Urokinase-Type Plasminogen Activator Receptor Expression in Adenoid Cystic Carcinoma of the Skull Base

Doerr, Timothy D.; Marentette, Lawrence J.; Flint, Andrew; Elner, Victor M.

doi:10.1001/archotol.129.2.215

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…16 The final study group consisted of 520 patients: 99 were enrolled in the international cohort and 421 were extracted from 15 published studies. [6][7][8][17][18][19][20][21][22][23][24][25][26][27][28] The median age of the patients was 50 years (range, 38 to 55 years). The median follow-up period was 60 months (range, 32 to 100 months).…”

Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

et al. 2013

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Objectives?To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design?Meta-analysis of the literature and data from the International ACC Study Group. Setting?University-affiliated medical center. Participants?The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures?Overall survival (OS) and disease-specific survival (DSS). Results?The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p?

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Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

et al. 2013

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“…The urokinase-type plasminogen activator receptor influences tumor invasion and metastasis by facilitating the destruction of extracellular matrices, so its expression seems to be a negative prognostic factor [72].…”

Section: (4) Cell Adhesion Proteinsmentioning

confidence: 99%

Adenoid cystic carcinoma of the head and neck – An update

et al. 2015

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“…[6][7][8][17][18][19][20][21][22][23][24][25][26][27][28] The median age of the patients was 50 years (range, 38 to 55 years). The median follow-up period was 60 months (range, 32 to 100 months).…”

mentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

et al. 2014

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Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS).Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant

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Urokinase-Type Plasminogen Activator Receptor Expression in Adenoid Cystic Carcinoma of the Skull Base

Abstract: In most patients with ACC of the skull base, uPAR was expressed. Its expression seems to be a negative prognostic factor. However, the small study sample limits our observations. Additional study of uPAR expression in ACC at other anatomic sites is required.

Cited by 9 publications

References 23 publications

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Adenoid cystic carcinoma of the head and neck – An update

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

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