Urothelial carcinoma of bladder having rhabdoid differentiation with isolated scapular metastasis

Pasricha, Sunil; Hafiz, Ather; Gandhi, Jatin; Mehta, Anurag

doi:10.4103/0973-1482.92008

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Although our patient had microscopic hematuria, his chief complaint was that he was unable to urinate. Other studies had similar findings as ours of CK 7+, p63+ and CK20+ in immunohistochemistry staining of signet ring cells [10,14] . Even though our patient had innumerable small bone metastases, he did not have any bone symptoms.…”

Section: Discussionsupporting

confidence: 89%

“…To our knowledge, this is the first case in the literature reporting the use of NaF18-PET/CT bone scan in the diagnostic staging of signet ring cell type bladder carcinoma. According to our literature search, this is the third case of bladder cancer metastasizing to the right acromion (see Figure 1), which is very rare [14,15] , although in our case, it was spread throughout the entire axial skeleton. Bladder cancers are more prevalent in whites than in blacks [3] and we report a very rare type of bladder cancer in a black man.…”

Section: Discussionmentioning

confidence: 59%

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Widespread osseous metastasis of signet ring type bladder cancer detected by NaF18-PET/CT bone scan

Win

Aparici

2012

JBGC

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We present a case of a 70 year old black male with innumerable small osseous metastases which were not visible on FDG-PET/CT or CT and were only detected by NaF18-PET/CT bone scan. To our knowledge, this is the first case in the literature reporting the use of NaF18-PET/CT bone scan in the initial staging of signet ring cell bladder carcinoma. Metastatic bone disease was widely spread throughout the skeleton. Some bladder cancers are detected in late stages and have occult distant metastases. Signet ring type adenocarcinomas of the bladder are very rare and they have a very aggressive nature. Proper staging can save the patients from undue surgical procedures. NaF-PET/CT may be a necessary tool in the diagnostic staging of aggressive bladder cancers.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 59%

Widespread osseous metastasis of signet ring type bladder cancer detected by NaF18-PET/CT bone scan

Win

Aparici

2012

JBGC

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“…However, these are examples of local and distant metastatic invasion, not primary tumor of bone. There are also cases of extrarenal extracranial rhabdoid tumor (EERT) with diffuse presentations involving bone at birth [19], as well as case reports of bone metastases in older adults from EERT locations such as bladder [20], pancreas [21], and colon [22], again, though these are examples of local or distant metastatic invasion, not primary tumors of bone origin. With the exception of our above described case, there has been no description of primary osteosarcoma of bone with rhabdoid features in the literature.…”

Section: Discussionmentioning

confidence: 99%

Primary Osteosarcoma of the Bone with Rhabdoid Features: A Rare, Previously Undescribed Primary Malignant Tumor of Bone

Seiter

Maaieh

Rosenberg

et al. 2016

Case Reports in Surgery

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Primary osteosarcoma of the bone with rhabdoid features is a rare malignant tumor of bone, not previously described in the literature. Here we report a 69-year-old female who originally presented with a right femur pathologic fracture. Radiographs of the injury showed an aggressive-appearing lesion of the distal femur. Initial biopsy was done, which was not diagnostic; additional advanced imaging studies were performed, which failed to show any other site within the body with detectable disease process. Accordingly, the patient underwent radical resection of the distal femur and reconstruction with endoprosthesis. Histopathology obtained from the operative specimen showed osteosarcoma with rhabdoid features. Two months after surgery, the patient is symptom-free and doing well; she is currently pending adjuvant chemotherapy. Although rhabdoid features have been described in extraskeletal osteosarcoma, this appears to be the first mention of osteosarcoma of bone with rhabdoid features in the literature.

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Loss of expression of the SWI/SNF complex is a frequent event in undifferentiated/dedifferentiated urothelial carcinoma of the urinary tract

et al. 2016

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Loss of the SWI/SNF chromatin remodeling complex has been recently implicated in the pathogenesis of dedifferentiated carcinomas from different organs, but its possible role in undifferentiated urothelial carcinoma (UC) has not been studied to date. In this study, we analyzed by immunohistochemistry 14 undifferentiated UCs (11 from bladder and 3 from renal pelvis) with a nondescript anaplastic or rhabdoid morphology, using commercially available antibodies against the SWI/SNF components SMARCB1 (INI1), SMARCA2, SMARCA4, SMARCC1, SMARCC2, and ARID1A. Patients were eight females and six males aged 40 to 84 years (median, 65). All tumors were muscle-invasive (9 were T3-4). A conventional UC component was seen in eight cases and varied from in situ to papillary. The undifferentiated component comprised 60-100 % of the tumors. Histologically, most tumors showed diffuse dyscohesive or pseudoalveolar growth of variably sized cells with frequent rhabdoid features. Transition from conventional to undifferentiated UC was abrupt, except in one case. The undifferentiated component almost always expressed pan-cytokeratin AE1/AE3 (13/14) and variably vimentin (8/14) and GATA3 (9/14). Complete loss of at least one SWI/SNF subunit limited to the undifferentiated component was detected in 10/14 cases (71 %). SMARCA2 was most frequently lost (six) followed by ARID1A (four), SMARCB1/INI1 (two), SMARCA4 (one), and SMARCC1 (one). This is the first study exploring SWI/SNF expression in undifferentiated UC of the urinary tract. Our results are in line with recent studies reporting involvement of the SWI/SNF complex in the dedifferentiation process of a variety of epithelial neoplasms in different organs, including the urinary tract, and association with aggressive clinical course.

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Urothelial carcinoma of bladder having rhabdoid differentiation with isolated scapular metastasis

Cited by 4 publications

References 6 publications

Widespread osseous metastasis of signet ring type bladder cancer detected by NaF18-PET/CT bone scan

Widespread osseous metastasis of signet ring type bladder cancer detected by NaF18-PET/CT bone scan

Primary Osteosarcoma of the Bone with Rhabdoid Features: A Rare, Previously Undescribed Primary Malignant Tumor of Bone

Loss of expression of the SWI/SNF complex is a frequent event in undifferentiated/dedifferentiated urothelial carcinoma of the urinary tract

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