Urine abnormalities predict acute kidney injury in COVID-19 patients: An analysis of 110 cases in Chennai, South India

Sundaram, Supraja; Soni, Mamta; Annigeri, Rajeev A

doi:10.1016/j.dsx.2020.12.021

Cited by 16 publications

(25 citation statements)

References 15 publications

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“…The findings of our study are in harmony with another study [16] that showed that CRP and Ddimer levels are correlated with severity of infection with COVID-19 and can be used as predictive biomarkers in adults and children [17] infected with COVID-19, However, the incidence is higher in adults [18] for COVID-19 prognosis and from the early stage of the disease emphasizing that it can also be useful in controlling and management of the disease. Our study showed that 15.15 % of adult cases showed hematuria, microscopic RBCs > 10 /HPF, these finding is in alignment with that of Sundaram et al [19] who reported significant hematuria in 17.3% of cases and with Allemailem et al [20] who reported hematuria in 22.3% of infected patients. In our study, 23 adult cases (34.8%) showed pus cells > 10 HPF coinciding with the study by Allemailem et al [20] who found that 33.7% of the studied cases had pus in their urine.…”

Section: Discussionsupporting

confidence: 91%

“…In our study, 23 adult cases (34.8%) showed pus cells > 10 HPF coinciding with the study by Allemailem et al [20] who found that 33.7% of the studied cases had pus in their urine. Another study showed lower percentage of pyuria (8.2%) in COVID-19 infected patients [19]. In the current study, there were 16 contact children (19.5%) with urine pus cells > 10 HPF, while only 5 children (6%) with urine pus cells > 10 HPF (p= 0.05).…”

Section: Discussioncontrasting

confidence: 42%

“…Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is the cause of the current pandemic of coronavirus disease 2019 (COVID- 19), which has significantly affected all aspects of life; not only the medical but the economic and social aspects as well [1].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

Hassanin

Abbas²,

Alaa³

et al. 2021

Microbes and Infectious Diseases

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Aim is to depict suggestive urine and stool parameters in asymptomatic suspected contact children living with COVID-19 infected adults. These parameters will facilitate identifying children who deserve the confirmatory diagnosis of COVID-19 by PCR test. Methods: Study was conducted in the National Hepatology and Tropical Medicine Research institute (NHTMRI) Cairo, Egypt. It included 66 mild COVID-19 adult patients (group1) and their 82 asymptomatic contact children (group 2). Results: In group 1, both C reactive protein (CRP) and D-dimer levels were significantly high. C reactive protein was significantly positively correlated with urinary microalbumin> 30, albumin/ creatinine ratio and urine pus >10 cells / HPF and significantly negatively correlated with vitamin C. Ddimer was significantly negatively correlated with vitamin C. In group 2, CRP and D-dimer were significantly negatively correlated with urine specific gravity (SG), urinary vitamin C. CRP was significantly negatively correlated with stool pus > 10 cells/ HPF, while D-dimer was significantly positively correlated with stool occult blood. Receiver Operating Curve (ROC) analysis revealed that urine SG showed the highest area under the curve (AUC); 0.859, 0.96, sensitivity of 100%, 100% and specificity of 71.8%, 77.8% with reference to Ddimer and CRP; respectively. Conclusions: In contact children of adult COVID-19 proved infection, urine SG, stool occult blood and stool pus > 10 cells/ HPF can be feasible tool for suspected COVID-19 infection, based on its results COVID-19 PCR request can be an imperative option to confirm the diagnosis; particularly in developing countries where detection of COVID -19 by PCR is not readily feasible.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 42%

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Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

Hassanin

Abbas²,

Alaa³

et al. 2021

Microbes and Infectious Diseases

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“…In previous reports, COVID-19 patients who underwent kidney biopsy showed heterogeneous kidney histologic features, including acute tubular injury, collapsing glomerulopathy, focal segmental glomerulosclerosis, tubulointerstitial nephritis, thrombotic microangiopathy [ 6 , 10 , 11 ]. Acute endothelial cell injury and podocytopathy were common histological findings in the setting of AKI, associated with collapsing glomerulopathy, and also in kidney transplant antibody-mediated rejection [ 12 ]. Our patient, instead, presented a normal native kidney function and no pre-existing conditions.…”

Section: Discussionmentioning

confidence: 99%

Renal Thrombotic Microangiopathy in Concurrent COVID-19 Vaccination and Infection

et al. 2021

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We report on the development of nephrotic proteinuria and microhematuria, with histological features of renal thrombotic microangiopathy (TMA), following the first dose of BNT162b2 COVID-19 vaccine (Pfizer-BioNTech) and COVID-19 diagnosis. A 35-year-old previously healthy man was admitted at our hospital due to the onset of foamy urine. Previously, 40 days earlier, he had received the first injection of the vaccine, and 33 days earlier, the RT-PCR for SARS-CoV-2 tested positive. Laboratory tests showed nephrotic proteinuria (7.9 gr/day), microhematuria, serum creatinine 0.91 mg/dL. Kidney biopsy revealed ultrastructural evidence of severe endothelial cell injury suggestive of a starting phase of TMA. After high-dose steroid treatment administration, complete remission of proteinuria was achieved in a few weeks. The association of COVID-19 with renal TMA has been previously described only in patients with acute renal injury. Besides, the correlation with COVID-19 vaccine has not been reported so far. The close temporal proximity (7 days) between the two events opens the question whether the histological findings should be ascribed to COVID-19 itself or to vaccine injection.

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“…Among the basic parameters determined in patients with suspected kidney injury and the acute condition are the level of serum creatinine and the eGFR index. In the case of COVID-related AKI, as in other AKI cases, serum creatinine levels are much higher compared to those of healthy individuals, and, of course, the eGFR level is significantly reduced; in almost 70% of patients, several abnormalities in the urine samples are detected and include proteinuria, hematuria, and, less frequently, leukocyturia [19,97,98]. Most patients with COVID-related AKI present an increased white blood cell count with elevated levels of neutrophils and a lowered number of lymphocytes [68].…”

Section: Laboratory Findingsmentioning

confidence: 99%

Pathophysiology and Clinical Manifestations of COVID-19-Related Acute Kidney Injury—The Current State of Knowledge and Future Perspectives

Smarz-Widelska¹,

Grywalska

Morawska

et al. 2021

IJMS

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The continually evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a vast number of either acute or chronic medical impairments of a pathophysiology that is not yet fully understood. SARS-CoV-2 tropism for the organs is associated with bilateral organ cross-talks as well as targeted dysfunctions, among which acute kidney injury (AKI) seems to be highly prevalent in infected patients. The need for efficient management of COVID-related AKI patients is an aspect that is still being investigated by nephrologists; however, another reason for concern is a disturbingly high proportion of various types of kidney dysfunctions in patients who have recovered from COVID-19. Even though the clinical picture of AKI and COVID-related AKI seems to be quite similar, it must be considered that regarding the latter, little is known about both the optimal management and long-term consequences. These discrepancies raise an urgent need for further research aimed at evaluating the molecular mechanisms associated with SARS-CoV-2-induced kidney damage as well as standardized management of COVID-related AKI patients. The following review presents a comprehensive and most-recent insight into the pathophysiology, clinical manifestations, recommended patient management, treatment strategies, and post-mortem findings in patients with COVID-related AKI.

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Urine abnormalities predict acute kidney injury in COVID-19 patients: An analysis of 110 cases in Chennai, South India

Cited by 16 publications

References 15 publications

Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children

Renal Thrombotic Microangiopathy in Concurrent COVID-19 Vaccination and Infection

Pathophysiology and Clinical Manifestations of COVID-19-Related Acute Kidney Injury—The Current State of Knowledge and Future Perspectives

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