Urothelial cancers after renal transplantation

Cox, Jerry; Colli, Janet

doi:10.1007/s11255-011-9907-z

Cited by 30 publications

(27 citation statements)

References 15 publications

(27 reference statements)

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“…Mean age of patients in this cohort was 55 (36-73) years, and the patient with upper tract cancer was 67 years old. [6] Our patient was 30 years old at the time of diagnosis which further verifies the early onset of the disease compared with the the expected age of >70 years for upper tract urothelial carcinoma.…”

Section: Transplantationsupporting

confidence: 70%

“…Patients developing urothelial cancer following renal transplantation were found to have higher stage of disease [6] and our patient was also diagnosed with pT3 disease following nephroureterectomy. These findings suggest the early onset and aggressive nature of the disease in this specific patient population.…”

Section: Transplantationmentioning

confidence: 59%

“…Renal cell carcinoma developing in the native kidney is the most common genitourinary malignancy after renal transplantation, however rare cases of de novo urothelial carcinoma in the pelvis or ureter of allograft kidney have also been reported. [3][4][5][6][7][8] Here, we present a renal allograft recipient who developed urothelial carcinoma in the upper ureter of allograft kidney.…”

Section: Introductionmentioning

confidence: 99%

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Urothelial carcinoma of the allograft kidney developed in a renal transplant patient

Gökçe

Kocaay

Aktürk

et al. 2016

Turkish Journal of Urology

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Section: Transplantationsupporting

confidence: 70%

Section: Transplantationmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

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Urothelial carcinoma of the allograft kidney developed in a renal transplant patient

Gökçe

Kocaay

Aktürk

et al. 2016

Turkish Journal of Urology

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“…Painless gross hematuria is usually the most common symptom, as occurred in Li et al [4] and Cox and Colli [9] studies. That is the main reason why some authors recommend a quick and thorough evaluation of gross hematuria [9, 15]. Other possibilities such as incidental finding, microhematuria, hydronephrosis, or irritative syndrome can be the first manifestation of a TCC.…”

Section: Discussionmentioning

confidence: 98%

“…Moreover, TCC in RTRs is regarded as being more aggressive, poorly differentiated, rapidly progressive, and more often fatal than in normal population. It is not surprising to find in these patients a higher incidence of locally advanced disease or metastatic presentation, as well as a significantly lower age at diagnosis [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Hevia

Gómez

Álvarez

et al. 2013

Case Reports in Transplantation

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Purpose. Transitional cell carcinoma (TCC) affecting the graft after renal transplantation is a very infrequent way of presentation of this tumor. Our aim is to present our single institution experience with 2 cases, as well as to perform a review of the literature about this tumor after the transplant. Materials and Methods. TCC of the graft developed in 2 of 1365 patients from 1977 to 2010, both cases in women. Data were analyzed for incidence, clinical presentation, treatment, and outcomes. Results. Both cases occurred in 2 mid-age women and resulted to be high grade and locally advanced TCCs, representing an incidence of 0,14% (2/1365). Clinical presentation was urinary obstruction for the first case and incidental ultrasound finding for the second. Preoperative staging was made with CT, cytology, pyelography, ureterorenoscopy, and biopsy. Treatment performed was nephroureterectomy of the graft with bladder cuff and regional lymphadenectomy. Pathological examination showed in both cases a locally advanced and high grade urothelial carcinoma of the pelvis allograft. After 24 and 14 months of followup, both patients are disease free. Conclusions. TCC of the kidney graft is an infrequent tumor that has only been reported in a few cases in the literature. It usually appears at a lower age, more often locally advanced, and with poor differentiation. A multidisciplinary approach to treatment should be required in these cases.

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Complete response to pembrolizumab for metastatic urothelial carcinoma in the renal pelvis of allograft kidney

et al. 2022

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Introduction We present a case of urothelial carcinoma in a renal allograft successfully treated with pembrolizumab. Case presentation A 39‐year‐old woman presented with nausea and anorexia 9 years after a renal transplantation. Positron emission tomography revealed a neoplasm of the renal pelvis of the allograft and multiple lymph nodes with peritoneal metastasis. A diagnosis of a non‐muscle‐invasive bladder tumor with peritoneal dissemination and jejunal metastasis of urothelial carcinoma was made. After five cycles of gemcitabine and carboplatin, the tumor progressed and pembrolizumab was administered. One week after the first dose, the allograft was rejected, necessitating arterial embolization. After the second cycle, the patient developed Stevens‐Johnson syndrome. After discontinuing pembrolizumab, positron emission tomography revealed no increased tumor activity. A complete response was achieved for 21 months without additional treatment. Conclusion Pembrolizumab was effective in treating urothelial carcinoma of the renal allograft; however, allograft rejection and loss should be considered.

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Urothelial cancers after renal transplantation

Abstract: Patients are at an elevated risk of urothelial cancers after renal transplantation probably from immune suppression.

Cited by 30 publications

References 15 publications

Urothelial carcinoma of the allograft kidney developed in a renal transplant patient

Urothelial carcinoma of the allograft kidney developed in a renal transplant patient

Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Complete response to pembrolizumab for metastatic urothelial carcinoma in the renal pelvis of allograft kidney

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