Urologic and male genital manifestations of granulomatosis with polyangiitis

Alba, Marco A.; Moreno‐Palacios, Jorge; Beça, Sara; Cid, María C.

doi:10.1016/j.autrev.2015.05.012

Cited by 44 publications

(47 citation statements)

References 82 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Urogenital manifestations are present in <1% of cases of GPA, with prostatitis being most common 4. Although isolated cases have been described, urinary symptoms are typically accompanied by other signs of systemic involvement, such as sino-pulmonary symptoms 4. While our case initially presented with isolated dysuria, he did later develop rhinorrhoea, sinus congestion and sensorineural hearing loss.…”

Section: Discussionmentioning

confidence: 67%

“…This may cause a significant delay between presentation and diagnosis due to the complexity of the condition. Urogenital manifestations are present in <1% of cases of GPA, with prostatitis being most common 4. Although isolated cases have been described, urinary symptoms are typically accompanied by other signs of systemic involvement, such as sino-pulmonary symptoms 4.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone

et al. 2018

View full text Add to dashboard Cite

A previously healthy 21-year-old man presented with an 8-month history of weight loss, lethargy and dysuria unresponsive to empiric antibiotics and paraurethral drainage of a prostatic abscess. Urinalysis showed pyuria, but cultures failed to grow any organisms. Additionally, he developed new onset sensorineural hearing loss. CT of the chest showed two right-sided cavitary lesions. CT of the abdomen and pelvis demonstrated a prostatic abscess. A prostate biopsy demonstrated necrotising granulomatous prostatitis. A lung biopsy showed necrotising granulomatous inflammation. He was diagnosed with granulomatosis with polyangiitis (GPA). He was successfully treated with rituximab and prednisone. At 6-month follow-up, he continued to be in remission with resolution of his symptoms. This case demonstrates a rare presentation of prostatitis as the presenting symptom of GPA. As far as we know, this case is the first documented report of rituximab and prednisone as successful therapy for prostatitis secondary to GPA.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Urogenital involvement is a rare manifestation of ANCA vasculitis [2,7,11]. In our cohort, only one patient had proven urogenital involvement (granulomatous prostatitis).…”

Section: Discussionmentioning

confidence: 69%

Assessment of autonomic function in a cohort of patients with ANCA-associated vasculitis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…9 Studies of patients with GPA treated with cyclophosphamide have revealed bladder cancer rates of up to 5%. 10,11 Therefore, investigation in these patients should focus on ruling out malignancy prior to pursuing urethral GPA involvement as a cause for obstructive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Acute urinary retention secondary to urethral involvement of granulomatosis with polyangiitis

Anderson

Gottheil

Gabril

et al. 2017

CUAJ

View full text Add to dashboard Cite

Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) is a systemic necrotizing vasculitis of small-and medium-sized blood vessels, primarily affecting the upper and lower respiratory tracts, as well as the kidneys. Urogenital manifestations of GPA are exceedingly rare and usually respond well to systemic immunosuppressive therapy. Here, we present a case of a 36-yearold female presenting with acute urinary obstruction secondary to urethral GPA involvement in the immediate postpartum period. Special consideration should be given to ruling out malignancy in all patients with a history of GPA and urethral lesions, especially when there is a history of cyclophosphamide treatment.

show abstract

Urologic and male genital manifestations of granulomatosis with polyangiitis

Cited by 44 publications

References 82 publications

Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone

Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone

Assessment of autonomic function in a cohort of patients with ANCA-associated vasculitis

Acute urinary retention secondary to urethral involvement of granulomatosis with polyangiitis

Contact Info

Product

Resources

About