Urinary Tract Infection Due to Coagulase-negative Staphylococcus

Lewis, Jay F.; Brake, S; Anderson, Debra; Vredeveld, Gene N.

doi:10.1093/ajcp/77.6.736

Cited by 22 publications

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“…Coagulase-negative staphylococci are a common cause of prosthetic valve endocarditis, 4 " 7 and ventriculo-atrial shunts frequently become colonized and ultimately infected with this organism as well. 8 -9 Infections of other types of intravascular devices, such as central venous catheters, have been reported, 10 " 14 as have urinary tract infections 15 and focal and generalized sepsis in compromised hosts. 10 "' 22 The isolation of coagulase-negative staphylococci from blood cultures is a frequent occurrence which often presents the clinician with the difficult task of deciding if the culture reflects true bacteremia or contamination from the skin.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Clinical Significance of Blood Cultures Positive for Coagulase-Negative Staphylococcus

1985

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Coagulase-negative staphylococci are frequently isolated from blood cultures. As these organisms may occasionally cause serious disease, differentiating bacteremia from contamination is very important but often difficult. Over a 26-month period, of 29,542 blood cultures processed at the University of Michigan Medical Center, 2,875 (9.7%) were positive, and of those, 694 (from 527 patients) grew coagulase-negative staphylococci. Isolates from the 439 patients with only one blood culture positive for coagulase-negative staphylococci and those from the 18 patients with two positive cultures 10 days or more apart were deemed contaminants. Review of the records of the remaining 70 patients with multiple isolates indicated that 33 had had an episode of true bacteremia, 29 (87.9%) of which were associated with intravascular catheters or prosthetic valves. Overall, 85% of all coagulase-negative staphylococci isolated during the study period were judged to be contaminants. Seventy-one percent of the blood cultures drawn during the episodes of bacteremia were positive for coagulase-negative staphylococci as opposed to only 34% in the patients with contaminated cultures (p less than 0.01). Moreover, coagulase-negative staphylococci grew in both aerobic and anaerobic bottles in 85% of blood culture sets drawn during episodes of bacteremia, but in only 30% of the cultures thought to be contaminated (p less than 0.001). Growth of coagulase-negative staphylococci in less than 48 hours was also significantly associated with bacteremia (p less than 0.01). Antibiotic sensitivity patterns were not useful in differentiating bacteremia from contamination.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 99%