Urothelial Changes of the Renal Papillae in Sprague‐dawley Rats Induced by Long Term Feeding of Phenacetin

Abstract

Johansson, S. & Angervall, L. Urothelial changes of the renal papillae in Sprague-Dawley rats induced by long term feeding of phenacetin. Acta path. microbiol. scand. Sect. A, 84: [375][376][377][378][379][380][381][382][383] 1976.Thirty female Sprague-Dawley rats were fed 0.535 per cent phenacetin in the diet for up to 110 weeks. Twenty-six of these rats developed urothelial hyperplasia, partly papillary, of the renal papillae. Twenty-eight rats showed dilatation of the vasa recta frequently associated with thrombus formation and calcification. One phenacetin fed rat had epithelial hyperplasia associated with chronic pyelitis. I n 2 of the 30 control rats urothelial hyperplasia was found to be associated with chronic pyelitis. The hyperplastic urothelial changes and vascular changes were often, but not always, present simultaneously. One control rat developed a mammary carcinoma, as compared with 5 rats in the phenacetin group. Four phenacetin fed rats developed carcinoma of the ear duct. The results of the present investigation provide evidence that phenacetin can induce proliferative lesions of the urothelium of the rat renal pelvis with weak carcinogenic activity in the ear duct and mammary glands.

Phytate acts as an inhibitor in formation of renal calculi

“…Development of these calcified areas appears to depend on injury or a pre-existing lesion such as papillary necrosis which leads to intratubular calcium phosphate deposits (29). Papillary calcification can be induced in rats with a combination of aspirin and sodium saccharin (30,31) and calcification of the vasa recta can be induced by long term phenacetin (32). Other studies demonstrated that high doses of phenylbutazone, oxyphenbutazone and indomethacin in rats leads to tubular necrosis in the lower nephron and causes calcification (33).…”