Urolithiasis and Its Herbal Remedies

Dhole, Archana R.; Yeligar, Veerendra C.

doi:10.32628/ijsrst1840116

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…However, on days 21 and 28, the BUN, serum creatinine, urea, uric acid levels, and LDH level were significantly (p≤0.0001) decreased in curative regimen groups (III and IV) when compared to EG-induced Group I animals (Tables 3 and 4, Figs. [7][8][9][10][11]. increased in Groups I, II, III, and IV animals.…”

Section: Resultsmentioning

confidence: 99%

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Antiurolithiatic Activity of Ethanolic Extract of Eichhornia Crassipes (Mart.) Solms Whole Plant on Ethylene Glycol-Induced Urolithiasis in Wistar Rats

Indumathy

2022

Asian J Pharm Clin Res

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Objective: In India Indigenous system of medicine, the plant Eichhornia crassipes (Mart.) Solms is claimed to be useful for different ailments. The purpose of this study is to investigate the significant activity of the ethanolic extract of E. crassipes (Mart.) Solms whole plant in the treatment of renal stone by ethylene glycol (EG)-induced urolithiasis in Wistar rats. Methods: Wistar rat will be divided into four groups. All the animals received EG 0.75%v/v by orally for 28 days. Group I was received 0.75%v/v EG for 28 days. Groups II, III, and IV were received cystone, ethanolic extract of E. crassipes (Mart.) Solms (200 mg/kg, and 400 mg/kg), respectively, administered orally from 15th to 28th day for curative regimen. Animals were housed in metabolic cages and collect the 24 h urine samples and serum samples on the 7th, 14th, 21th, and 28th day of the experiments. Under the microscopical study to observe the crystals in urine sample. The biochemical parameters monitored in the present study are calcium, oxalate, magnesium, phosphorus, urea, creatinine, uric acid, blood urea nitrogen (BUN), and lactate dehydrogenase (LDH) in urine and serum samples. Results: The EG feeding resulted in elevated renal excretion of calcium, phosphate, oxalate, and decreased renal excretion of magnesium as well-elevated serum BUN, creatinine, uric acid, urea, LDH levels, and decreased the urine pH and urine volume. Treatment of the ethanolic extract of E. crassipes (Mart.) Solms significantly reduced the elevated calcium, phosphate, oxalate in urine as well as BUN, creatinine, uric acid, urea, and LDH level in serum. It also restores the normal urine pH and promotes the urine output. Conclusion: Ethanolic extract of E. crassipes (Mart.) Solms exhibited significant anti-urolithiatic activity evident from urine calcium, phosphate, oxalate levels and serum BUN, creatinine, uric acid, urea and LDH levels.

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Section: Resultsmentioning

confidence: 99%

“…In India, Ayurvedic system of medicine "Pashanabheda" (Pashana = stone; Bheda = break) group of plants break up the urinary stones and increase the urine output. This information on the present trends in research on plants accredited with antiurolithiatic activity [8]. Eichhornia crassipes (Mart.)…”

Section: Introductionmentioning

confidence: 98%

Antiurolithiatic Activity of Ethanolic Extract of Eichhornia Crassipes (Mart.) Solms Whole Plant on Ethylene Glycol-Induced Urolithiasis in Wistar Rats

Indumathy

2022

Asian J Pharm Clin Res

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“…Since millennia dating back to 4000 B.C., humans have experienced the most frequent illness of the urinary tract-renal stones. 12% of the world's population is affected by this growing urological health issue [1]. Between 1% to 19.1% of people in Asia have urolithiasis.…”

Section: Introductionmentioning

confidence: 99%

“…Urolithiasis is causing a rise in other urological problems, which has been linked to a higher risk of end-stage renal failure [1]. Urinary tract stone illnesses require medical and veterinary challenges due to their multifactorial origin and high rate of recurrence.…”

Section: Introductionmentioning

confidence: 99%

A narrative review on efficacy of homoeopathic medicine Pareira brava in urolithiasis.

Pathan

Mulla

Gajendragadkar

2023

Sust. Agric. Food Env. Res.

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Urolithiasis orNephrolithiasis commonly known as renal calculi, kidney stones, or urine calculi, are terms used to describe the disease of renal stones. Since many years, mankind has been afflicted with this condition, which, if left untreated, may progress to End Stage Renal Disease (ESRD). The multiple aetiology and risk factors of renal stone disease affect about 12% of the world's population. Understanding the process of stone production is extremely difficult because there are many different types of stones, including calcium oxalate and calcium phosphate. The conventional medical system has used a variety of medications and procedures, including PCNL and ESWL, to treat urolithiasis. However, the rate of recurrence is remainshigh. Extracts from plants are now utilized to treat kidney stones. There is evidence that homoeopathic medications are employed as curative therapies as well. One of the treatments that homoeopaths usually recommend for kidney stone disease is Pareira Brava. Therefore, use of homoeopathic intervention is attempted in the current review in an effort to shed insight on the evolutionary changes in stone production technology and to lower the recurrence rate.

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Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects

Lobine

Ahmed

Aschner

et al. 2020

Drug Development Research

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Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available both to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds which holds immense potential as therapeutic for treating kidney stone. This review aims to provide an integrative description on how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various mechanisms such as antioxidant, anti‐inflammatory, diuretic, and angiotensin‐converting enzyme inhibition. Some of the pentacylic triterpenes which shows promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives in the development of pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.

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Urolithiasis and Its Herbal Remedies

Cited by 3 publications

References 12 publications

Antiurolithiatic Activity of Ethanolic Extract of Eichhornia Crassipes (Mart.) Solms Whole Plant on Ethylene Glycol-Induced Urolithiasis in Wistar Rats

Antiurolithiatic Activity of Ethanolic Extract of Eichhornia Crassipes (Mart.) Solms Whole Plant on Ethylene Glycol-Induced Urolithiasis in Wistar Rats

A narrative review on efficacy of homoeopathic medicine Pareira brava in urolithiasis.

Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects

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