Urinary tract infection due to Aeromonas spp., a lesser known causative bacterium

Mandal, Jharna; Dhodapkar, Rahul; Acharya, N Srinivas; Sastry, Apurba; Parija, Subhash Chandra

doi:10.3855/jidc.1052

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…In the English-language articles, previous reported cases about Aeromonas species related urinary tract infection were caused by A. hydrophila, A. veronii biotype sobria, Aeromonas popoffii, A. caviae, Aeromonas schubertii, 2e6 and Mandal et al showed that A. caviae was the most common species which caused urinary tract infection in four patients in their series of 7 cases. 2 In contrast, A. hydrophila causes more than half of the infections in this series. Moreover, it is the first time to report that mixed genitourinary infection caused by A. caviae and A. veronii at the same time.…”

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confidence: 81%

Aeromonas genitourinary tract infection

Chao

Gau

Lai

2012

Journal of Infection

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confidence: 81%

Aeromonas genitourinary tract infection

Chao

Gau

Lai

2012

Journal of Infection

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“…Treatment with carbapenems is effective, although some cases of pneumonia have been fatal [223]. Aeromonas were also described as a causal agent in urinary tract infections [5,224,225]. The majority of the cases were reported in patients with various underlying diseases, such as spina bifida, bilateral renal dilatation, and diabetes mellitus.…”

Section: Other Infectionsmentioning

confidence: 99%

An Update on the Genus Aeromonas: Taxonomy, Epidemiology, and Pathogenicity

2020

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The genus Aeromonas belongs to the Aeromonadaceae family and comprises a group of Gram-negative bacteria widely distributed in aquatic environments, with some species able to cause disease in humans, fish, and other aquatic animals. However, bacteria of this genus are isolated from many other habitats, environments, and food products. The taxonomy of this genus is complex when phenotypic identification methods are used because such methods might not correctly identify all the species. On the other hand, molecular methods have proven very reliable, such as using the sequences of concatenated housekeeping genes like gyrB and rpoD or comparing the genomes with the type strains using a genomic index, such as the average nucleotide identity (ANI) or in silico DNA–DNA hybridization (isDDH). So far, 36 species have been described in the genus Aeromonas of which at least 19 are considered emerging pathogens to humans, causing a broad spectrum of infections. Having said that, when classifying 1852 strains that have been reported in various recent clinical cases, 95.4% were identified as only four species: Aeromonas caviae (37.26%), Aeromonas dhakensis (23.49%), Aeromonas veronii (21.54%), and Aeromonas hydrophila (13.07%). Since aeromonads were first associated with human disease, gastroenteritis, bacteremia, and wound infections have dominated. The literature shows that the pathogenic potential of Aeromonas is considered multifactorial and the presence of several virulence factors allows these bacteria to adhere, invade, and destroy the host cells, overcoming the immune host response. Based on current information about the ecology, epidemiology, and pathogenicity of the genus Aeromonas, we should assume that the infections these bacteria produce will remain a great health problem in the future. The ubiquitous distribution of these bacteria and the increasing elderly population, to whom these bacteria are an opportunistic pathogen, will facilitate this problem. In addition, using data from outbreak studies, it has been recognized that in cases of diarrhea, the infective dose of Aeromonas is relatively low. These poorly known bacteria should therefore be considered similarly as enteropathogens like Salmonella and Campylobacter.

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“…Earlier studies have reflected on the drug resistance mechanisms in this group. In a study from Kolkata, India, it was observed that many of the Aeromonas strains were resistant to furazolidone, quinolones and cephalosporins [ 5 ]. In fact, multiple drug resistance among Aeromonas spp.…”

Section: Discussionmentioning

confidence: 99%

“…Susceptibility to the antibiotics varies according to the geographical area and the species of Aeromonas tested. Most of the isolates are generally susceptible to tetracyclines and quinolones though development of increasing resistance to third generation cephalosporins due to the production of beta-lactamases and extended spectrum beta-lactamases (ESBLs) has been noted in the recent years [ 2 , 3 , 5 ]. The current study was undertaken to characterize the third generation cephalosporin-resistant strains of Aeromonas spp.…”

Section: Introductionmentioning

confidence: 99%

Characterization of ceftriaxone-resistant Aeromonas spp. isolates from stool samples of both children and adults in Southern India

Bhaskar

Dinoop

Mandal

2015

J Health Popul Nutr

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BackgroundAeromonas species can cause a wide spectrum of illnesses varying from intestinal to extra intestinal and vary in their susceptibility to different antibiotics. The current study was undertaken to characterize the third generation cephalosporin-resistant strains of Aeromonas spp. which were isolated from stool specimens.MethodsOut of a total of 2780 stool samples, 29 Aeromonas spp. were identified, out of which, 9 were resistant to ceftriaxone by the Kirby-Bauer antibiotic testing method. These strains were subjected to minimum inhibitory concentration (MIC) determination by agar dilution for ceftriaxone. Phenotypic and genotypic testing of AmpC beta-lactamase and extended spectrum beta-lactamase (ESBL) were performed. Gene transfer was carried out to demonstrate transmissibility of these genetic elements by conjugation experiments.ResultsOut of the 29 strains, 9 showed MIC of ≥4 μg/ml. Seven out of 9 showed presence of blaCTX-M, while 2 more strains showed the presence of inducible AmpC beta-lactamase and presence of MOX gene. Gene transfer experiments showed that these elements were transmissible to recipient (Escherichia coli J53 strain) in the presence of ceftriaxone.ConclusionsDissemination of these resistance determinants like plasmids is pivotal in the spread of these resistance genes into the aquatic environment into organisms like Aeromonas. This may further limit the future use of antibiotics for the treatment of diarrhoeal diseases. Hence, detection and antibiotic susceptibility testing of Aeromonas spp. should be performed when isolated from stool samples.

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Urinary tract infection due to Aeromonas spp., a lesser known causative bacterium

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Cited by 11 publications

References 9 publications

Aeromonas genitourinary tract infection

Aeromonas genitourinary tract infection

An Update on the Genus Aeromonas: Taxonomy, Epidemiology, and Pathogenicity

Characterization of ceftriaxone-resistant Aeromonas spp. isolates from stool samples of both children and adults in Southern India

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