Urological tumours in Germany. Basic data on 56,013 cases from hospital cancer registries

Abstract

Since 1985 a special work group involved in the coordination of hospital cancer registries in Germany (AKKK) has been collecting, storing and analysing data on tumour patients, received from cancer centres, oncological departments and specialised practices. The documentation of tumour patients is based, among other things, on information concerning localisation, histological findings and tumour spread. The data are stored in a central database administered by the work group. At present it contains data on approximately 500,000 oncological patients. In the period from 1987 to 1992, 56,013 initial entries were made concerning patients with urological tumours. Of these cases, tumours of the kidney (n = 11,424) constituted 20.4%. In 94.6% of the cases, histological investigation revealed a renal cell carcinoma-pT1: 5.8%; pT2: 53.6%, pT3: 37.2% and pT4: 3.4%. Tumours of the urinary bladder (n = 16,246) constituted 29.0% of all urological tumours. In 93.8% of the cases a transitional cell carcinoma was detected-pTis: 1.0%; pTa: 36.9%; pT1: 29.6%; pT2: 16.9%; pT3: 11.4%; pT4: 4.4%. Transitional cell carcinomas of the ureter or of the collecting system (n = 1,846) constituted 3.3% of the cases. The proportion of testicular tumours (n = 6,594) amounted to 11.8%; 53.6% of these germ-cell tumours (n = 6,281) were seminomas and 46.6% were non-seminomas. In all, 66.3% of the cases were lymph-node negative. Tumours of the prostate (n = 19,903) constituted 35.5% of the cases. In the period from 1987 to 1992, the proportion of lymph-node-positive prostate carcinomas decreased from 39.8% to 16.2%. The detailed analysis of these data shows how the hospital cancer registries can support the discussion regarding diagnosis and therapy of urological tumours.

The T393C Polymorphism of the Gαs Gene (GNAS1) Is a Novel Prognostic Marker in Bladder Cancer

“…Men were affected three times more often than women, which is compatible with data from the literature (1,28,30), but neither gender nor smoking habits were related to genotypes. Age at primary diagnosis was slightly higher in TT genotypes (65.1 years) compared with CC genotypes (61.4 years) with TC genotypes showing intermediate values (63.1 years, P = 0.059 ANOVA).…”

“…There were no statistically significant differences regarding demographic characteristics between both groups, indicating that the case group is representative for the whole group. Mean age at diagnosis in our sample was 62.9 years, which is only 3.5 years younger than that described in two German epidemiologic studies surveying over 3,000 and 16,000 patients, respectively (27,28). Grading and staging was higher in our study population compared with these latter studies in which 38.9% to 54.7% were pT a , 14.9% to 25.0% pT 1 , 15.6% to 20.0% pT 2 , 8% to 10% pT 3 , and 5.0% to 6.9% pT 4 tumors (27,28).…”

“…The question remains to be answered to what extent our sample is representative for patients with bladder cancer in Germany. According to available epidemiologic surveys, most cases (f70%) are classified as superficial cancers at the time of first detection (28,29). In contrast, our sample showed a significant enrichment of patients with higher staging and grading (see Table 1).…”

Operative Therapy in Disease Progression and Local Recurrence of Renal Cell Carcinoma

“…The most frequently affected organ is the lung (38%), followed by the skeletal system (26.0%), the liver (9.6%) and the brain (3.9%) [1]. In autopsy studies from older series, the incidence of metastasis is much higher -as much as 36% in some cases [2,3].…”

Plasma Levels of Cellular Fibronectin in Patients with Localized and Metastatic Renal Cell Carcinoma

“…Hegele/Heidenreich/Kropf/von Knobloch/ Varga/Hofmann/Olbert of those with clinically localized disease will progress despite radical nephrectomy [7,8]. In advanced disease, the efficacy of available therapies (i.e.…”