“…Integrin v3 suppresses uPA/uPAR expression in ovarian cancer cells (Hapke et al, 2001) and, as noted previously, the MMP2 axis has been associated with expression of the v3 integrin and v3 is required for MMP2 activation in some cell types (Deryugina et al, 2001); Nisato et al, 2005), including PDAC (Hosotani et al, 2002). Reciprocally, the uPA/uPAR axis is linked to v5 (Yebra et al, 1995; and other integrins including 31 (Zhu et al, 2009), which is also expressed by both MIAPaCa2 and BxPC3 cells (S. Silletti, unpublished data). Importantly, the differential integrin utilization by these cells extended to the regulation of invasion as well.…”