Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis
Takeshi Yasuda,
Tomohisa Takagi,
Kohei Asaeda
et al.
Abstract:Maintaining the mucus layer is crucial for the innate immune system. Urolithin A (Uro A) is a gut microbiota-derived metabolite; however, its effect on mucin production as a physical barrier remains unclear. This study aimed to elucidate the protective effects of Uro A on mucin production in the colon. In vivo experiments employing wild-type mice, NF-E2-related factor 2 (Nrf2)-deficient mice, and wild-type mice treated with an aryl hydrocarbon receptor (AhR) antagonist were conducted to investigate the physiol… Show more
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