THE mechanism of function of distal urethral stenosis in relation to urinary tract infection is unclear. It is agreed that the calibre of the distal urethral ring is not obstructive in itself, yet its symptomatology and sequelae are, at least partly, of obstructive nature (Lyon and Smith, 1963;Lyon and Tanagho, 1965). Interest in the problem prompted us to do detailed physiological studies in order to define the obstructive mechanism.We studied 2 groups of patients: Group 1.-Girls with recurrent lower urinary tract infections (after failure to cure them)Group 1I.-Girls with distal urethral stenosis (studied both before and after treatment) Surprisingly, the findings in the 2 groups were very similar and incriminated a common -6 patients.-2 patients.
aetiology.Material and Method of Study.-Group I.-Six girls were specifically selected because of persistence or recurrence of their urinary tract infections despite our repeated attempts with every known means of treatment. Urethral dilatation at least twice and adequate specific antibacterial therapy were tried. There was no demonstrable vesico-ureteral reflux.Group 11.-Two other girls who had presenting symptoms typical of distal urethral stenosis with urinary tract infection were also chosen for the present studies, which were done after clearance of their infections, yet before any diagnostic urethral calibration or endoscopic examination. Five to 6 months after urethral dilatation and treatment, the studies were repeated.The studies combined cineradiography with pressure measurements. Details of this technique have been reported before (Tanagho et al., 1966). In the present study, the following information was recorded:1. Intravesical pressure. 2. Proximal urethral pressure. 3. Midurethral pressure. 4. A profile of urethral pressure from the internal meatus to the external meatus. These 4 pressures were obtained with a specially constructed pressure-measuring catheter (modified from Enhorning) (Enhorning, 1961 ; Drouin and McCurry, 1969). 5. Rectal pressure indicating intra-abdominal pressure. 6. Anal sphincter pressure. The last 2 pressures were recorded using a special rectal catheter with one balloon at the end placed high in the rectum for recording intra-abdominal pressure. Another balloon in the anal sphincter region recorded its activity. This is also a measurement for the activity of the pelvic floor as a unit.7. Urine flow rate in C.C. per sec. and volume voided. 8. Cineradiographic image. 9. Measurements were timed and recorded with sound on video tape as well as o n motion