Urothelial carcinoma with villoglandular differentiation: a study of 14 cases

Lim, Matthew; Adsay, Volkan; Grignon, David J.; Osunkoya, Adeboye O.

doi:10.1038/modpathol.2009.97

Cited by 48 publications

(42 citation statements)

References 19 publications

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“…Therefore, we decided to use the preferred term of flat carcinoma in situ with glandular differentiation (CISg) to refer to this entity thus avoiding misunderstanding with precursor lesions of invasive adenocarcinoma which are not in the scope of this study . None of the previously reported cases had associated pure invasive adenocarcinoma or villous adenoma nor developed these lesions on follow-up [1][2][3]13,15], similar to the cases reported in the current series.…”

Section: Discussionsupporting

confidence: 88%

“…Carcinoma in situ (high-grade intraurothelial neoplasia) refers to a flat noninvasive neoplastic change of the urothelium with substantial architectural and cytological abnormalities, the latter being indistinguishable from those of carcinoma [10,11,13,19,20]. Primary or isolated CIS accounts for less than 10% of cases of CIS, and 1% of bladder tumors [10,11,13,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Primary or isolated CIS accounts for less than 10% of cases of CIS, and 1% of bladder tumors [10,11,13,19,20]. Secondary or concomitant CIS is more common than primary CIS, accounting for 90% of cases [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…None of the reported cases had immunohistochemical evaluation, therefore making the immunophenotype of CISg virtually unknown [1,2]. Hence, more reports on larger series are needed to elucidate the clinical significance, immunophenotype and differential diagnostic implications of this morphologic variant of bladder CIS [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Flat urothelial carcinoma in situ of the bladder with glandular differentiation

et al. 2011

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Flat urothelial carcinoma in situ of the bladder with glandular differentiation

et al. 2011

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“…The bladder lesions showed male preponderance than female accounting for 51.1% and 48.9% of the cases respectively. Our observations are in accordance with Lim et al [14] and Vaidya et al [12]. The increased prevalence of bladder lesions in males observed in our study could be attributed to cigarette smoking, industrial exposure to acrylamine, schistosoma haematobium, cyclophosphamide, artificial sweetners and long acting analgesics.…”

Section: Citationsupporting

confidence: 93%

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2016

ICPJL

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Introduction: Urinary bladder lesions constitute an important source of clinical signs and symptoms which are more disabling than lethal. The present study aimed to study the frequency of bladder lesions and to study the clinicohistomorphological features of various bladder lesions with special emphasis on grading and staging of the bladder tumours. Materials and methods:The present study is a 3 years prospective study carried out in the department of pathology. All patients who visited to urology outpatient department with lower urinary tract symptoms and obstructive bladder symptoms were subjected to cystoscopy. The detailed clinico-histomorphological features of cystoscopy biopsies are studied using WHO/ISUP 2004 histological grading and TNM staging are used in classifying the bladder tumours.Results: Out of 139 cystoscopy biopsies, the non-neoplastic bladder lesions constituted 26.6 % and neoplastic lesions constituted 73.38%. Among the neoplastic, benign lesions showed 10.79% of the cases and malignant lesions showed 62.58% of the cases. Among the malignant lesions, urothelial carcinoma was the commonest accounting for 55.39% of the cases with increased prevalence of high grade papillary urothelial carcinoma (55.43%) and invasive papillary urothelial carcinoma accounting for 78.25% of the cases. Conclusions:The present study has stressed the importance of Histopathological examination with special emphasis on the study of serial sections, inclusion of smooth muscle in the biopsy for accurate grading and staging so as to decrease the mortality and morbidity due to bladder tumours. All the patients who visited the urology outpatient department (OPD) with lower urinary tract symptoms and obstructive urinary symptoms were included in the study. After the informed written consent of the patients, fiberoptic cystoscopy bladder biopsies were taken from the walls of the bladder. The cystoscopic bladder biopsies taken were fixed in 10% buffered formalin and then processed with embedding in paraffin wax. Four microns thick sections were taken and stained with regular haematoxylin and eosin stain (H and E). The study of biopsy specimens along with the histomorphological changes under low and high power magnification were studied by light microscope. The WHO/ISUP -2004 grading system was used to grade the bladder neoplasms 7 and staging was done according to TNM staging [7]. Keywords:Inclusion criteria: All the transurethral resection of bladder tissue (TURBT) biopsies received in the department of pathology.Exclusion criteria: Autolysed and inadequate biopsies were excluded. ResultsOut of total 139 cases, 71cases (51.1%) were males and 68 cases (48.9%) were females with peak age incidence is between 60-69 years as shown in graph 1. In the study, we found that the majority of the patients with benign lesions presented with lower urinary tract symptoms (LUTS) accounting for 82.7% of the cases and those with malignant lesions present with haematuria accounting for 90.8% of the cases as shown in graph 2. The detai...

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