Urine production and bladder diary measurements in women with type 2 diabetes mellitus and their relation to lower urinary tract symptoms and voiding dysfunction

Fayyad, Abdalla; Hill, Simon; Jones, Geraint

doi:10.1002/nau.20778

Cited by 22 publications

(13 citation statements)

References 30 publications

(43 reference statements)

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“…Among women with incontinence, both diabetic and prediabetic women were more likely to report being bothered by their incontinence and felt that incontinence affected their daily activities significantly more than nondiabetic women. This concurs with the finding by Fayyad et al [27] that number of incontinence episodes correlated with the finding of bothersome lower urinary tract symptoms (LUTS). For diabetic women, a history of foot ulcer and macroalbuminuria were associated risk factors for urgency incontinence.…”

Section: Clinical Signs and Symptoms Of Diabetic Voiding Dysfunctionsupporting

confidence: 92%

“…A variety of standardized questionnaires (eg, AUA-SI, International Consultation on Incontinence Modular Questionnaire-Female Lower Urinary Tract Symptoms [ICIQ-FLUTS], and Kings Health Questionnaire) have been consistent in showing that nocturia and number of incontinence episodes have a significant impact on QOL [26,27]. These findings were not associated with increased urine production when compared with bladder diary measurements [27]. This leads one to believe that the pathophysiology is more likely in line with OAB theories than the diuretic effect of DM.…”

Section: Clinical Signs and Symptoms Of Diabetic Voiding Dysfunctionmentioning

confidence: 99%

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Bladder Dysfunction in Patients with Diabetes

2011

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With diabetes mellitus (DM) reaching epidemic proportions, the identification of voiding dysfunction as a common and burdensome complication of this disease is critical. Research into diabetic voiding dysfunction significantly lags behind other complications of DM, such as retinopathy and nephropathy. Recent studies have revealed that DM predisposes patients to a wide range of lower urinary tract dysfunction, from the classic diabetic cystopathy of incomplete emptying to urgency incontinence. In this review, we discuss the current concepts of diabetic voiding dysfunction with a critical analysis of the available evidence.

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Section: Clinical Signs and Symptoms Of Diabetic Voiding Dysfunctionsupporting

confidence: 92%

Section: Clinical Signs and Symptoms Of Diabetic Voiding Dysfunctionmentioning

confidence: 99%

Bladder Dysfunction in Patients with Diabetes

2011

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“…Approximately 25–50% of patients do not complain about voiding problems, unless specifically asked 14. The latest cross‐sectional studies documented bothersome LUTS in ≤40% of patients with DM; bladder storage symptoms, such as urgency, urgency incontinence, or nocturia, are the most bothersome 15. Nocturia (87%) and urinary frequency (78%) were the most common symptoms in another cohort of diabetic patients, while classic symptoms of hesitancy (62%), reduced stream (52%), and incomplete emptying (45%) were less prevalent 9…”

Section: Resultsmentioning

confidence: 99%

Does diabetes mellitus‐induced bladder remodeling affect lower urinary tract function?: ICI‐RS 2011

Kirschner‐Hermanns¹,

Daneshgari²,

Vahabi³

et al. 2012

Neurourology and Urodynamics

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DM causes bladder remodelling leading to uropathy in a mulitfactorial way. Future research should focus on the effects of DM as a function of time and develop novel animal models looking at defined aspects as well as interaction of different aspects- such as oxidative stress in neurogenic, myogenic and urothelial components and the role of inflammation and hypoxia caused by vascular complications.

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“…Metabolic syndrome can be an etiologic pathway for the onset of OAB (23,24). Fayyad et al (25) documented bothersome LUTS in 40 % of the women patients with DM. In this study, OAB syndrome associated with DM was estimated to be more frequent in women subjects than men (26.7% and 14.4%, respectively).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Overactive Bladder in Type 2 Diabetes Patients with a Questionaire-Based Study

Verim¹,

Kayataş²,

Abanonu³

et al. 2016

Haseki

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Abs tractAim: Overactive bladder (OAB) is a common and well-known urologic condition. OAB occurs in both women and men. Diabetes mellitus (DM) is one of the most common metabolic disorders in the world and the prevalence of DM in adults has been increasing. Diabetic neuropathy can induce functional disease of multiple organs, including diabetic bladder dysfunction (DBD). DBD occurs commonly as a late complication and DBD is mainly characterized by poor bladder emptying, urinary retention and overflow incontinence. However, storage symptoms, as those suggestive for OAB may also affect people with DM. The aim of this study was to evaluate the prevalence of OAB in people with DM compared to healthy control subjects. Methods: We analyzed records of 212 diabetic case and 229 control subjects using the 8-item symptom bother scale of the OAB questionnaire (OAB-q) (OAB-V8). Results:Diabetic bladder overactivity was seen in 20.3% of patients with DM (n=43) and 10.5% of non-diabetic control group (n=24). The OAB prevalence in patients with DM was approximately two-fold higher than in control subjects. OAB increased with the duration of diabetes, glycosylated hemoglobin level and age. There was no significant difference in sex distribution between the groups. There is an increase in the prevalence type 2 diabetes in Turkey. DM is a common cause of reduced bladder sensation in both men and women. In this study, OAB syndrome in diabetic patients was searched. DBD is characterized by underactive (flaccid) bladder, voiding difficulty, infrequent voiding and reduced bladder sensation during urinary storage; bladder underactivity and urinary retention during urination. OAB in diabetic patients is characterized by urgency (a compelling and sudden desire to void), with or without incontinence, usually with urinary frequency and nocturia. Conclusion: OAB symptoms are more prevalent in diabetic people than in healthy people. OAB symptoms in DM may be considered as a predictor of the development of diabetic neuropathy. Thus, controlling the progression of DM might reduce the incidence of diabetic neuropathy and other late diabetic complications.

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Urine production and bladder diary measurements in women with type 2 diabetes mellitus and their relation to lower urinary tract symptoms and voiding dysfunction

Abstract: Bothersome LUTS in DM is not associated with increased urine production. Bladder capacity increased with total urine volume. Nocturia and incontinence episodes were significantly associated with bothersome LUTS.

Cited by 22 publications

References 30 publications

Bladder Dysfunction in Patients with Diabetes

Bladder Dysfunction in Patients with Diabetes

Does diabetes mellitus‐induced bladder remodeling affect lower urinary tract function?: ICI‐RS 2011

Evaluation of Overactive Bladder in Type 2 Diabetes Patients with a Questionaire-Based Study

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