Urinary tract infection caused by <i>Gardnerella vaginalis</i> in a 2‐month‐old infant

Hanzawa, Mana; Kasai, Masashi; Sameshima, Tomohiro; Unzaki, Ai; Fukuhara, Shinichi

doi:10.1111/ped.14113

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…UTI caused by G. vaginalis in children was first described in 2020, 2 and this is the third reported case; therefore, few studies have discussed the importance of or indications for UTI treatment caused by G. vaginalis in children. A study that performed meta‐16S rRNA gene analysis on urine samples from adult UTI patients reported G. vaginalis detection in 18.8% of cases, 3 indicating that G. vaginalis ‐positive UTI cases outnumber those encountered in clinical settings.…”

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confidence: 99%

Gram staining to detect Gardnerella vaginalis urinary tract infection in a child

Shioji,

Yaginuma,

Ota

et al. 2023

Pediatrics International

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Section: Figurementioning

confidence: 99%

Gram staining to detect Gardnerella vaginalis urinary tract infection in a child

Shioji,

Yaginuma,

Ota

et al. 2023

Pediatrics International

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“…We appreciate the informative comments from Ohnishi et al 1 . regarding our manuscript 2 . We also benefited greatly from learning of the interesting case of a urinary tract infection (UTI) caused by Gardnerella vaginalis, exhibiting grade V vesicoureteral reflux (VUR).…”

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Urinary tract infection caused by Gardnerella vaginalis in a 2‐month‐old infant: Reply

Hanzawa¹,

Kasai

2020

Pediatrics International

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Dear Editor,We read with great interest the article by Hanzawa et al presenting a case of urinary tract infection (UTI) caused by Gardnerella vaginalis in a 2-month-old infant. 1 Although G. vaginalis is known to cause UTI in adults, such cases are extremely rare in infants. We also encountered a 4-month-old male infant with UTI caused by G. vaginalis and grade V vesicoureteral reflex (VUR).A 4-month-old Japanese male infant with no previous medical history was brought to our hospital with a 1-day history of fever.

…”

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confidence: 99%

Does the patient truly not have congenital anomalies of the kidney and urinary tract? Urinary tract infection caused by Gardnerella vaginalis

Ohnishi

Asato

Maeda

et al. 2020

Pediatrics International

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Dear Editor,We read with great interest the article by Hanzawa et al. presenting a case of urinary tract infection (UTI) caused by Gardnerella vaginalis in a 2-month-old infant. 1 Although G. vaginalis is known to cause UTI in adults, such cases are extremely rare in infants. We also encountered a 4-month-old male infant with UTI caused by G. vaginalis and grade V vesicoureteral reflex (VUR).A 4-month-old Japanese male infant with no previous medical history was brought to our hospital with a 1-day history of fever. He had no other apparent symptoms. On arrival at the hospital, his body temperature, heart rate, and blood pressure were 38.8 °C, 140 beats per min, and 88/52 mmHg, respectively. The physical examination revealed no notable findings, and he had a normal uncircumcized penis. His white blood cell count was 19 530/µL, and C-reactive protein level was 3.8 mg/dL. Urinalysis showed 5-9 white blood cells per high power field. Intravenous cefotaxime 150 mg/kg/day was administered. He became afebrile on day 2. Urine culture revealed G. vaginalis (1 9 10 4 CFU/mL), and blood culture was negative. On day 9, the intravenous cefotaxime was switched to oral amoxicillin 40 mg/kg/day. His voiding cystourethrography (VCUG) showed grade V VUR on the right side (Fig. 1). 16S ribosomal RNA analysis was performed, and G. vaginalis ATCC14018 was confirmed in 99% homology. No signs of sexual abuse were noted.We agree with Hanzawa et al. that G. vaginalis can cause UTI in infants even without sexual abuse. 1 However, their case is interesting, because the patient was at low risk for UTI caused by G. vaginalis for following reasons.According to the individual risk factors in the UTI guidelines by the American Academy of Pediatrics, our patient was in the high-risk group, because he was an uncircumcised nonblack infant without any other source of infection. 2 In contrast, in the case by Hanzawa et al., the only risk factor was the patient's age (below 12 months). In addition, she had upper respiratory symptoms and was diagnosed with respiratory syncytial virus (RSV) infection. Levine et al. concluded that

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Urinary tract infection caused by Gardnerella vaginalis in a 2‐month‐old infant

Cited by 5 publications

References 4 publications

Gram staining to detect Gardnerella vaginalis urinary tract infection in a child

Gram staining to detect Gardnerella vaginalis urinary tract infection in a child

Urinary tract infection caused by Gardnerella vaginalis in a 2‐month‐old infant: Reply

Does the patient truly not have congenital anomalies of the kidney and urinary tract? Urinary tract infection caused by Gardnerella vaginalis

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