Urocortin 2 modulates aspects of social behaviour in mice

Breu, J.; Touma, Chadi; Hölter, Sabine M.; Knapman, Alana; Wurst, Wolfgang; Deussing, Jan M.

doi:10.1016/j.bbr.2012.05.031

Cited by 27 publications

(38 citation statements)

References 30 publications

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“…Male, but not female, Ucn-2-knockout animals demonstrate an altered social behavior, with more-passive social interactions and reduced aggressiveness in comparison with wildtype animals. Moreover, Ucn-2 appears to modulate the aggressive behavior in male mice [66], providing additional evidence that this peptide is involved in the regulation of stress-related behaviors. Suggested mechanism involved in the cardioprotection elicited by Ucn-2-CRH-R2.…”

Section: Other Biological Effects Of Ucn-2mentioning

confidence: 82%

Urocortin 2 in cardiovascular health and disease

Adão

Santos‐Ribeiro

Rademaker

et al. 2015

Drug Discovery Today

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Section: Other Biological Effects Of Ucn-2mentioning

confidence: 82%

Urocortin 2 in cardiovascular health and disease

Adão

Santos‐Ribeiro

Rademaker

et al. 2015

Drug Discovery Today

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“…These animals are described as having normal hearing although another line of UCN 1 KO mice appeared to have disruption of hearing and an increase in anxiety-like behavior (Vetter et al, 2002) so a reduced startle response maybe due do a disruption in the startle neuronal pathway. Both UCN 2 and 3 KO animals do not show any disruption in anxiety-like behaviors, although reduced aggressiveness is seen in male UCN 2 KO's and reduced depression-like behaviors were noted in female UCN 2 KO mice (Chen et al, 2006; Deussing et al, 2010; Breu et al, 2012). However, given that both CRF and UCN's can activate CRF 2 receptors, it is not surprising that there is not a noticeable change in anxiety or consistent decrease in depression-like behaviors in the UCN 2 or 3 KO mice.…”

Section: Crf Ucn 1 2 and 3 And Crf Receptor Transgenic Animals Smentioning

confidence: 99%

Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior

Fox¹,

Lowry²

2013

Front. Neurosci.

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Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide that is involved in stress-related physiology and behavior, including control of the hypothalamic-pituitary-adrenal (HPA) axis. Members of the CRF family of neuropeptides, including urocortin 1 (UCN 1), UCN 2, and UCN 3, bind to the G protein-coupled receptors, CRF type 1 (CRF1) and CRF2 receptors. In addition, CRF binding protein (CRFBP) binds both CRF and UCN 1 and can modulate their activities. There are multiple mechanisms through which CRF-related peptides may influence emotional behavior, one of which is through altering the activity of brainstem neuromodulatory systems, including serotonergic systems. CRF and CRF-related peptides act within the dorsal raphe nucleus (DR), the major source for serotonin (5-HT) in the brain, to alter the neuronal activity of specific subsets of serotonergic neurons and to influence stress-related behavior. CRF-containing axonal fibers innervate the DR in a topographically organized manner, which may contribute to the ability of CRF to alter the activity of specific subsets of serotonergic neurons. CRF and CRF-related peptides can either increase or decrease serotonergic neuronal firing rates and serotonin release, depending on their concentrations and on the specific CRF receptor subtype(s) involved. This review aims to describe the interactions between CRF-related peptides and serotonergic systems, the consequences for stress-related behavior, and implications for vulnerability to anxiety and affective disorders.

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“…While the urocortins share 20 – 45% sequence homology with CRF, physiological functions of CRF/Ucn family peptides are not highly conserved. For example, Ucn2 and Ucn3 do not seem to directly influence stress reactivity but instead alter social behaviors in mice, suggesting that mammals have adapted these peptides for regulation of social interactions (Breu et al, 2012; Deussing et al, 2010). Figure 1 presents a schematic of the contribution of the Ucn/CRF systems to stress- and addiction related behaviors.…”

Section: Crf-related Urocortin Peptidesmentioning

confidence: 99%

Stress-Related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects

Schank

Ryabinin

Giardino

et al. 2012

Neuron

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Summary Addictive disorders are chronic, relapsing conditions that cause extensive disease burden. Genetic factors partly account for susceptibility to addiction, but environmental factors such as stressful experiences and prolonged exposure of the brain to addictive drugs promote its development. Progression to addiction involves neuroadaptations within neurocircuitry that mediates stress responses, and is influenced by several peptidergic neuromodulators. While corticotropin releasing factor is the prototypic member of this class, recent work has identified several additional stress-related neuropeptides that play an important role in regulation of drug intake and relapse, including the urocortins, nociceptin, substance P and neuropeptide S. Here, we review this emerging literature, discussing to what extent the properties of these neuromodulators are shared or distinct and considering their potential as drug targets.

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Urocortin 2 modulates aspects of social behaviour in mice

Cited by 27 publications

References 30 publications

Urocortin 2 in cardiovascular health and disease

Urocortin 2 in cardiovascular health and disease

Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior

Stress-Related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects

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