et al, 1965;Foy, 1967) have shown hydrochlorothiazide to produce an acute hyperglycaemic response.…”

Section: Discussionsupporting

confidence: 75%

“…The effects of hydrochlorothiazide have also been investigated, since conflicting reports appear in the literature conceming the ability of diuretic benzothiadiazine derivatives to produce hyperglycaemia in the normal rat after acute administration (Watson, van Pelt & Winter, 1964;Senft, Losert, Schultz, Sitt & Bartelheimer, 1966;Tabachnick et al, 1965;Foy, 1967;Guidox, 1969).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of diuretics on mouse blood sugar following single dose administration

Foy

Furman

1971

British J Pharmacology

View full text Add to dashboard Cite

Summary Frusemide, in doses which were maximal or supramaximal in respect of its natriuretic, diuretic and kaliuretic properties, produced a dose dependent, transient hyperglycaemic response in the mouse. Bilateral nephrectomy resulted in a complete abolition of the hyperglycaemic response. The hyperglycaemic response was accompanied by a decrease in liver glycogen and was significantly attenuated by adrenalectomy, adrenal demedullation and pretreatment with dihydroergotamine (DHE). In the nephrectomized mouse frusemide treatment produced a marked reduction in intravenous glucose tolerance and a reduction in the plasma concentration of immunoreactive insulin following glucose administration. The drug had no detectable effect upon insulin sensitivity. Hydrochlorothiazide exerted no detectable effect on mouse blood sugar. Ethacrynic acid hyperglycaemia was obtainable after intraperitoneal or intramuscular injection, but not after intravenous injection. Intravenously administered ethacrynic acid exerted no effect upon intravenous glucose tolerance or insulin sensitivity in the nephrectomized mouse.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Effect of diuretics on mouse blood sugar following single dose administration

Foy

Furman

1971

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…This could be due either to a higher rate of formation or to a reduced rate of disintegration. It may be speculated that indapamide, like other thiazide diuretics, increases cyclic adenosine S'S'-monophosphate 26 due to inhibition of phosphodiesterase, which stimulates lipolysis in fatty tissue. 27 Free fatty acids would be released into the plasma and could be used for synthesis of VLDL in the liver.…”

Section: -173mentioning

confidence: 99%

Serum lipoprotein levels during long-term treatment of hypertension with indapamide.

Meyer‐Sabellek¹,

Gotzen²,

Heitz³

et al. 1985

Hypertension

View full text Add to dashboard Cite

SUMMARY The beneficial effect of antihypertensive pharmacotherapy in decreasing morbidity and mortality in hypertensive patients may be counteracted by metabolic and biochemical disturbances, such as hypokalemia, hyperglycemia, hyperuricemia, and hyperlipoproteinemia, that occur with the administration of thiazides and related diuretics. Antiatherogenk high-density lipoprotein cholesterol may be unchanged, whereas the potentially atherogenic low-density lipoprotein cholesterol may be increased by long-term therapy with thiazide diuretics. Indapamide is a methylindoline antihypertensive diuretic with a considerable peripheral vasodilatory effect. At a low dose of 2.5 mg daily, it did not alter total circulating cholesterol, in contrast to chlorthalidone. High-density lipoprotein cholesterol levels increased significantly in 20 hypertensive men after 6 months of therapy with indapamide, resulting in a significant fall of the low-density lipoprotein/high-density lipoprotein ratio, an atherogenic risk factor, regardless of preexisting lipid disorders. (Hypertension 7 [Suppl IT]: II-170-H-174, 1985) KEY WORDS • total body potassium • high-density lipoprotein cholesterolM ULTICENTER trials 13 demonstrated the beneficial effect of antihypertensive pharmacotherapy in decreasing morbidity and mortality in patients with high blood pressure, including mild hypertension. Long-term antihypertensive therapy with thiazides and related diuretics has been associated with distinct biochemical side effects, including changes in total body potassium, 4 hypokalemia, 5 hyperglycemia, 6 and hyperuricemia, 7 and to a lesser degree, decreased glucose tolerance and worsening diabetes mellitus. 8 More recent studies 9 "" focused on impaired lipid metabolism due to long-term therapy with sulfonamide diuretics. Weidmann et al. 12 showed that hydrochlorothiazides and chlorthalidone increase plasma triglycerides and total cholesterol in mildly hypertensive patients. Other investigations also demonstrated a tendency to increased triglyceride and/or total cholesterol levels in patients treated with thiazide diuretics."" 13 Significant increase of the potentially atherogenic serum low-density lipoprotein (LDL) cholesterol accom- panied by a possible increase of very low-density lipoprotein (VLDL) cholesterol fractions may be detected with long-term treatment with thiazide diuretics, whereas the level of antiatherogenic high-density lipoprotein (HDL) cholesterol remains unchanged. It is therefore of considerable importance to study lipoproteins, which are probably more important correlates of atherogenesis than lipid levels per se with any longterm diuretic and/or antihypertensive therapy.Miller et al. w were among the first to note an inverse correlation between HDL cholesterol and the prevalence of coronary heart disease (CHD). Data generated from the Framingham Study 13 showed that the cholesterol ratio (total cholesterol to HDL cholesterol) was higher among men and women with clinical evidence of CHD than among those with standard risk factor...

show abstract

“…The early investigations by Senft (1966) showed that neither single-dose nor long-term administration of frusemide (200 mg kg-' body weight) to rats affected serum glucose or serum insulin levels. Later studies have indicated that single-dose administration to mice (Foy & Furman, 1971) or rats (Wales et al, 1968;Aynsley-Green & Alberti, 1973;Wexler, 1981) can elicit a transient hyperglycaemia.…”

Section: Introductionmentioning

confidence: 99%

Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice

Sandström

1986

British J Pharmacology

View full text Add to dashboard Cite

1 The effect of probenecid on frusemide-induced diuresis and hyperglycaemia was studied in mice. 2 Probenecid, a known inhibitor of tubular secretion of organic anions in the kidney, strongly reduced the diuretic response to frusemide (25 or 200 mg kg-' body weight). This effect of probenecid appeared to be dose-dependent up to 240 mg kg-' body weight, at least at the lower concentration of frusemide. 3 Pretreatment with probenecid (240 mg kg-' body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg-' body weight). 4 The results show that probenecid has opposite effects on frusemide-induced diuresis and hyperglycaemia in mice. It is suggested that the acute hyperglycaemic effect of frusemide is not directly linked to diuresis.

show abstract

Ursachen der St�rungen im Kohlenhydratstoffwechsel unter dem Einflu� sulfonamidierter Diuretica

Cited by 44 publications

References 17 publications

Effect of diuretics on mouse blood sugar following single dose administration

Effect of diuretics on mouse blood sugar following single dose administration

Serum lipoprotein levels during long-term treatment of hypertension with indapamide.

Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice

Contact Info

Product

Resources

About