Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Juan Ignacio Jiménez-Loygorri,
Álvaro Viedma-Poyatos,
Raquel Gómez-Sintes
et al.
Abstract:Background
Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the number of people affected is expected to almost double by 2040. The retina presents one of the highest metabolic demands in our bodies that is partially or fully fulfilled by mitochondria in the neuroretina and retinal pigment epithelium (RPE), respectively. Together with its post-mitotic status and constant photooxidative damage from incoming light, the retina r… Show more
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