Urinary tamm-horsfall protein increased after potassium citrate therapy in calcium stone formers

Fuselier, Harold A.; Ward, David M.; Lindberg, Jill S.; Allen, John M.; Husserl, Fred E.; Marcucci, Pedro A.; Cole, Francis E.; Turnipseed, Joey; Alam, Jawed; Kok, Dirk J.; Erwin, D. T.

doi:10.1016/s0090-4295(99)80112-5

Cited by 24 publications

(13 citation statements)

References 14 publications

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“…It also can reduce bone resorption and increase calcium reabsorption in kidneys. Furthermore, citrate fixes the inhibitory properties of Tamm-Horsfall protein 28 . Citrate and Tamm-Horsfall protein are related to inhibition of calcium oxalate agglomeration 29 .…”

Section: Discussionmentioning

confidence: 99%

Effect of citrus-based products on urine profile: A systematic review and meta-analysis

et al. 2017

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Background . Urolithiasis is a disease with high recurrence rate, 30-50% within 5 years. The aim of the present study was to learn the effects of citrus-based products on the urine profile in healthy persons and people with urolithiasis compared to control diet and potassium citrate. Methods. A systematic review was performed, which included interventional, prospective observational and retrospective studies, comparing citrus-based therapy with standard diet therapy, mineral water, or potassium citrate. A literature search was conducted using PUBMED, COCHRANE, and Google Scholar with “citrus or lemonade or orange or grapefruit or lime or juice” and “urolithiasis” as search terms. For statistical analysis, a fixed-effects model was conducted when p > 0.05, and random-effects model was conducted when p < 0.05. Results. In total, 135 citations were found through database searching with 10 studies found to be consistent with our selection criteria. However, only 8 studies were included in quantitative analysis, due to data availability. The present study showed a higher increased in urine pH for citrus-based products (mean difference, 0.16; 95% CI 0.01-0.32) and urinary citrate (mean difference, 124.49; 95% CI 80.24-168.74) compared with a control group. However, no differences were found in urine volume, urinary calcium, urinary oxalate, and urinary uric acid. From subgroup analysis, we found that citrus-based products consistently increased urinary citrate level higher than controls in both healthy and urolithiasis populations. Furthermore, there was lower urinary calcium level among people with urolithiasis. Conclusions. Citrus-based products could increase urinary citrate level significantly higher than control. These results should encourage further research to explore citrus-based products as a urolithiasis treatment.

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Section: Discussionmentioning

confidence: 99%

Effect of citrus-based products on urine profile: A systematic review and meta-analysis

et al. 2017

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“…Citrate is known to be decreased in the urine of stone formers, and its concentration correlates with the urine's ability to inhibit crystal agglomeration [26,48,51]. It does not seem to act directly on the crystals, but indirectly, by regulating the function of such proteins as THP [28,37]. THP and NC from stone formers are known to express functional changes [9,[36][37][38].…”

Section: Regulation Of Particle Size In the Nephronmentioning

confidence: 99%

“…Finally all these changes favor THP self-aggregation [38], and crystal agglomeration will therefore be less inhibited [26,38,50]. Alkali treatment will have the reverse effects [28,51,63]. It decreases calcium phosphate nucleation in the LH, owing to an increased citrate excretion, prevents dissolution after the LH, and thus reduces the rate of calcium oxalate formation.…”

Section: Effects Of Therapy and Diet On Nephron Conditionsmentioning

confidence: 99%

“…It decreases calcium phosphate nucleation in the LH, owing to an increased citrate excretion, prevents dissolution after the LH, and thus reduces the rate of calcium oxalate formation. Finally, it makes conditions more favorable for THP to inhibit crystal agglomeration [26,28,38,51]. On the negative side may be that calcium phosphate is allowed to grow further in size after the ALH, because of the increased pH.…”

Section: Effects Of Therapy and Diet On Nephron Conditionsmentioning

confidence: 99%

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Intratubular crystallization events

Kok¹

1997

World J Urol

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Can urolithiasis start as an intratubular event? Under severe hyperoxaluric conditions in animal models at least crystal formation can. Recently models have been presented that assess the chances of crystal formation under more normal conditions. These models describe changes in fluid composition as this passes through the nephron, these conditions being simulated in in vitro experiments. It appears that under naturally occurring intratubular conditions calcium-salt crystallization takes place within the time tubular fluid normally spends in the nephron. Precipitation starts with a calcium-phosphate phase under conditions found in the thin lambs. This crystalline phase then (partly) dissolves when collecting duct conditions are used, thereby inducing formation of calcium oxalates. Under these conditions the latter increase in size by way of crystal growth and agglomeration. Large particle formation and cell adhesion can eventually result in particle retention and subsequent stone formation. Viewing urolithiasis as originally an intratubular event has consequences for in vitro experiments and treatments, which are discussed in this paper.

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“…Both citrate and GAGs can chelate with Ca 2+ ions; citrate chelates with Ca 2+ to form 1 : 1 complexes, and 1 μ mol disaccharide unit of chondroitin sulfate (one of the GAGs) can complex with 0.757 μ mol Ca 2+ [25]. These chelated compounds were soluble; thus, the Ca 2+ concentration and CaOx saturation in urine decreased, and the growth of CaOx crystals was inhibited.…”

Section: Discussionmentioning

confidence: 99%

Concave Urinary Crystallines: Direct Evidence of Calcium Oxalate Crystals Dissolution by CitrateIn Vivo

Shang

Zhang

et al. 2013

Bioinorganic Chemistry and Applications

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The changes in urinary crystal properties in patients with calcium oxalate (CaOx) calculi after oral administration of potassium citrate (K3cit) were investigated via atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray powder diffractometry (XRD), and zeta potential analyzer. The AFM and SEM results showed that the surface of urinary crystals became concave, the edges and corners of crystals became blunt, the average size of urinary crystallines decreased significantly, and aggregation of urinary crystals was reduced. These changes were attributed to the significant increase in concentration of excreted citrate to 492 ± 118 mg/L after K3cit intake from 289 ± 83 mg/L before K3cit intake. After the amount of urinary citrate was increased, it complexed with Ca2+ ions on urinary crystals, which dissolved these crystals. Thus, the appearance of concave urinary crystals was a direct evidence of CaOx dissolution by citrate in vivo. The XRD results showed that the quantities and species of urinary crystals decreased after K3cit intake. The mechanism of inhibition of formation of CaOx stones by K3cit was possibly due to the complexation of Ca2+ with citrate, increase in urine pH, concentration of urinary inhibitor glycosaminoglycans (GAGs), and the absolute value of zeta potential after K3cit intake.

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Urinary tamm-horsfall protein increased after potassium citrate therapy in calcium stone formers

Cited by 24 publications

References 14 publications

Effect of citrus-based products on urine profile: A systematic review and meta-analysis

Effect of citrus-based products on urine profile: A systematic review and meta-analysis

Intratubular crystallization events

Concave Urinary Crystallines: Direct Evidence of Calcium Oxalate Crystals Dissolution by CitrateIn Vivo

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