Urolithiasis in Pediatric Patients: A Single Center Study of Incidence, Clinical Presentation and Outcome

VanDervoort, Kristy; Wiesen, Jonathan; Frank, Rachel; Vento, Suzanne; Crosby, Virginia; Chandra, Manju; Trachtman, Howard

doi:10.1016/j.juro.2007.02.002

Cited by 299 publications

(235 citation statements)

References 13 publications

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“…Hematuria and uncharacteristic abdominal pain are common in only 10% to 14% of all pediatric cases (33,37,51). However, nephrolithiasis is discovered incidentally, during imaging evaluation for other reasons, and remains asymptomatic for a long time (24,33). In our region, the symptoms generally follow the same pattern.…”

Section: Clinical Presentationmentioning

confidence: 60%

“…However, we need to pay attention to some disorders such as cystic fibrosis (CF), spina bifida or inflammatory bowel disease, which may prone the patient to risk of stone recurrence or raise the possibility of stone formation such as oxalosis or Primary Hyperoxaluria (PH). This disorder has two types PH-1 and PH-2 (7,(23)(24)(25). Tubular disorders such as cystinuria increased the risk of stone formation, which accounted for 3% of renal stones (26).…”

Section: Risk Factors and Causes Of Nephrolithiasismentioning

confidence: 99%

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Pediatric Nephrolithiasis: Trend, Evaluation and Management: A Systematic Review

Moudi¹,

Ghaffari²,

Moradi

2016

J Pediatr Rev

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Context: Pediatric nephrolithiasis is a noticeable cause of morbidity among children. Although, nephrolithiasis is a common disease in adults, its incidence has had a rising trend in children.Objectives: Here in, we reviewed the current state regarding evaluation and management of children with nephrolithiasis in the last decade. Data Sources: The current literature regarding incidence and trend, along with diagnostic evaluation and management of children aged less than 18 years old with nephrolithiasis was searched on MEDLINE and Google scholar from January 2005 to March 2016. Study Selection and Data Extraction:The search terms included, "kidney stone OR nephrolithiasis OR urolithiasis and Pediatric OR children". English language and human studies were included. Expert opinions, editorials and case reports were excluded. Consequently, the authors independently reviewed the abstracts and the papers, which matched the inclusion criteria.Results: From a total of 1050 studies identified through the database search, 71 articles were selected for the review. According to the results of this review, pediatric nephrolithiasis has an increasing rate worldwide. Recent studies in this regard indicated that the number of girls with nephrolithiasis has increased. The change of life style, diet, obesity and metabolic syndrome and popular imaging study along with referral of the patients to pediatric centers could be contributed to this trend. Conclusions:Evaluation of patients, particularly young children, includes metabolic assessment. Stone analysis and 24-urine collection analysis are very helpful for determining underlying diseases. Medical as well as surgical approaches are used to prevent kidney injuries.Keywords: Nephrolithiasis, Children, Incidence, Management ContextOver the past decades, the prevalence of pediatric nephrolithiasis has increased by 70% in adults and has become the third top urinary tract disease, and the gender gap between males and females is narrowing in many countries, as about 10% and 5% of males and females, respectively, complain of this condition during their life (1-3). Sas et al. (4) reported in their study that during the last couple of decades, the incidence of pediatric nephrolithiasis has increased by approximately 6 to 10% annually and has actually reached 50 per 100000 in adolescents.This situation may cause some complications and has subsequent health care and medical costs. Pearle et al. (5) estimated that more than two billion dollars is incurred annually for nephrolithiasis in the United States. This condition causes further chronic conditions requiring health care services in pediatric medicine. Moreover, recent studies revealed that this disorder has a genderrelated distribution in this context by more inclination toward nephrolithiasis. In addition, race and geographic location may play a role in nephrolithiasis development. African countries have low prevalence and the Middle East, Pakistan and India have higher incidence of urolithiasis (6, 7). ObjectivesThis review...

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Section: Clinical Presentationmentioning

confidence: 60%

Section: Risk Factors and Causes Of Nephrolithiasismentioning

confidence: 99%

Pediatric Nephrolithiasis: Trend, Evaluation and Management: A Systematic Review

Moudi¹,

Ghaffari²,

Moradi

2016

J Pediatr Rev

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“…Hiperkalsiüri ve hipositratüri en sık bildirilen metabolik anomalilerdir. 3,14 Çocuklarda taşların %70-80'i kalsiyum oksalat, %5-10'u ürik asit, %5-10'u strüvit (magnezyum amonyum fosfat), %1-5'i sistin taşlarıdır. [19][20][21][22][23][24] Nadiren ksantin ve 2,8-dihidroksiadenin taşları ile karşılaşılmaktadır.…”

Section: Patofi̇zyoloji̇unclassified

“…2 Ekonomik olarak gelişmiş ülkelerde, çocuklarda üroliti-yaz sık rastlanmayan bir durum olmakla birlikte, son dekadda insidansının 5 kat arttığı bildirilmiş-tir. 3 Bu artışın nedeni konusunda ileri sürülen faktörler; yemek yeme alışkanlığındaki değişiklik (yüksek oranda tuz, fruktoz ve hayvansal protein ama düşük oranda kalsiyum içeren "fast-food" tarzı yiyecekler), sedanter yaşam formunda artış, obezitede artış, küresel ısınmaya yol açan iklim değişik-likleri ve antibiyotik kullanımında artıştır. 4,5 Ürolitiyazin hangi cinsiyette daha fazla olduğuna dair çalışma sonuçları değişkenlik göstermek-tedir.…”

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Urolithiasis in Childhood: Review

Zeybek¹,

Orman²

2017

Turkiye Klinikleri J Pediatr

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“…The prevalence of urolithiasis is rising, both in countries in which stone disease is endemic, such as Turkey, and also in non-endemic ones, [1][2][3][4][5] either because of increasing awareness or because of the greater use of radiologic diagnostic techniques. Factors leading to urolithiasis include metabolic abnormalities, genetics, nutrition, environment, and specific medicines.…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis

et al. 2016

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Polymorphisms in the vitamin D receptor (VDR) gene have recently been reported to be associated with urinary calculi in pediatric and adult cases, but no studies have looked at the youngest period of life. The purpose of this study was to investigate the role of VDR gene polymorphisms in infantile urolithiasis in a Turkish population. We compared a study group of 104 infants (55 girls and 49 boys, mean age 6.94 ± 3.81 months) with a control group of 96 infants (51 girls and 45 boys, mean age 7.51 ± 3.23) to evaluate their demographics and metabolic risk factors. PCR-based restriction analysis of the polymorphisms on the VDR gene (BsmI and TaqI) showed statistically significant differences between study and control groups (p ¼ 0.001 and 0.043, respectively). In addition, the prevalence of the BsmI genotype was significantly different between the hypercalciuric and normocalciuric stone formers (p ¼ 0.007). Allelic frequencies were similar between the urolithiasis and control groups (p40.05). The B allele of BsmI and the A allele of ApaI were more prevalent in the hypercalciuric stone formers than in the normocalciuric stone formers (p ¼ 0.018 vs.0.036, respectively). These results suggest that the BsmI and TaqI VDR genotypes could be candidate genes leading to infantile urolithiasis. ARTICLE HISTORY

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Urolithiasis in Pediatric Patients: A Single Center Study of Incidence, Clinical Presentation and Outcome

Cited by 299 publications

References 13 publications

Pediatric Nephrolithiasis: Trend, Evaluation and Management: A Systematic Review

Pediatric Nephrolithiasis: Trend, Evaluation and Management: A Systematic Review

Urolithiasis in Childhood: Review

The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis

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