Urine Liver-Type Fatty Acid-Binding Protein Predicts Graft Outcome up to 2 Years After Kidney Transplantation

Yang, Jaeseok; Choi, Hye Sook; Seo, Min Young; Lee, J. Y.; Kim, K.; Jun, Heungman; Jung, Cheol Woong; Park, K. T.; Kim, M. G.; Jo, Sang Kyung; Cho, W.; Kim, H. K.

doi:10.1016/j.transproceed.2013.11.130

Cited by 24 publications

(26 citation statements)

References 20 publications

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“…In a separate study, L‐FABP levels at 0 h, 2 days, and 6 days after kidney transplantation (KT) were measured . This study reported that a high 0‐h urinary L‐FABP level was a significant risk factor and predictor of poor long‐term graft function.…”

Section: Discussionmentioning

confidence: 99%

“…Urinary L‐FABP levels have been reported to be higher in septic shock patients with AKI than those in healthy subjects . Likewise, it has been demonstrated that urinary L‐FABP predicts graft outcome up to 2 years after kidney transplantation (KT) . A recent study assessed urinary L‐FABP levels at 0 h, 2 days, and 6 days after KT and followed patients for up to 2 years after KT.…”

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confidence: 99%

“…A recent study assessed urinary L‐FABP levels at 0 h, 2 days, and 6 days after KT and followed patients for up to 2 years after KT. It was reported that a high 0‐h L‐FABP predicted poor long‐term graft function and it was suggested that urinary L‐FABP might be a useful predictor of adverse long‐term outcomes in kidney transplant recipients . Thus, monitoring detectable L‐FABP levels in the urine can predict the occurrence and severity of various kidney diseases.…”

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confidence: 99%

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Mass spectrometric quantification of urinary human liver fatty acid binding protein in renal transplant recipients

Özcan

Akbaş

Kıraç

et al. 2016

Rapid Comm Mass Spectrometry

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Mass spectrometric quantification of urinary human liver fatty acid binding protein in renal transplant recipients

Özcan

Akbaş

Kıraç

et al. 2016

Rapid Comm Mass Spectrometry

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“…b Correlation between ischemic time and urinary L-FABP. R indicates correlation coefficient [36] disease (CKD) [53] or those who have undergone cardiac catheterization [54,55] or renal transplantation [56,57]. Clinical prospective observation studies to predict mortality in sepsis using urinary L-FABP have been conducted with both adult patients and pediatric patients (Table 3) [27,28].…”

Section: Predicting Poor Outcomesmentioning

confidence: 99%

Urinary excretion of liver-type fatty acid-binding protein reflects the severity of sepsis

et al. 2017

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Sepsis due to microbial invasion often causes multiple organ failure (MOF), including acute kidney injury (AKI), with high mortality rates in serious cases. Hence, there is an urgent need for diagnostic biomarkers that can be used to rapidly, accurately, and easily detect sepsis to identify the condition early and guide the selection of appropriate treatment. Liver-type fatty acid-binding protein (L-FABP), which localizes in renal proximal tubules, is excreted into the urine in response to oxidative stress-induced tubular injury. Because of this mechanism, L-FABP has been reported to be a useful urinary biomarker not only for renal disease but also for the severity of sepsis. Based on this concept, we developed a new L-FABP point-of-care (POC) assay kit that can be used to rapidly measure human L-FABP in the urine to further improve the usefulness of this biomarker in clinical settings. In this review, we describe the molecular mechanisms of L-FABP, its clinical usefulness, and the performance of the POC assay kit.

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“…En la actualidad son pocos los biomarcadores que existen para la evaluación de la lesión renal aguda del donante (12)(13)(14)(15). La creatinina sérica es el marcador más utilizado para definir si los riñones de un posible donante son aptos para ser trasplantados (3); desafortunadamente no predice tempranamente la disfunción renal y es poca su utilidad para evaluar cambios agudos (11,16).…”

Section: Introductionunclassified

Medición del NGAL urinario en el donante para detectar función retardada del injerto renal en el receptor

Nieto-Ríos

Higuita

Ocampo-Kohn

et al. 2016

CES Med

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Comparte ResumenIntroducción: en el trasplante renal de donante fallecido es importante tener marcadores tempranos que ayuden a predecir la funcionalidad adecuada del injerto renal. La medición de creatinina continúa siendo el marcador de elección para definir si los riñones de un posible donante son aptos para ser trasplantados. La lipocalina asociada a la gelatinasa del neutrófilo urinaria (NGALu) es un biomarcador que ha sido utilizado para el diagnóstico temprano de lesión renal aguda, pero su comportamiento es incierto en el donante fallecido. Este estudio tiene como objetivo determinar si los niveles de NGALu del donante pueden predecir la función retardada del injerto (FRI) en los receptores. Metodología: cohorte prospectiva en la que se evaluaron los niveles de NGALu del donante al momento de la extracción renal; se aplicó estadística descriptiva y pruebas no paramétricas. Se exploró el comportamiento de este biomarcador en el donante del injerto renal para determinar si es un factor predictivo de función retardada del injerto. Resultados: se evaluaron 27 donantes de criterios óptimos; el 74,1 % eran hombres, la edad tuvo una mediana de 27 años (rango: 18,8-43,3); la principal causa de muerte fue trauma encefalocraneano, seguido por el accidente cerebrovascular. La creatinina tuvo una mediana de 0,8 mg/dl y los valores de NGALu tuvieron una mediana de 11,1ng/ml (4,2-33,6). En total se realizaron 46 trasplantes, de los cuales el 15,2 % presentaron función retardada del injerto y dos pacientes necesitaron terapia de reemplazo renal en la primera semana luego del trasplante. Los valores de NGALu agrupados de acuerdo a presencia o no de función retardada del injerto fueron de 11,1 ng/ml (3-17,3) en los pacientes sin función retardada del injerto y 11,2 ng/ml en los pacientes con dicha función (7,7-39,4) (p=0,40). En el análisis multivariado no se encontró ningún factor asociado al desarrollo de función retardada del injerto. Conclusión: en este estudio la medición de uNGAL en donantes fallecidos de criterios óptimos no predijo función retardada del injerto. Palabras claves:Función retardada del injerto renal, Lipocalina asociada a la gelatinasa del neutrófilo urinaria, Trasplante renal, Creatinina. MEDICINANieto-Ríos JF, Serna-Higuita M, Ocampo-Kohn C, Aristizabal-Alzate A, Lopera S, Bedoya-Londoño AM, et. al. Julio -Diciembre 2016 -Pág 149Abstract Introduction: For deceased donor renal transplantation, it is important to have early markers that can predict the functional outcome of the transplant. Currently, creatinine is the marker of choice for determining whether a potential donor's kidneys are suitable for transplantation. Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a biomarker that has been utilized to diagnose early-stage acute kidney injury, but its behavior in deceased donors is uncertain. The objective of this study was to determine whether donor uNGAL levels can predict delayed graft function in recipients. Methodology: A prospective cohort utilizing descriptive statistics and non-...

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Urine Liver-Type Fatty Acid-Binding Protein Predicts Graft Outcome up to 2 Years After Kidney Transplantation

Cited by 24 publications

References 20 publications

Mass spectrometric quantification of urinary human liver fatty acid binding protein in renal transplant recipients

Mass spectrometric quantification of urinary human liver fatty acid binding protein in renal transplant recipients

Urinary excretion of liver-type fatty acid-binding protein reflects the severity of sepsis

Medición del NGAL urinario en el donante para detectar función retardada del injerto renal en el receptor

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