Urinary tract infections at first antenatal check-up: a single centre prospective study

Jena, Saubhagya Kumar; Panigrahy, Rajashree; Mishra, Lipsa; Das, S. N.; Samal, Soumya

doi:10.18203/2320-1770.ijrcog20162994

Cited by 2 publications

(5 citation statements)

References 10 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, 32.5% of Enterobacteriaceae were identified as ESBL producers. Similar high rates were observed in both community [43][44][45] and hospitalized a pregnant women. This represents a challenge in treatment because these organisms are resistant to cephalosporins, which have a well-established safety profile in pregnancy.…”

Section: Discussionsupporting

confidence: 80%

Phenotypic and Genotypic Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Asymptomatic Bacteriuria in Pregnancy

Youssef

Rizk

Hassuna

2019

Microbial Drug Resistance

View full text Add to dashboard Cite

Asymptomatic bacteriuria (ASB) has been consistently observed in pregnancy. However, there is a paucity of data on the prevalence and characteristics of extended-spectrum b-lactamase (ESBL)-producing Enterobacteriaceae in ASB in pregnant women. Therefore, we sought to investigate ESBL-producing and multidrug-resistant Enterobacteriaceae in antenatal women with ASB. Urine samples were collected from 310 asymptomatic pregnant women attending primary antenatal clinics and screened for significant bacteriuria. Isolates of Enterobacteriaceae were phenotypically tested for their ESBL production. ESBL genes (CTX-M, TEM, and SHV genes) were then amplified by polymerase chain reaction (PCR). Multiplex PCRs were used to perform phylogenetic typing of ESBLproducing Escherichia coli isolates and to examine the commonality of sequence type 131 (ST131)-O25b and ST131-O16. A total of 103 (33.2%) pregnant women were positive for significant bacteriuria (80 Enterobacteriaceae). Of these isolates, 32.5% (n = 26) were ESBL producers and had a higher rate of multidrug resistance than non-ESBL producers. Genotypic characterization of ESBL-producing isolates showed that 84.6% had the bla CTX-M gene (bla CTX-M-15 = 77.3%; bla CTX-M-9 = 18.2%). None of the isolates were of the TEM or SHV type. Half of the ESBLproducing E. coli isolates were of the phylogroup B2, and 4 (20%) isolates were of the ST131-O16 clonal subgroup. This study is the first in Egypt to provide evidence for the high prevalence of ESBL-producing Enterobacteriaceae in pregnant women with ASB. It also represents an important step toward genotypic characterization of this resistant form of bacteria, which may be useful for future antimicrobial studies.

show abstract

Section: Discussionsupporting

confidence: 80%

Phenotypic and Genotypic Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Asymptomatic Bacteriuria in Pregnancy

Youssef

Rizk

Hassuna

2019

Microbial Drug Resistance

View full text Add to dashboard Cite

show abstract

“…Of the 23 studies mentioned above, 6 studies were conducted in Africa, 2 studies in North America, 1 study in South America, 12 studies in Asia, and 2 studies in Europe . We contacted authors of 20 studies for more clarifications about their reports.…”

Section: Resultsmentioning

confidence: 99%

“…Table presents the quality assessment for risk of bias in each study. Of 23 included studies, 17 studies had high quality and 6 studies had low quality …”

Section: Resultsmentioning

confidence: 99%

“…America, 32 12 studies in Asia, [33][34][35][36][37][38][39][40][41][42][43][44] and 2 studies in Europe. 45,46 We contacted authors of 20 studies for more clarifications about their reports.…”

Section: Esbl-producing Enterobacteriaceaementioning

confidence: 99%

“…For studies that lasted for more than 12 months, the midyear of the study period that actual sampling and laboratory evaluation was done was determined as the date of the study. Nine studies reported data on patients with symptomatic UTI, 24,27,29,[31][32][33]43,44,46 nine reported AB, 25,26,[34][35][36][37][40][41][42] and infection type in five studies 28,30,38,39,45 were indeterminate. Two studies included postpartum women.…”

Section: Esbl-producing Enterobacteriaceaementioning

confidence: 99%

See 2 more Smart Citations

Extended‐spectrum beta‐lactamase (ESBL)‐producingEnterobacteriaceaeand urinary tract infections in pregnant/postpartum women: A systematic review and meta‐analysis

et al. 2019

View full text Add to dashboard Cite

Background Urinary tract infections (UTI) and asymptomatic bacteriuria (AB) during pregnancy can result in considerable maternal and foetal adverse outcomes. Production of extended‐spectrum beta‐lactamase (ESBL) is a major antibiotic resistance mechanism by Enterobacteriaceae. Objectives To determine the global prevalence of ESBL‐producing (ESBL‐P) Enterobacteriaceae in symptomatic UTI/AB among pregnant/postpartum females. Data sources A systematic review of the PubMed, Embase, Scopus, WOS (Web of Science), ProQuest and the grey literature was conducted. Study selection and data extraction Studies that reported the frequency of ESBL‐P Enterobacteriaceae in pregnant/postpartum women with UTI and/or AB were eligible. First, the titles and abstracts of the retrieved articles were reviewed. Then, the full texts of the remained articles were reviewed. Synthesis In order to estimate the pooled prevalence and the 95% confidence interval (95% CI), meta‐analysis was performed using the random‐effects model. Results Twenty‐three studies (six from Africa, two from North America, one from South America, 12 from Asia and two European studies) that reported data on 20 033 Enterobacteriaceae strains were included. The pooled prevalence of ESBL‐P Enterobacteriaceae was 25% (95% CI 18%, 32%); I2 = 98.8%. The estimated prevalence (95% CI) rates were 45% (22, 67%) in Africa, 33% (22, 44%) in India, 15% (6, 24%) in other Asian countries, 5% (2, 8%) in Europe, 4% (1, 11%) in South America and 3% (1, 5%) in North America (P < .001). This estimate was 21% (95% CI 11, 31%) in patients with symptomatic UTI and it was 28% (95% CI 15, 41%) in patients with AB (P = .40). Conclusions The prevalence of ESBL‐P Enterobacteriaceae among pregnant women with UTI/AB was significant and geographic region was a major source for heterogeneity. The findings could be taken into account by healthcare providers and programmers in the management and antibiotic selection of UTI/AB during pregnancy, especially in high prevalence areas.

show abstract

Urinary tract infections at first antenatal check-up: a single centre prospective study

Cited by 2 publications

References 10 publications

Phenotypic and Genotypic Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Asymptomatic Bacteriuria in Pregnancy

Phenotypic and Genotypic Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Asymptomatic Bacteriuria in Pregnancy

Extended‐spectrum beta‐lactamase (ESBL)‐producingEnterobacteriaceaeand urinary tract infections in pregnant/postpartum women: A systematic review and meta‐analysis

Contact Info

Product

Resources

About