Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis

Garnero, Patrick; Conrozier, T; Stephan, Carsten; Mathieu, Pierre; Delmas, Pierre D.; Vignon, E.

doi:10.1136/ard.62.10.939

Cited by 100 publications

(77 citation statements)

References 21 publications

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“…JSW is a key feature of the K/L score; therefore, it is also reassuring to find that of the 6 biochemical markers showing significant associations with the K/L score, at least 4 (COMP, HA, MMP-3, and CTX-II) are known to be associated with cartilage degradation (24)(25)(26)(27). Overall, this finding is consistent with the results of a recent study that used a more sensitive form of imaging (MRI), in which the authors observed significant associations between several of the biochemical markers investigated, notably CTX-II and COMP, and the global joint damage score (whole-organ magnetic imaging score) obtained from different MRI features (28).…”

Section: Discussionmentioning

confidence: 99%

Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?

Davis

Karl

Granell

et al. 2007

Arthritis & Rheumatism

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Objective. Osteoarthritis (OA) is a complex heterogeneous joint disease affecting more than 35 million people worldwide. The current gold standard diagnostic investigation is the plain radiograph, which lacks sensitivity. Biochemical markers have the potential to act as adjunct markers for imaging in the assessment of knee OA. We undertook this study to determine the association between individual biochemical markers and radiographic features, and to establish whether the association is strengthened when selected biochemical markers are combined into a single factor (a theoretical marker).Methods. Twenty serum and urinary biochemical markers were analyzed in 119 patients with predominantly tibiofemoral knee OA. Pearson's correlation was performed, and corresponding coefficients of determination (R 2 ) were calculated to determine the association between biochemical markers and a range of imaging features from radiographs and dual x-ray absorptiometry of the knee. Biochemical markers demonstrating a significant association (P < 0.05) with a specific imaging feature were combined by principal components analysis (PCA). Pearson's correlation was repeated to establish whether the combined panel of biochemical markers showed a stronger association with imaging than the best single marker.Results. Fourteen biochemical markers showed significant associations with one or more imaging features. By combining specific panels of biochemical markers to form factors, the association of markers with imaging features (R 2 ) increased from 11.9% to 22.7% for the Kellgren/Lawrence (K/L) score, from 5.9% to 9.2% for joint space width (JSW), from 6.6% to 10.8% for sclerosis, from 13.5% to 22.6% for osteophytes, and from 12.0% to 14.2% for bone mineral density (BMD). Biochemical markers identifying patients with osteophytes overlapped with those correlated with a high K/L score, while markers of subchondral BMD formed a completely separate group. Biochemical markers of JSW included markers associated with both osteophytes and BMD.Conclusion. The PCA results suggest that biochemical marker combinations may be more sensitive than individual biochemical markers for reflecting structural damage in patients with knee OA. The differences in biochemical marker profiles associated with osteophytes compared with those associated with subchondral BMD raise the possibility that these 2 processes, commonly seen in bone in knee OA, have underlying biologic differences.Osteoarthritis (OA) is a complex heterogeneous joint disease with a prevalence of 18% in persons age Ͼ55 years in the UK (1). With ϳ35 million people affected worldwide, OA is a major cause of pain and disability, and its incidence is increasing as life expectancy continues to rise (2). The current gold standard for diagnosing OA is the plain radiograph, which has many methodologic shortcomings, and, in spite of efforts to improve techniques (3,4), inaccuracies may occur from subtly different views of the image, degree of flexion, intra-and interobserver discrepancies, and "anticip...

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Section: Discussionmentioning

confidence: 99%

Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?

Davis

Karl

Granell

et al. 2007

Arthritis & Rheumatism

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“…Control [1,5,12,18,19,49]; atrophic versus hypertrophic in two studies [13,14]; and radiographic OA classification in five studies [6,23,42,47,48]. Two studies [15,20] analyzed minimum joint space width as a continuous variable relative to biomarker levels.…”

Section: Literature Searchmentioning

confidence: 99%

“…A total of 16 different biomarkers demonstrated differences between patients with hip OA and non-OA control subjects (Table 2) Although most biomarkers were assessed in only one ''diagnosis'' study, urinary level of type II collagen telopeptide (uCTX-II) [19,22,37] and serum C-reactive protein (CRP) [11,21,27] levels both were increased in patients with hip OA in more than one study. In three studies [19,22,37], uCTX-II levels were elevated in patients with hip OA 1.3 to 3.1 times that of the control group with associated effect size (d) of 2.2 to 3.7.…”

Section: Diagnosismentioning

confidence: 99%

“…In three studies [19,22,37], uCTX-II levels were elevated in patients with hip OA 1.3 to 3.1 times that of the control group with associated effect size (d) of 2.2 to 3.7. Serum CRP level was elevated in patients with hip OA compared with control subjects in two studies (2.1-8.2 times greater than control levels, d 1.0-28.7) [11,21] while failing to demonstrate an effect in another study [27].…”

Section: Diagnosismentioning

confidence: 99%

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What Is the Utility of Biomarkers for Assessing the Pathophysiology of Hip Osteoarthritis? A Systematic Review

Nepple

Thomason

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…Initially, the disease affects articular cartilage in which the most abundant protein is collagen type II. Accordingly, urinary levels of type II collagen C-telopeptide (CTX-II) have been reported to be significantly higher in patients with rapidly destructive hip OA than in patients with slowly progressive hip OA [8]. Increased levels of matrix metalloproteinases (MMP-3 and -9) and decreased levels of tissue inhibitor of matrix metalloproteinases (TIMP) in serum and joint fluid have pointed to a basic involvement of MMP in the pathogenesis of rapidly destructive hip OA [3,12,16].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip

Berger

Kröner

Stiegler

et al. 2004

International Orthopaedics (SICOT)

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We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.Résumé Nous avons comparé la dégradation du collagène type I en utilisant le cross-linking du telopeptide Terminal C (ICTP) chez 18 malades avearthrose rapidement destructrice et chez 20 malades avecarthrose lentement progressive de la hanche. Le diagnostic a été établi par examen clinique et évaluation radiographique. L'arthroplastie totale de la hanche a été exécuté chez tous les malades. Le niveau sérique d'ICTP, des phosphatases alcalines osseuse spécifiques, de l'ostéocalcine, et du propeptide N-Terminal a été étudié. Les malades avec arthrose rapidement destructrice avaient une moyenne du niveau d'ICTP nettement plus haute que les malades avec arthrose lentement progressive [13.2 (5.6) vs 3.7 ng/ml (1.4), p=0.001], alors qu'aucune différence notable de tous les autres marqueurs n'a été notée entre les groupes. L'élévation de niveau de l› ICTP était en corrélation avec la hauteur de l'interligne articulaire apprécié par des radiographies (p=0.01). Nos données suggèrent que l'arthrose rapidement destructive est associé à une élévation sérique de l'ICTP reflétant une augmentation de la dé-gradation du collagène de type I.

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Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis

Cited by 100 publications

References 21 publications

Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?

Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?

What Is the Utility of Biomarkers for Assessing the Pathophysiology of Hip Osteoarthritis? A Systematic Review

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip

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