Urine saturation and promoter/inhibitor parameters and ratios in renal stone disease caused by ceftriaxone

Abstract

<jats:title>Abstract</jats:title><jats:p>During ceftriaxone treatment of subdural empyema caused by Streptococcus intermedius urinary and biliary stones were noticed. Increased levels of urinary calcium excretion were detected during ongoing treatment in comparison with 2 months check-up. There were no significant changes in the promoter/inhibitor urolithiasis parameters, oxalate, citrate, urate, cistine, glycosaminoglycans or their ratios. Urine saturation was calculated using EQUIL 2 computer programme (calcium oxalate, brushite) and it was normal. Probable trigger for the ceftriaxone/calcium hydroxy carbonate phosphate mixture of stones was a critical boost of solubility products caused by ceftriaxone treatment and phospnate urine content with a subsequent large-scale spontaneous precipitation of crystals.</jats:p>

Rational Therapy of Urinary Tract Infections in Children in Croatia

“…Th e recommended upper limit dosage of this drug is not justifi ed as the supposed increase of UTI antibacterial effi ciency has not been demonstrated. Even more, such administration signifi cantly reduces the cost/benefi t ratio and may even result in gallbladder/urinary ceftriaxone generated stones 32,33 . Fixed cost of its parenteral use is very favorable due to its once daily (24-h frequency) administration, especially if the solution for dilution of this drug has already been added.…”