Urothelial Carcinoma with Squamous Differentiation is Associated with High Tumor Stage and Pelvic Lymph-Node Metastasis

Liu, Yunguang; Bui, Marilyn M.; Xu, Bo

doi:10.1177/107327481702400113

Cited by 44 publications

(33 citation statements)

References 26 publications

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“…Some cases have urothelial carcinoma in situ as the only urothelial component. Cases with areas of squamous differentiation may have a less favourable response to therapy than pure urothelial carcinoma, which seems to be related to a more advanced stage at presentation …”

Section: Urothelial Carcinoma With Divergent Differentiationmentioning

confidence: 99%

“…Current literature provides increasingly valuable data on the clinical significance and therapy‐related issues concerning urothelial carcinoma with variant histology compared to conventional urothelial carcinoma. In general, variant urothelial carcinoma is considered an aggressive feature as it worsens overall survival due to a higher rate of upstaging after surgery . Gofrit et al .…”

Section: Variant Urothelial Carcinoma In Clinical Practicementioning

confidence: 99%

“…Cases with areas of squamous differentiation may have a less favourable response to therapy than pure urothelial carcinoma, which seems to be related to a more advanced stage at presentation. [14][15][16][17][18][19][20]25 Low-grade urothelial carcinoma with focal squamous differentiation has a higher recurrence rate than pure low-grade urothelial carcinoma. 23,26 Tumours with any identifiable urothelial element are classified as urothelial carcinoma with squamous differentiation, and an estimate of the percentage of squamous component should be provided in the report.…”

Section: U R O T H E L I a L C A R C I N O M A W I T H S Q U A M O U mentioning

confidence: 99%

“…In general, variant urothelial carcinoma is considered an aggressive feature as it worsens overall survival due to a higher rate of upstaging after surgery. [13][14][15][16][17][18][19][20]25,37,38,56,67,[109][110][111][112] Gofrit et al suggest that a patient with variant bladder cancer treated with intravesical immunotherapy has a 27% chance of dying from this disease within 5 years when compared to a 7.5% chance for a patient with conventional high-grade urothelial carcinoma. 20 Cohen et al recommend considering aggressive treatment for bladder cancer with variant histology when identified.…”

Section: Variant Urothelial Carcinoma In Clinical Practicementioning

confidence: 99%

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Variants and new entities of bladder cancer

et al. 2018

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Pathological evaluation of bladder cancer typically reveals great tumour heterogeneity, and therefore the common observation of urothelial carcinoma exhibiting a wide variety of histopathological patterns is not surprising. Some of these patterns are so distinctive that they have been recognised as specific variants of urothelial carcinoma. Classifications have recently been revised in the 2016 World Health Organisation (WHO) classification of tumours of the urinary system and male genital organs. The current WHO classifications clarify terminological issues and provide better definition criteria, but also incorporate some new entities. Many of these variants have important prognostic or therapeutic implications worth knowing by the urologist and oncologist, but also represent diagnostic challenges in daily pathology practice. This review will discuss the features of variants of urothelial carcinoma in the context of our current clinical practice. Histological variations and new entities of bladder cancer not included in the current WHO classification of urothelial tumours will be briefly discussed.

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Section: Urothelial Carcinoma With Divergent Differentiationmentioning

confidence: 99%

Section: Variant Urothelial Carcinoma In Clinical Practicementioning

confidence: 99%

Section: U R O T H E L I a L C A R C I N O M A W I T H S Q U A M O U mentioning

confidence: 99%

Section: Variant Urothelial Carcinoma In Clinical Practicementioning

confidence: 99%

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Variants and new entities of bladder cancer

et al. 2018

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“…On the other hand, Amin, 2013 [1] record of squamous cell differentiation in only 6.2%. While, Liu et al, 2017 [36] detected it in 19.3% of radical cystectomy cases for UC in Roswell Park Cancer Institute. This variation can be related to indefinite criteria for squamous differentiation in UC and different geographical distribution with variable factors affecting metaplasia, also cystectomy specimen could vary from biopsy.…”

Section: Discussionmentioning

confidence: 96%

Keratin 17 Immunohisto chemical Expression and Prognostic Value in Bladder Urothelial Carcinoma

Bebars¹,

Ghanam

Said

2019

The Medical Journal of Cairo University

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Background: Bladder cancer is the 2 nd most common site of cancer in Egyptian males (12.7%), compared to other countries, the incidence and mortality rates are high. The ratio of Squamous Cell Carcinoma (SCC) & Urothelial Carcinoma (UC) types showed a shift towards UC. Keratin 17 (K17) is an oncoprotein that has a role in tumor progression. K17 is overexpressed in SCC, triple negative breast cancer & others. Aim of Study: This study aimed to explore the expression of K17 protein in UC in bladder biopsies of Egyptian cases. Also, to correlate K17 expression with the available clinicopathological data of the studied cases. Patients and Methods: This study was carried out on 60 cases of Egyptian bladder UC. Sections of the collected paraffin blocks were performed and applied for Immunohistochemical staining with K17, mouse monoclonal anti-human K17 antibody. Positive K17 cases assessed for intensity staining and distribution of positive stained cells into (mild, moderate and strong) staining results. Results: K17 showed high expression in UC Egyptian patients biopsies (56.7%), strong intensity was found in more than half of positive cases while it was negative in normal urothelium. K17 is more expressed in papillary UC pattern and more related to bad prognosis features as high grade and muscle invasion. Significant association was detected between positive K17 and squamous differentiation in UC cases. All moderate intensity (100%) and majority of strong staining (77.8%) were of papillary UC (p<0.001). In addition, significant association was found between moderate & strong K17 intensity and negative schistosomiasis ovae cases (p=0.003). Conclusion: Our study calls for considering high expression of K17 in UC especially papillary pattern, high grade & muscle invasion. This study also sheds light on significant association of K17 in UC with squamous differentiation & absence of Schistosomiasis.

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Detection of HPV infection in urothelial carcinoma using RNAscope: Clinicopathological characterization

et al. 2021

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Background Human papillomavirus (HPV) is a well‐established mucosotropic carcinogen, but its impact on urothelial neoplasm is unclear. We aimed to clarify the clinical and pathological features of HPV‐related urothelial carcinoma (UC). Methods Tissue samples of 228 cases of UC were obtained from the bladder, upper and lower urinary tract, and metastatic sites to construct a tissue microarray. The samples were analyzed for the presence of HPV by a highly sensitive and specific mRNA in situ hybridization (RISH) technique (RNAscope) with a probe that can detect 18 varieties of high‐risk HPV. We also conducted immunohistochemistry (IHC) for a major HPV capsid antibody and DNA‐PCR. Results The HPV detection rates varied among the methods; probably due to low HPV copy numbers in UC tissues and the insufficient specificity and sensitivity of the IHC and PCR assays. The RISH method had the highest accuracy and identified HPV infection in 12 (5.2%) of the cases. The histopathological analysis of the HPV‐positive UC showed six cases of usual type UC, five cases of UC with squamous differentiation (UC_SqD), and one case of micropapillary UC. The HPV detection rate was six‐fold higher in the cases of UC_SqD than in the other variants of UC (odds ratio [OR] =8.9, p = 0.002). In addition, HPV infection showed a significant association with tumor grade (OR =9.8, p = 0.03) and stage (OR =4.7, p = 0.03) of UC. Moreover, the metastatic rate was higher in HPV‐positive than in negative UC (OR =3.4). Conclusion These data indicate that although the incidence of HPV infection in UC is low, it is significantly associated with squamous differentiation and poor prognosis. Furthermore, our observations show that RNAscope is an ideal method for HPV detection in UC compared with the other standard approaches such as IHC and PCR assays.

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Urothelial Carcinoma with Squamous Differentiation is Associated with High Tumor Stage and Pelvic Lymph-Node Metastasis

Cited by 44 publications

References 26 publications

Variants and new entities of bladder cancer

Variants and new entities of bladder cancer

Keratin 17 Immunohisto chemical Expression and Prognostic Value in Bladder Urothelial Carcinoma

Detection of HPV infection in urothelial carcinoma using RNAscope: Clinicopathological characterization

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