Urinary tract infection in children with nephrotic syndrome: A systematic review and meta-analysis

Sorkhi, Hadi; Riahi, Seyed Mohammad; Ebrahimpour, Soheil; Shaikh, Nader; Rostami, Ali

doi:10.1016/j.micpath.2019.103718

Cited by 9 publications

(10 citation statements)

References 42 publications

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“…The causes of UTIs in nephrotic children include a low level of serum IgG, hypoproteinemia, decreased bactericidal activity of the leukocytes, declined perfusion of the spleen, corticosteroids treatment, and loss of properdin in the urine. 26 M. morganii should be placed as a clinically significant pathogen in the causative possibilities of UTIs in nephrotic children. One patient was detected left ureteropelvic junction obstruction which is an established risk factor for recurrent UTIs.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike the Turkish research, 9 all of our patients have comorbidities, the most common of which is nephrotic syndrome (72.7%, 8/11). The causes of UTIs in nephrotic children include a low level of serum IgG, hypoproteinemia, decreased bactericidal activity of the leukocytes, declined perfusion of the spleen, corticosteroids treatment, and loss of properdin in the urine 26 …”

Section: Discussionmentioning

confidence: 99%

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Morganella morganii: An unusual analysis of 11 cases of pediatric urinary tract infections

Shi

Chen

Yao

et al. 2022

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Morganella morganii: An unusual analysis of 11 cases of pediatric urinary tract infections

Shi

Chen

Yao

et al. 2022

Clinical Laboratory Analysis

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“…But in the recent study from India, prevalence is found to be 29.6%[ 20 ] and much higher than pooled prevalence of 21.6% all over the world. [ 21 ] The highest prevalence is found in the African region (34.8%), and lowest in the region of the Americas (7.4%). [ 21 ] The lowest prevalence rates were reported from USA (3.3%) while the highest from Indonesia (45.9%).…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 ] The highest prevalence is found in the African region (34.8%), and lowest in the region of the Americas (7.4%). [ 21 ] The lowest prevalence rates were reported from USA (3.3%) while the highest from Indonesia (45.9%). [ 21 ] These varying prevalence in different regions may be attributed to different environmental and socioeconomic factors such as sanitation, availability of medical facilities, and awareness regarding preventing measures.…”

Section: Discussionmentioning

confidence: 99%

Urinary tract infection in children with Nephrotic syndrome: One of the hurdles for primary care physician and pediatrician towards timely diagnosis and optimum management of the disease

Mohan

Indurkar²,

Omar³

et al. 2022

Journal of Family Medicine and Primary Care

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A BSTRACT Background: Urinary tract infection (UTI) is a common infection in children with nephrotic syndrome (NS). Clinical experience suggests that childhood nephrotic syndrome is frequently diagnosed incorrectly and managed inadequately on the top of this existing UTI in the episode becomes an additive obstacle for the primary care physicians or pediatricians towards optimum management, leading to poor outcome. So, we have conducted this clinico- microbiological study of UTI in NS in children to provide the exact picture of UTI with NS so that the primary care providers can be helped in having high index of suspicion of this infection and knowing prevalent organisms and their antimicrobial sensitivity pattern. Aim: The aim of the study was to study clinical features and identify the responsible organisms with its drug sensitivity pattern with response to treatment in various types and stages of NS with UTI in children. Methods: This cross-sectional hospital based study was conducted on 50 children of 2-18 years of age with NS attending nephrology clinic or admitted to the Paediatric ward of AIIMS, Rishikesh. Demographic, clinical, and microbiological data were recorded and details were entered in a predesigned proforma sheet. Results: Out of 50 cases, 8 (16%) had a positive urine culture. Six (75%) out of them had first episode and two (25%) were frequent relapsers of NS. Fever, decreased urine output, and generalized edema were the presenting features. The most common bacteria responsible for UTI was Pseudomonas aeruginosa (in around 25% isolates). Escherichia coli and Citrobacter koseri were the most resistant organisms. Patients were treated with antibiotics according to sensitivity pattern which resulted in resolution of symptoms and repeat urine culture became sterile subsequently. Conclusion: About one-sixth of children with Nephrotic Syndrome had UTI. UTI should be ruled out in every case of NS in active phase to prevent long-term morbidity and mortality.

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“…The incidence rate of UTI varies from 4% to 0.4% in school age and preschool children. In children with PNS, the incidence of UTI is about 30% (11).…”

Section: Original Articlementioning

confidence: 99%

The risk factors for children with primary nephrotic syndrome: a systematic review and meta-analysis

Zheng¹,

Chen²,

Jing³

et al. 2021

Transl Pediatr

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Urinary tract infection in children with nephrotic syndrome: A systematic review and meta-analysis

Cited by 9 publications

References 42 publications

Morganella morganii: An unusual analysis of 11 cases of pediatric urinary tract infections

Morganella morganii: An unusual analysis of 11 cases of pediatric urinary tract infections

Urinary tract infection in children with Nephrotic syndrome: One of the hurdles for primary care physician and pediatrician towards timely diagnosis and optimum management of the disease

The risk factors for children with primary nephrotic syndrome: a systematic review and meta-analysis

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