Urinary vanillyl-mandelic acid (VMA) excretion by chronically anaemic children.

Matsaniotis, N; Beratis, N. G.; Economou-Mavrou, C.

doi:10.1136/adc.43.229.372

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Our data in NE, E and VMA excre-tion in boys and girls agree with those of previous authors (Hakulinen, 1971;Johansson, 1972;Matsaniotis et aL, 1968). In adult subjects, the sex-difference in NE and E excretion is still questioned: urinary levels in women have been found either equal (Levi, 1972) or lower (Lambert et aL, 1969) under normal activity, or equal (Claustre et al, 1980) or higher (Cuche et aL, 1975) during recumbency.…”

Section: Discussionsupporting

confidence: 93%

Sex-differences in catecholamine metabolites in human urine during development and at adulthood

Dalmaz

Peyrin

1982

J. Neural Transmission

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Adrenergic amines (dopamine [DA], norepinephrine [NE], epinephrine [E] and related compounds (DOPA, 3-methoxytyramine [MT], normetanephrine [NMN], metanephrine [MN], 3-5-dihydroxyphenylacetic acid [DOPAC], vanilmandelic acid [VMA] were analyzed in urine of human from one day to 40 years of age, in view to investigate the sex influence on catecholamine metabolism during life. In neonatal life (1 day to 3.5 months), the total amounts of urinary (E + MN) and (NE + NMN + VMA) were lower in girls than in boys, the former two compounds being mainly of adrenal medullary origin and the latter three coming largely from the sympathetic neurons. In adulthood, women excreted epinephrine (12.5 +/- 2.2 micrograms/24 hours) at lower levels then men (22.8 +/- 4.5 micrograms/24 hours) but no sex related differences occurred in the total amounts of urinary E + MN and NE + NMN + VMA. It is concluded from our study that, during the neonatal life, girls exhibit a lesser adreno-sympathetic maturity than boys, but full maturation of peripheral adrenergic sites is reached near to the fifth year of age in both sexes. The role of testosterone has been discussed. In adults, the lower epinephrine levels found in women urine do not seem to result from a sex difference in the degree of adrenergic maturity, but perhaps partly from an increased rate of epinephrine inactivation by catechol-O-methyltransferase.

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Section: Discussionsupporting

confidence: 93%

Sex-differences in catecholamine metabolites in human urine during development and at adulthood

Dalmaz

Peyrin

1982

J. Neural Transmission

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“…Catecholamines inhibit insulin release (Wilber et al, 1966). Increased urinary vanillyl-mandelic acid excretion has been found in thalassaemic subjects by Matsaniotis et al (1968). Zinc has been implicated in insulin metabolism (Chooi et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Alpha and beta cell evaluation in patients with thalassaemia intermedia and iron overload

Sanctis

Gamberini

Borgatti

et al. 1985

Postgraduate Medical Journal

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Summary:Insulin and glucagon secretion were studied during an oral glucose tolerance test and arginin infusion in 11 patients with thalassaemia intermedia, who showed laboratory evidence of iron overload. Mean blood glucose concentrations in patients with thalassaemia intermedia were significantly higher than normal and 3 of 11 patients had impaired glucose tolerance. The principal abnormality appears to be a deficiency in insulin and glucagon from the pancreas in response to oral glucose tolerance and argmine stimulation tests. Several factors, such as iron overload, chronic hypoxia, zinc deficiency and increased catecholamine production secondary to anaemia, might play a part in the pathogenesis of these abnormalities. Each of these factors affect individual cases to a varied degree. Our data emphasize the mildness of carbohydrate defect as compared to the degree of insulinopenia and indicate the necessity for prescribing measures which prevent excessive iron deposition and improve iron excretion in thalassaemic patients with iron overload.

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“…10 In addition, in health, the daily urinary excretion of, for example, VMA, increases linearly with age with no difference between boys and girls. 11 Also, it can be difficult to obtain accurately timed urine specimens from infants and children. 8,12 However, throughout childhood, the urine creatinine excretion rate also increases in a relatively linear fashion with age, and it has long been suggested that measurement of substances in casual urine specimens may be corrected to some extent by expressing results per unit creatinine.…”

Section: Introductionmentioning

confidence: 99%

Age-related medical decision limits for urinary free (unconjugated) metadrenalines, catecholamines and metabolites in random urine specimens from children

et al. 2011

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Background: Neuroblastoma is the most common extracranial solid tumour in childhood (8% of all childhood cancers), the most frequently diagnosed in infancy, and has one of the highest death rates, while chromaffin tumours rarely present in childhood. Both tumour types produce catecholamines and their metabolites. It is difficult to produce reference ranges for tests in children, and currently, no age-related medical decision limits for free metadrenalines (free metanephrines) in random urine specimens exist in the paediatric literature. Methods: Results of vanillylmandelic acid (VMA), 5-hydroxyindoleacetic acid, homovanillic acid (HVA), noradrenaline (NA), adrenaline, dopamine (DA), free normetadrenaline (fNMA), free metadrenaline and free 3-methoxytyramine (f3MT) in 1658 random urines obtained from infants, children and young adults were measured by high performance liquid chromatography with electrochemical detection. Specimens were excluded from consideration if obtained from the following categories, i.e. (a) harbouring neuroblastic, chromaffin, carcinoid or other tumours or malignancies; (b) medical conditions having known association with excess catecholamine excretion; (c) patients administered catecholamine or paracetamol; (d) overly dilute urine; and (e) manifesting outlying values following visual inspection. Results: There remained 872 specimens that were grouped into seven age ranges (,1; 1 or 2; 3 or 4; 5 -7; 8 -10; 11-13; 14-19 y) for which medical decision limits were determined for each analyte. There was no significant difference between the results for boys or girls. In 55 patients harbouring neuroblastic tumours, HVA (54/55), f3MT (14/16), VMA (45/53) and DA (43/53) were the most frequently elevated analytes at time of diagnosis. In 11 patients presenting in childhood with chromaffin tumours, fNMA (11/11) followed by NA (10/11) were the most frequently elevated. Discussion: The likely reasons for outlying or missing values, together with the reasons for variation in the distinctive biochemical patterns of analytes exhibited in individuals harbouring either neuroblastic or chromaffin tumours are discussed.

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Urinary vanillyl-mandelic acid (VMA) excretion by chronically anaemic children.

Cited by 6 publications

References 12 publications

Sex-differences in catecholamine metabolites in human urine during development and at adulthood

Sex-differences in catecholamine metabolites in human urine during development and at adulthood

Alpha and beta cell evaluation in patients with thalassaemia intermedia and iron overload

Age-related medical decision limits for urinary free (unconjugated) metadrenalines, catecholamines and metabolites in random urine specimens from children

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