Urothelial Dysplasia Concomitant With Bladder Tumours: A Determinant for Future New Occurrences in Patients Treated by Full-Course Radiotherapy

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

“…However, dysplasia of the bladder epithelium in man is often detected in association with rather than preceeding a carcinoma (Murphy, 1989). As in our study, such dysplasia is frequently associated with invasive and aggressive types of transitional cell carcinoma, and dysplastic lesion in bladders treated for carcinoma may predict a recurrence of the disease (Murphy, 1989;Wolf et al, 1985;Kakizoe et al, 1985). The close association reported here between expression of p53 protein in dysplasia and the related transitional cell carcinomas suggests that these processes may be linked together in mechanism.…”

Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

“…Although ted that cyclin Dl is metastasis is less common with superficial bladder cancers, such cell cycle (Xiong et al, tumours may progress and the majority will recur and require s involved in cell cycle additional treatment. It is generally accepted that patients with TI, ) and other cell cyclemultiple, large or high-grade tumours are at greater risk of recurfinds et al, 1992; Xiong rence (Heney et al, 1983;Wolf et al, 1985). In this study, we assessed the probability of disease-free survival in the 53 superostic significance of the ficial tumours according to the overexpression of cyclin Dl.…”

The Significance of Bladder Quadrant Biopsies in Patients with Primary Superficial Bladder Carcinoma

“…In addi tion, the presence of a malignant tumor (Tis) or dysplas tic changes (D I-III) in the remaining bladder mucosa were all evaluated to determine their prognostic rele vance [9][10][11].…”