Urodynamic Evaluation in Simultaneous Insulin-Dependent Diabetes Mellitus and End Stage Renal Disease

Menéndez, Violeta; Cofan, Frederic; Talbot-Wright, R; Ricart, M. J.; Gutiérrez, R; Carretero, P

doi:10.1016/s0022-5347(01)66074-9

Cited by 49 publications

(22 citation statements)

References 14 publications

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“…A number of clinical studies in men and women with diabetes have reported bladder instability or hypersensitivity as the most frequent finding, ranging from 39 -61% of subjects (5,7). Diminished bladder contractility or sensation has been found less often (5), and an acontractile bladder appears to be quite uncommon.…”

Section: Iabetes and Urologic Diseases Arementioning

confidence: 99%

Urologic Complications of Diabetes

et al. 2005

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Section: Iabetes and Urologic Diseases Arementioning

confidence: 99%

Urologic Complications of Diabetes

et al. 2005

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“…Such symptoms include impaired bladder sensation, impaired detrusor contractility, and increased bladder capacity leading to significant distress, limitations in daily functioning, and poor quality of life (1,3). It appears that up to 80% of patients with diabetes may eventually develop some type of bladder dysfunction (4). Unfortunately there are few systems biology studies focusing on the initiation, development, and progression of the bladder dysfunction in diabetic patients or relevant animal models.…”

mentioning

confidence: 99%

Proteomics Analysis Identifies Molecular Targets Related to Diabetes Mellitus-associated Bladder Dysfunction

Yohannes

Chang

Christ

et al. 2008

Molecular & Cellular Proteomics

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Protein expression profiles in rat bladder smooth muscle were compared between animal models of streptozotocin-induced diabetes mellitus (STZ-DM) and age-matched controls at 1 week and 2 months after induction of hyperglycemia with STZ treatment. At each time point, protein samples from four STZ-DM and four age-matched control rat bladder tissues were prepared independently and analyzed together across multiple DIGE gels using a pooled internal standard sample to quantify expression changes with statistical confidence. A total of 100 spots were determined to be significantly changing among the four experimental groups. A subsequent mass spectrometry analysis of the 100 spots identified a total of 56 unique proteins. Of the proteins identified by two-dimensional DIGE/MS, 10 exhibited significant changes 1 week after STZ-induced hyperglycemia, whereas the rest showed differential expression after 2 months. A network analysis of these proteins using MetaCore TM suggested induction of transcriptional factors that are too low to be detected by two-dimensional DIGE and identified an enriched cluster of down-regulated proteins that are involved in cell adhesion, cell shape control, and motility, including vinculin, intermediate filaments, Ppp2r1a, and extracellular matrix proteins. The proteins that were up-regulated include proteins involved in muscle contraction (e.g. Mrlcb and Ly-GDI), in glycolysis (e.g. ␣-enolase and Taldo1), in mRNA processing (e.g. heterogeneous nuclear ribonucleoprotein A2/B1), in inflammatory response (e.g. S100A9, Annexin 1, and apoA-I), and in chromosome segregation and migration (e.g. Tuba1 and Vil2). Our results suggest that the development of diabetes-related complications in this model involves the down-regulation of structural and extracellular matrix proteins in smooth muscle that are essential for normal muscle contraction and relaxation but also induces proteins that are associated with cell proliferation and inflammation that may account for some of the functional deficits known to occur in diabetic complications of bladder.

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“…Since the prevalence of voiding dysfunction in our present study is small, we cannot identify which original diseases are risk factors for voiding dysfunction after RTX. However, it is reported that 86% of patients with ESRD due to diabetic nephropathy have urodynamic abnormality 1 and urodynamic abnormalities were also observed in ESRD due to other diseases. 2,3 Further study is necessary to evaluate the impact of original diseases of ESRD for micturition function.…”

Section: Discussionmentioning

confidence: 99%

“…Actually, there is an incidence of urodynamic abnormalities in ESRD. [1][2][3] After successful RTX, urine production is immediately restored and the LUT needs to adapt to variable urine volumes after RTX. Although the adaptation of the LUT usually occurs within 6 months after RTX, 4 some studies have revealed that LUT dysfunction and LUT symptoms might persist long-term.…”

Section: Introductionmentioning

confidence: 99%

Lower urinary tract symptoms and their impact on quality of life after successful renal transplantation

et al. 2009

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Objective: To investigate lower urinary tract symptoms (LUTS) and their impact on quality of life (QOL) in patients having undergone renal transplantation (RTX). Methods: Forty-three patients (25 males and 18 females; age 20-68 years) undergoing RTX at Hokkaido University Hospital were included in this study. Median follow-up after RTX was 41 months (range 6-184). Pre-transplant dialysis had been carried out in 38 patients (median: 4.3 years, range: 1 month-31 years). All patients were assessed by uroflowmetry (UFM), postvoid residual urine volume (PVR), 24 h bladder diary, and International Prostate Symptom Score (IPSS). QOL score and King's Health Questionnaire (KHQ) were used for the assessment of LUTS-related QOL. Results: Mean fluid intake volume and urine output volume for 24 h were 2136 mL (1150-3430 mL) and 2446 mL (1336-4733 mL), respectively. Voiding dysfunction assessed by UFM and PVR was observed in 12 patients (28%) showing higher IPSS. QOL score and overall QOL in KHQ were not different between patients with and without voiding dysfunction. Although 19 (49%) had polyuria, 20 (51%) had nocturnal polyuria, which affected nocturia in IPSS as well as sleep/energy disturbances in KHQ compared with patients without nocturnal polyuria. Conclusions: Patients having RTX frequently present voiding dysfunction and nocturia basically caused by nocturnal polyuria. We should focus on LUTS in these patients to provide an appropriate management.

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Urodynamic Evaluation in Simultaneous Insulin-Dependent Diabetes Mellitus and End Stage Renal Disease

Abstract: A high frequency of vesical alterations was observed, which were modified by association of progressive vesical dysfunction and diabetes mellitus. In diabetes mellitus dialysis protects against detrusor hypocontractility but predisposes the patients to have bladder obstruction.

Cited by 49 publications

References 14 publications

Urologic Complications of Diabetes

Urologic Complications of Diabetes

Proteomics Analysis Identifies Molecular Targets Related to Diabetes Mellitus-associated Bladder Dysfunction

Lower urinary tract symptoms and their impact on quality of life after successful renal transplantation

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