Urinary TIMP‐2 and IGFBP‐7 protein levels as early predictors of acute kidney injury after cardiac surgery

Shah, Hussain Haider; Zehra, Syeda Alishah; Khatri, Mahima

doi:10.1111/jocs.16704

Cited by 1 publication

(1 citation statement)

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“…In the future, a research direction is to identify a combination of simple detection methods with low cost and high accuracy for joint biomarker detection. [72] In summary, the research on relevant biomarkers for the prediction and diagnosis of CSA-AKI, on the one hand, is to seek stability and sensitivity, and on the other hand, the specific biomarkers should continue to explore the accuracy and clinical applicability.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Mechanism and clinical role of TIMP-2 and IGFBP-7 in cardiac surgery-associated acute kidney injury: A review

Leng,

Li,

et al. 2024

Medicine

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Acute kidney injury (AKI) is a common postoperative complication, but there is still a lack of accurate biomarkers. Cardiac surgery-associated AKI is the most common cause of major-surgery-related AKI, and patients requiring renal replacement therapy have high mortality rates. Early diagnosis, intervention, and management are crucial for improving patient prognosis. However, diagnosing AKI based solely on changes in serum creatinine level and urine output is insufficient, as these changes often lag behind actual kidney damage, making early detection challenging. Biomarkers such as tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein-7 (IGFBP-7) have been found to be significant predictors of moderate-to-severe AKI when combined with urine content analysis. This article reviews the mechanism of biomarkers TIMP-2 and IGFBP-7 in AKI and provides a comprehensive overview of the clinical effects of TIMP-2 and IGFBP-7 in cardiac surgery-associated AKI, including prediction, diagnosis, and progression.

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Section: Conclusion and Prospectmentioning

confidence: 99%