Urinary tract infection’s etiopathogenic role in nephrolithiasis formation

Bauzá, Jose Luis; Pieras, Enrique; Gráses, F.; Tubau, V.; Guimerà, J.; Sabaté, X.A.; Piza, Pedro de Toledo

doi:10.1016/j.mehy.2018.06.002

Cited by 15 publications

(15 citation statements)

References 17 publications

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“…As emphasized by Borghi et al [72], the relationship between nephrolithiasis and urinary tract infections is complex and difficult to analyse both from a pathophysiological and clinical point of view. This has prompted several investigations to understand the relationship between infection and urinary stones [73,74], most of them focussing on struvite [75][76][77][78][79][80][81]. Here we attempt to broaden the scope of studies of this pathogenesis by describing in detail the physicochemical characteristics of stones containing Wk without struvite.…”

Section: Results and Commentsmentioning

confidence: 99%

Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation

Bazin¹,

Papoular²,

Elkaı̈m³

et al. 2022

Comptes Rendus. Chimie

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Section: Results and Commentsmentioning

confidence: 99%

Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation

Bazin¹,

Papoular²,

Elkaı̈m³

et al. 2022

Comptes Rendus. Chimie

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“…Regarding clinical presentation, UTI is associated with flank or abdominal pain (70%), typical renal colic (rare), fever (26%), gross haematuria (18%), and sepsis (1%), but can be asymptomatic (8%incidental diagnosis). Infection of the urinary system may lead to the formation of concretions [4][5][6][7][8][9] as well as an incrustation of JJ stents [10][11][12][13]. It is well known that infection stones form secondary to urease-splitting organisms such as Proteus, Klebsiella, Pseudomonas, or Staphylococcus, among others.…”

Section: Introductionmentioning

confidence: 99%

Urinary tract infection inducing stones: some clinical and chemical data

Daudon¹,

Petay²,

Vimont³

et al. 2022

Comptes Rendus. Chimie

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Most papers on kidney stones arising from infection concentrate on the mineral struvite. In this contribution, we would like to call attention to other mineral phases such as highly carbonated calcium phosphate apatite, ammonium urate, and whitlockite, by presenting clinical and chemical data. We start with epidemiological data which emphasize the increase in the prevalence of kidney stones related to infection. Then we present a statistical analysis of more than 85,000 stones which have been analysed at the Laboratoire des Lithiases of Assistance Publique-Hôpitaux de Paris which gives insights regarding the link between urinary tract infection and struvite, carbonated calcium phosphate apatite (carbapatite), and also surprisingly whitlockite. Some information regarding the pathogenesis of kidney stones linked to infection, the nature of the bacteria which have been identified, and the approach to precisely analyse infrared spectra to identify struvite, carbapatite, and whitlockite, conclude this first part. To complete this clinical description, we describe the crystallographic structure and the chemistry of three relevant compounds namely carbonated calcium phosphate, struvite, and whitlockite. To conclude this second part, the dependence of crystallite morphology of struvite on pH and on the presence, or absence, of bacteria, is described. Based on clinical and * Corresponding author.

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“…Currently, there are many theories explaining the causes and mechanisms of pathogenic stone formation in the human urinary system [3][4][5][6][7][8][9][10]. All theories are based on the complex interaction of biogenic and abiogenic substances, but none of them are exhaustive.…”

Section: Introductionmentioning

confidence: 99%

“…All theories are based on the complex interaction of biogenic and abiogenic substances, but none of them are exhaustive. The least studied is the bacterial theory [4].…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that the presence of a variety of bacteria in the urine is very likely and bacterial inflammation often accompanies stone formation [11]. Assumptions about the significant effect of microorganisms on the processes of lithiasis in the human urinary system have been made in a number of works [2][3][4][5][6][7][8][9][10][11][12][13]. The crystallization system (urine) contains about a dozen bacteria species.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bacterial Effect on the Crystallization of Mineral Phases in a Solution Simulating Human Urine

et al. 2019

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The effect of bacteria that present in the human urine (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus) was studied under the conditions of biomimetic synthesis. It was shown that the addition of bacteria significantly affects both the phase composition of the synthesized material and the position of crystallization boundaries of the resulting phosphate phases, which can shift toward more acidic (struvite, apatite) or toward more alkaline (brushite) conditions. Under conditions of oxalate mineralization, bacteria accelerate the nucleation of calcium oxalates by almost two times and also increase the amount of oxalate precipitates along with phosphates and stabilize the calcium oxalate dihydrate (weddellite). The multidirectional changes in the pH values of the solutions, which are the result of the interaction of all system components and the crystallization process, were analyzed. The obtained results are the scientific basis for understanding the mechanisms of bacterial involvement in stone formation within the human body and the creation of biotechnological methods that inhibit this process.

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Urinary tract infection’s etiopathogenic role in nephrolithiasis formation

Cited by 15 publications

References 17 publications

Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation

Whitlockite structures in kidney stones indicate infectious origin: a scanning electron microscopy and Synchrotron Radiation investigation

Urinary tract infection inducing stones: some clinical and chemical data

Bacterial Effect on the Crystallization of Mineral Phases in a Solution Simulating Human Urine

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