Urinary thymidine dimer excretion reflects personal ultraviolet radiation exposure levels
Catharina Margrethe Lerche,
Nynne Johanne Sahl Frederiksen,
Ida Schwarz Thorsteinsson
et al.
Abstract:Exposure to ultraviolet radiation (UVR) leads to skin DNA damage, specifically in the form of cyclobutane pyrimidine dimers, with thymidine dimers being the most common. Quantifying these dimers can indicate the extent of DNA damage resulting from UVR exposure. Here, a new liquid chromatography-mass spectrometry (LC–MS) method was used to quantify thymidine dimers in the urine after a temporary increase in real-life UVR exposure. Healthy Danish volunteers (n = 27) experienced increased UVR exposure during a wi… Show more
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