Urotensin II: Molecular Mechanisms of Biological Activity

Svistunov, Andrey; Tarasov, Vadim V.; Шахмарданова, С А; Sologova, Susanna S.; Bagaturiya, Ekaterina T; Chubarev, Vladimir N.; Galenko-Yaroshevsky, P. A.; Ávila-Rodriguez, Marco; Barreto, George E.; Aliev, Gjumrakch

doi:10.2174/1389203718666170829162335

Cited by 13 publications

(7 citation statements)

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“…It was shown that serum UII levels are elevated in conditions such as heart failure, renal failure, liver disease and diabetes [ 31 ]. According to the review by Svistunov et al, UII is involved in the pathophysiology of many stressful and adaptive reactions and in the development of cardiovascular pathologies [ 32 ]. It also appears that its role in biomedicine is not completely clear as a recent animal study showed that the deletion of the UTR in knockout mice does not affect basal hemodynamics in comparison to wild-type mice [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea

et al. 2023

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Obstructive sleep apnea (OSA) has become major public concern and is continuously investigated in new aspects of pathophysiology and management. Urotensin II (UII) is a powerful vasoconstrictor with a role in cardiovascular diseases. The main goal of this study was to evaluate serum UII levels in OSA patients and matched controls. A total of 89 OSA patients and 89 controls were consecutively enrolled. A medical history review and physical examination of the participants was conducted, with polysomnography performed in the investigated group. UII levels and other biochemical parameters were assessed according to the standard laboratory protocols. The median AHI in the OSA group was 39.0 (31.4–55.2) events/h, and they had higher levels of hsCRP when compared to control group (2.87 ± 0.71 vs. 1.52 ± 0.68 mg/L; p < 0.001). Additionally, serum UII levels were significantly higher in the OSA group (3.41 ± 1.72 vs. 2.18 ± 1.36 ng/mL; p < 0.001), while positive correlation was found between UII levels and hsCRP (r = 0.450; p < 0.001) and systolic blood pressure (SPB) (r = 0.317; p < 0.001). Finally, multiple regression analysis showed significant association of UII levels with AHI (0.017 ± 0.006, p = 0.013), SBP (0.052 ± 0.008, p < 0.001) and hsCRP (0.538 ± 0.164, p = 0.001). As UII levels were associated with blood pressure and markers of inflammation and OSA severity, it might play an important role in the complex pathophysiology of OSA and its cardiometabolic complications.

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Section: Discussionmentioning

confidence: 99%

Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea

et al. 2023

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“…U-II is a peptide ligand that acts as a potent vasoconstrictor, which was originally discovered four decades ago. The vasoconstriction activity of U-II is 10-fold more potent than that of endothelin-1[ 6 ]. Most studies of U-II have been conducted to understand its role in the development of cardiovascular diseases[ 7 ].…”

Section: To the Editormentioning

confidence: 99%

Urotensin II level is elevated in inflammatory bowel disease patients

Zhang¹,

Chen²

2022

WJG

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It was reported that the urotensin II (U-II) level in inflammatory bowel disease (IBD) patients are significantly higher than in controls. To provide future guidance for the management of cardiovascular risk factors in IBD patients, the sample size of the current study appears to be limited, and more clinical samples to compare U-II levels in IBD patients and controls are needed. This will clarify the possible roles of inflammation factors and related signaling pathways (like EPK1/2, NF-κB and Rho/ROCK) in the pathophysiology of IBD. Therefore, large multicenter studies should be done to confirm the findings and underlying mechanisms in the future.

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“…A major cellular homeostasis component, urotensin II (UII) contributes to the development of both acute and chronic diseases, inflammation, liver cirrhosis, and other conditions (138). It has been determined to affect angiogenesis and mitogenesis, using its receptor (UII-R) to exert a potent angiogenic effect in vivo as well as in vitro (139).…”

Section: The Effect Of Urotensin II (Uii) In the Common Types Of Cancermentioning

confidence: 99%

The Effect of Local Renin Angiotensin System in the Common Types of Cancer

et al. 2021

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The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body’s tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer.

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Urotensin II: Molecular Mechanisms of Biological Activity

Cited by 13 publications

References 0 publications

Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea

Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea

Urotensin II level is elevated in inflammatory bowel disease patients

The Effect of Local Renin Angiotensin System in the Common Types of Cancer

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