Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever

Patel, Nehal; Farooqi, Ahmad; Callaghan, Michael U.; Sethuraman, Usha

doi:10.3390/jcm9051531

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…The chest X-ray is mandatory in Sickle cell patient presenting with respiratory features. The radiologic result of infiltration presenting as opacity in COVID-19 positive patients or Sickler patients indicating acute chest syndrome [5][6][7][8][9][10][11][12][13][14][15][16]. According to current study of radiological investigation, the infiltration of different lung lobe found to be in 37.2% indicate involvement of lung tissues however associated complication of covid19 pulmonary infection such as cardiac effusions in 4.6% and pulmonary embolism in 4.6%.…”

Section: Discussionmentioning

confidence: 93%

“…In fact, the infection, hypoxia, dehydration, or acidosis inked to clinical and laboratory presentation are aggravating factors to vasoocclusive crisis [1]. Since the respiratory infection is aggravating factors to acute chest syndrome [1], the acute chest syndrome mimics clinical features and investigations of covid19 respiratory infection from mild to severe conditions [5][6][7][8][9][10][11][12][13][14][15][16]. In current study, the sickle cell anemia present with vascooclusiove pain due to covid19 infection which has been approved by nasopharyngeal swap in all cases of different days of admission with a majority of first and third days due to clinical features presentation.…”

Section: Discussionmentioning

confidence: 99%

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Mortality of covid19 in sickle cell disease systematic review

AlTalalwah¹,

AlDorazi²

2021

World J. Adv. Res. Rev.

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The covid19 infection is pandemic disease are more commonly in chronic diseases. As covid19 case pulmonary infection, the current study focuses on sickle cell disease patients are suitable to acute chest syndrome. It will clarify the risk factors for covid19 infection and its clinical features in sickle cell disease. It also reviews the radiological findings to gain more data on this pandemic disease. The current study includes 44 cases of sickle cell disease having covid19 infection. The entire cases include sickle cell disease only in 89% whereas the other sickle cell disease cases are coexisted with beta- thalassemia in 9.1%. The fourth decade is the highest peak incidence. There are several complications found to be in sickle cell disease are acute chest syndrome, chronic leg ulcer, renal failure exceeding 10%. The bronchial asthma found to be in 6.9% and avascular necrosis found to be 11.4% whereas the cerebrovascular accident found to be in 13.8%. The radiological changes include lung tissues, alveoli, pleural cavities and pulmonary arteries in different rate. The incidence of recovery found to be in 93% whereas the death found to be in 7%. It found to be involving in respiratory and gastrointestinal systems result in different clinical features in different rate. This study compares the clinical features, findings investigation and complications between sex and decades. Further, this study clarifies recovery and mortality rate between sex and decades. Knowing and understanding covid19 infection in sickle cell disease, physicians will be able to provide high quality of medical services.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Mortality of covid19 in sickle cell disease systematic review

AlTalalwah¹,

AlDorazi²

2021

World J. Adv. Res. Rev.

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“…Interestingly, the authors were not able to confirm this hypothesis by analysis of urinary samples of 167 febrile children (<4 years of age) with sickle cell anemia. With 4.1% of urinary infections, the rate of urinary tract infections was as high as in non-sickle cell anemia children [ 4 ].…”

Section: Epidemiology Of Sepsis (Three Publications)mentioning

confidence: 99%

Sepsis: Current Clinical Practices and New Perspectives: Introduction to the Special Issue

Hecker

Padberg

Hecker

2021

JCM

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“…Urinary tract infections (UTIs) are more common in African children of the same age with SCD than in children without SCD [6][7][8][9]. Its incidence has also been reported in children living in the USA, with a diagnosis rate of 4% [9]. UTI affects the quality of life of SCD patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Urinary Tract Infections and Antibiogram of Bacteria Isolated From Children With Sickle Cell Disease in Tanzania

Sangeda,

Yohana,

Jonathan

et al. 2024

Cureus

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Introduction Individuals with sickle cell disease (SCD) are particularly vulnerable to urinary tract infections (UTIs) due to immunological deficits and renal abnormalities associated with the disorder. These infections can exacerbate underlying health issues and lead to severe complications if not managed promptly and effectively. Due to the heightened risk and potential consequences of UTIs in this population, this study aimed to determine their prevalence and explore the resistance patterns of causative pathogens among children attending the SCD Clinic at Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania. Focusing on this demographic group, we sought to provide targeted insights to inform better clinical protocols and intervention strategies in regions heavily affected by SCD. Materials and methods This prospective cross-sectional study was conducted at the MNH, Dar es Salaam, Tanzania, with an enrollment over two months from 19 th March to 21 st May 2015. We diagnosed UTIs in children with SCD using dipstick and culture methods. Antibiotic susceptibility was assessed using the Kirby-Bauer disc diffusion method, evaluating resistance patterns to antibiotics such as ampicillin, cloxacillin, erythromycin, chloramphenicol, ceftriaxone, and trimethoprim-sulfamethoxazole. The diagnostic accuracy of the dipstick and culture methods was validated to ensure reliability in detecting UTIs. Statistical analysis was conducted using Statistical Product and Service Solutions (SPSS) software (Released 2019; IBM Corp., Armonk, New York, United States). Results Among the 250 children, 56 (22.4%) were UTI-positive according to the culture method and 62 (24.8%) were UTI-positive according to the dipstick test. Girls were more likely to be UTI-positive than boys (29.1% and 13.6%, respectively; p-value = 0.011). Escherichia coli was the most common uropathogen, followed by Klebsiella, Staphylococcus, Proteus, and Pseudomonas (44.2%, 26.9%, 21.2%, 3.8%, and 1.9%, respectively). All isolates were resistant to ampiclox. Resistance rates to ampicillin, erythromycin, cotrimoxazole, chloramphenicol, and ceftriaxone were 94.2%, 76.9%, 59.6%, 46.2%, and 21.2%, respectively. Conclusion This study indicated that dipsticks diagnosed more UTIs. The prevalence was higher in girls than in boys. Escherichia coli was the most commonly isolated antibiotic-resistant organism. High resistance levels were observed against the combination of ampicillin and cloxacillin. However, the isolates were less resistant to ceftriaxone. These results call for increased surveillance of resistant uropathogens in the pediatric population with SCD.

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Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever

Cited by 5 publications

References 19 publications

Mortality of covid19 in sickle cell disease systematic review

Mortality of covid19 in sickle cell disease systematic review

Sepsis: Current Clinical Practices and New Perspectives: Introduction to the Special Issue

Prevalence of Urinary Tract Infections and Antibiogram of Bacteria Isolated From Children With Sickle Cell Disease in Tanzania

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